Large Artery Stiffening With Weight Gain in Humans: Role of Visceral Fat Accumulation
We tested the hypothesis that weight gain would increase arterial stiffness in healthy nonobese adults. To address this, we overfed 14 nonobese men (age23±1 years) ≈1000 kcal/d for 6 to 8 weeks until a 5-kg weight gain was achieved. Carotid diameters (high-resolution ultrasound) and pressures (appla...
Gespeichert in:
Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 2008-06, Vol.51 (6), p.1519-1524 |
---|---|
Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 1524 |
---|---|
container_issue | 6 |
container_start_page | 1519 |
container_title | Hypertension (Dallas, Tex. 1979) |
container_volume | 51 |
creator | Orr, Jeb S Gentile, Christopher L Davy, Brenda M Davy, Kevin P |
description | We tested the hypothesis that weight gain would increase arterial stiffness in healthy nonobese adults. To address this, we overfed 14 nonobese men (age23±1 years) ≈1000 kcal/d for 6 to 8 weeks until a 5-kg weight gain was achieved. Carotid diameters (high-resolution ultrasound) and pressures (applanation tonometry), body composition (dual energy x-ray absorptiometry), and abdominal fat distribution (computed tomography) were measured at baseline and following 4 weeks of weight stability at each individual’s elevated body weight. Overfeeding increased body weight 5.1±0.1 kg and body fat 3.4±0.4 kg (both P |
doi_str_mv | 10.1161/HYPERTENSIONAHA.108.112946 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70769571</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70769571</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3770-356f6e01b930463cb422f14e8df05dd1f2b09b44b673a3af7f98494045476b2c3</originalsourceid><addsrcrecordid>eNpdkF1rHCEUhqW0JNskf6FIob2b1I8zOuZuCJtsYElKPtsrcWZ119aZSXSGkH8fwy4pVJSD-rxHeRD6SskxpYL-WPz-Ob--nV_eXFxd1ov6mJIqXzAF4gOa0ZJBAaXgH9GMUAWFovTXPvqc0h9CKADIPbRPKyir3GqG7pYmri2u42jjC74ZvXO29_0aP_hxgx-sX29GfG58j_NcTJ3p0wm-HoLFg8P3PrU2moDPzIjrtp26KZjRD_0h-uRMSPZoVw_Q3dn89nRRLK_OL07rZdFyKUnBS-GEJbRRnIDgbQOMOQq2WjlSrlbUsYaoBqARkhtunHSqAgUESpCiYS0_QN-3fR_j8DTZNOru7UshmN4OU9KSSKFKSTN4sgXbOKQUrdOP0XcmvmhK9JtU_Z_UfF7prdQc_rJ7ZWo6u_oX3VnMwLcdYFJrgoumb3165xjhilPKMwdb7nkI2Xf6G6ZnG_XGmjBuNