Large Artery Stiffening With Weight Gain in Humans: Role of Visceral Fat Accumulation

We tested the hypothesis that weight gain would increase arterial stiffness in healthy nonobese adults. To address this, we overfed 14 nonobese men (age23±1 years) ≈1000 kcal/d for 6 to 8 weeks until a 5-kg weight gain was achieved. Carotid diameters (high-resolution ultrasound) and pressures (appla...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2008-06, Vol.51 (6), p.1519-1524
Hauptverfasser: Orr, Jeb S, Gentile, Christopher L, Davy, Brenda M, Davy, Kevin P
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1524
container_issue 6
container_start_page 1519
container_title Hypertension (Dallas, Tex. 1979)
container_volume 51
creator Orr, Jeb S
Gentile, Christopher L
Davy, Brenda M
Davy, Kevin P
description We tested the hypothesis that weight gain would increase arterial stiffness in healthy nonobese adults. To address this, we overfed 14 nonobese men (age23±1 years) ≈1000 kcal/d for 6 to 8 weeks until a 5-kg weight gain was achieved. Carotid diameters (high-resolution ultrasound) and pressures (applanation tonometry), body composition (dual energy x-ray absorptiometry), and abdominal fat distribution (computed tomography) were measured at baseline and following 4 weeks of weight stability at each individual’s elevated body weight. Overfeeding increased body weight 5.1±0.1 kg and body fat 3.4±0.4 kg (both P
doi_str_mv 10.1161/HYPERTENSIONAHA.108.112946
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70769571</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70769571</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3770-356f6e01b930463cb422f14e8df05dd1f2b09b44b673a3af7f98494045476b2c3</originalsourceid><addsrcrecordid>eNpdkF1rHCEUhqW0JNskf6FIob2b1I8zOuZuCJtsYElKPtsrcWZ119aZSXSGkH8fwy4pVJSD-rxHeRD6SskxpYL-WPz-Ob--nV_eXFxd1ov6mJIqXzAF4gOa0ZJBAaXgH9GMUAWFovTXPvqc0h9CKADIPbRPKyir3GqG7pYmri2u42jjC74ZvXO29_0aP_hxgx-sX29GfG58j_NcTJ3p0wm-HoLFg8P3PrU2moDPzIjrtp26KZjRD_0h-uRMSPZoVw_Q3dn89nRRLK_OL07rZdFyKUnBS-GEJbRRnIDgbQOMOQq2WjlSrlbUsYaoBqARkhtunHSqAgUESpCiYS0_QN-3fR_j8DTZNOru7UshmN4OU9KSSKFKSTN4sgXbOKQUrdOP0XcmvmhK9JtU_Z_UfF7prdQc_rJ7ZWo6u_oX3VnMwLcdYFJrgoumb3165xjhilPKMwdb7nkI2Xf6G6ZnG_XGmjBuNMkDmKgKRkhFRN4VeeXwK4tMj9w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70769571</pqid></control><display><type>article</type><title>Large Artery Stiffening With Weight Gain in Humans: Role of Visceral Fat Accumulation</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Complete</source><creator>Orr, Jeb S ; Gentile, Christopher L ; Davy, Brenda M ; Davy, Kevin P</creator><creatorcontrib>Orr, Jeb S ; Gentile, Christopher L ; Davy, Brenda M ; Davy, Kevin P</creatorcontrib><description>We tested the hypothesis that weight gain would increase arterial stiffness in healthy nonobese adults. To address this, we overfed 14 nonobese men (age23±1 years) ≈1000 kcal/d for 6 to 8 weeks until a 5-kg weight gain was achieved. Carotid diameters (high-resolution ultrasound) and pressures (applanation tonometry), body composition (dual energy x-ray absorptiometry), and abdominal fat distribution (computed tomography) were measured at baseline and following 4 weeks of weight stability at each individual’s elevated body weight. Overfeeding increased body weight 5.1±0.1 kg and body fat 3.4±0.4 kg (both P&lt;0.001) in 45±7 days. Total abdominal fat increased 46±7 cm with weight gain due to increases in both subcutaneous (30±6 cm) and visceral fat (15±4 cm; all P&lt;0.01). As hypothesized, weight gain increased arterial stiffness 13±6% and decreased arterial compliance 21±4% (both P&lt;0.05). Furthermore, those individuals above the median increase in abdominal visceral fat demonstrated a significantly greater increase in arterial stiffness (0.97±0.29 versus 0.06±0.36 U; P&lt;0.05) compared with those below the median. Consistent with these observations, the only correlates of the changes in arterial stiffness with weight gain were the increases in total abdominal fat (r=0.794), abdominal visceral fat (r=0.651), and waist circumference (r=0.470; all P&lt;0.05). Taken together, these findings suggest that modest weight gain is associated with increases arterial stiffness in nonobese men. The degree of large artery stiffening with weight gain seems to be determined, in part, by the amount of abdominal visceral fat gain. Importantly, this relation is independent of the amount of total body fat gained.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/HYPERTENSIONAHA.108.112946</identifier><identifier>PMID: 18458161</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Adult ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - physiology ; Body Composition ; Cardiology. Vascular system ; Carotid Arteries - diagnostic imaging ; Carotid Arteries - physiopathology ; Compliance ; Eating - physiology ; Experimental diseases ; Humans ; Hypertension - diagnostic imaging ; Hypertension - pathology ; Hypertension - physiopathology ; Intra-Abdominal Fat - pathology ; Intra-Abdominal Fat - physiopathology ; Male ; Manometry ; Medical sciences ; Obesity - pathology ; Obesity - physiopathology ; Ultrasonography ; Weight Gain - physiology</subject><ispartof>Hypertension (Dallas, Tex. 1979), 2008-06, Vol.51 (6), p.1519-1524</ispartof><rights>2008 American Heart Association, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3770-356f6e01b930463cb422f14e8df05dd1f2b09b44b673a3af7f98494045476b2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=20393113$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18458161$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Orr, Jeb S</creatorcontrib><creatorcontrib>Gentile, Christopher L</creatorcontrib><creatorcontrib>Davy, Brenda M</creatorcontrib><creatorcontrib>Davy, Kevin P</creatorcontrib><title>Large Artery Stiffening With Weight Gain in Humans: Role of Visceral Fat Accumulation</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>We tested the hypothesis that weight gain would increase arterial stiffness in healthy nonobese adults. To address this, we overfed 14 nonobese men (age23±1 years) ≈1000 kcal/d for 6 to 8 weeks until a 5-kg weight gain was achieved. Carotid diameters (high-resolution ultrasound) and pressures (applanation tonometry), body composition (dual energy x-ray absorptiometry), and abdominal fat distribution (computed tomography) were measured at baseline and following 4 weeks of weight stability at each individual’s elevated body weight. Overfeeding increased body weight 5.1±0.1 kg and body fat 3.4±0.4 kg (both P&lt;0.001) in 45±7 days. Total abdominal fat increased 46±7 cm with weight gain due to increases in both subcutaneous (30±6 cm) and visceral fat (15±4 cm; all P&lt;0.01). As hypothesized, weight gain increased arterial stiffness 13±6% and decreased arterial compliance 21±4% (both P&lt;0.05). Furthermore, those individuals above the median increase in abdominal visceral fat demonstrated a significantly greater increase in arterial stiffness (0.97±0.29 versus 0.06±0.36 U; P&lt;0.05) compared with those below the median. Consistent with these observations, the only correlates of the changes in arterial stiffness with weight gain were the increases in total abdominal fat (r=0.794), abdominal visceral fat (r=0.651), and waist circumference (r=0.470; all P&lt;0.05). Taken together, these findings suggest that modest weight gain is associated with increases arterial stiffness in nonobese men. The degree of large artery stiffening with weight gain seems to be determined, in part, by the amount of abdominal visceral fat gain. Importantly, this relation is independent of the amount of total body fat gained.</description><subject>Adult</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - physiology</subject><subject>Body Composition</subject><subject>Cardiology. Vascular system</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>Carotid Arteries - physiopathology</subject><subject>Compliance</subject><subject>Eating - physiology</subject><subject>Experimental diseases</subject><subject>Humans</subject><subject>Hypertension - diagnostic imaging</subject><subject>Hypertension - pathology</subject><subject>Hypertension - physiopathology</subject><subject>Intra-Abdominal Fat - pathology</subject><subject>Intra-Abdominal Fat - physiopathology</subject><subject>Male</subject><subject>Manometry</subject><subject>Medical sciences</subject><subject>Obesity - pathology</subject><subject>Obesity - physiopathology</subject><subject>Ultrasonography</subject><subject>Weight Gain - physiology</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkF1rHCEUhqW0JNskf6FIob2b1I8zOuZuCJtsYElKPtsrcWZ119aZSXSGkH8fwy4pVJSD-rxHeRD6SskxpYL-WPz-Ob--nV_eXFxd1ov6mJIqXzAF4gOa0ZJBAaXgH9GMUAWFovTXPvqc0h9CKADIPbRPKyir3GqG7pYmri2u42jjC74ZvXO29_0aP_hxgx-sX29GfG58j_NcTJ3p0wm-HoLFg8P3PrU2moDPzIjrtp26KZjRD_0h-uRMSPZoVw_Q3dn89nRRLK_OL07rZdFyKUnBS-GEJbRRnIDgbQOMOQq2WjlSrlbUsYaoBqARkhtunHSqAgUESpCiYS0_QN-3fR_j8DTZNOru7UshmN4OU9KSSKFKSTN4sgXbOKQUrdOP0XcmvmhK9JtU_Z_UfF7prdQc_rJ7ZWo6u_oX3VnMwLcdYFJrgoumb3165xjhilPKMwdb7nkI2Xf6G6ZnG_XGmjBuNMkDmKgKRkhFRN4VeeXwK4tMj9w</recordid><startdate>200806</startdate><enddate>200806</enddate><creator>Orr, Jeb S</creator><creator>Gentile, Christopher L</creator><creator>Davy, Brenda M</creator><creator>Davy, Kevin P</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200806</creationdate><title>Large Artery Stiffening With Weight Gain in Humans: Role of Visceral Fat Accumulation</title><author>Orr, Jeb S ; Gentile, Christopher L ; Davy, Brenda M ; Davy, Kevin P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3770-356f6e01b930463cb422f14e8df05dd1f2b09b44b673a3af7f98494045476b2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - physiology</topic><topic>Body Composition</topic><topic>Cardiology. Vascular system</topic><topic>Carotid Arteries - diagnostic imaging</topic><topic>Carotid Arteries - physiopathology</topic><topic>Compliance</topic><topic>Eating - physiology</topic><topic>Experimental diseases</topic><topic>Humans</topic><topic>Hypertension - diagnostic imaging</topic><topic>Hypertension - pathology</topic><topic>Hypertension - physiopathology</topic><topic>Intra-Abdominal Fat - pathology</topic><topic>Intra-Abdominal Fat - physiopathology</topic><topic>Male</topic><topic>Manometry</topic><topic>Medical sciences</topic><topic>Obesity - pathology</topic><topic>Obesity - physiopathology</topic><topic>Ultrasonography</topic><topic>Weight Gain - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Orr, Jeb S</creatorcontrib><creatorcontrib>Gentile, Christopher L</creatorcontrib><creatorcontrib>Davy, Brenda M</creatorcontrib><creatorcontrib>Davy, Kevin P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Orr, Jeb S</au><au>Gentile, Christopher L</au><au>Davy, Brenda M</au><au>Davy, Kevin P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Large Artery Stiffening With Weight Gain in Humans: Role of Visceral Fat Accumulation</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>2008-06</date><risdate>2008</risdate><volume>51</volume><issue>6</issue><spage>1519</spage><epage>1524</epage><pages>1519-1524</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>We tested the hypothesis that weight gain would increase arterial stiffness in healthy nonobese adults. To address this, we overfed 14 nonobese men (age23±1 years) ≈1000 kcal/d for 6 to 8 weeks until a 5-kg weight gain was achieved. Carotid diameters (high-resolution ultrasound) and pressures (applanation tonometry), body composition (dual energy x-ray absorptiometry), and abdominal fat distribution (computed tomography) were measured at baseline and following 4 weeks of weight stability at each individual’s elevated body weight. Overfeeding increased body weight 5.1±0.1 kg and body fat 3.4±0.4 kg (both P&lt;0.001) in 45±7 days. Total abdominal fat increased 46±7 cm with weight gain due to increases in both subcutaneous (30±6 cm) and visceral fat (15±4 cm; all P&lt;0.01). As hypothesized, weight gain increased arterial stiffness 13±6% and decreased arterial compliance 21±4% (both P&lt;0.05). Furthermore, those individuals above the median increase in abdominal visceral fat demonstrated a significantly greater increase in arterial stiffness (0.97±0.29 versus 0.06±0.36 U; P&lt;0.05) compared with those below the median. Consistent with these observations, the only correlates of the changes in arterial stiffness with weight gain were the increases in total abdominal fat (r=0.794), abdominal visceral fat (r=0.651), and waist circumference (r=0.470; all P&lt;0.05). Taken together, these findings suggest that modest weight gain is associated with increases arterial stiffness in nonobese men. The degree of large artery stiffening with weight gain seems to be determined, in part, by the amount of abdominal visceral fat gain. Importantly, this relation is independent of the amount of total body fat gained.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>18458161</pmid><doi>10.1161/HYPERTENSIONAHA.108.112946</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0194-911X
ispartof Hypertension (Dallas, Tex. 1979), 2008-06, Vol.51 (6), p.1519-1524
issn 0194-911X
1524-4563
language eng
recordid cdi_proquest_miscellaneous_70769571
source MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete
subjects Adult
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure - physiology
Body Composition
Cardiology. Vascular system
Carotid Arteries - diagnostic imaging
Carotid Arteries - physiopathology
Compliance
Eating - physiology
Experimental diseases
Humans
Hypertension - diagnostic imaging
Hypertension - pathology
Hypertension - physiopathology
Intra-Abdominal Fat - pathology
Intra-Abdominal Fat - physiopathology
Male
Manometry
Medical sciences
Obesity - pathology
Obesity - physiopathology
Ultrasonography
Weight Gain - physiology
title Large Artery Stiffening With Weight Gain in Humans: Role of Visceral Fat Accumulation
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T22%3A22%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Large%20Artery%20Stiffening%20With%20Weight%20Gain%20in%20Humans:%20Role%20of%20Visceral%20Fat%20Accumulation&rft.jtitle=Hypertension%20(Dallas,%20Tex.%201979)&rft.au=Orr,%20Jeb%20S&rft.date=2008-06&rft.volume=51&rft.issue=6&rft.spage=1519&rft.epage=1524&rft.pages=1519-1524&rft.issn=0194-911X&rft.eissn=1524-4563&rft.coden=HPRTDN&rft_id=info:doi/10.1161/HYPERTENSIONAHA.108.112946&rft_dat=%3Cproquest_cross%3E70769571%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70769571&rft_id=info:pmid/18458161&rfr_iscdi=true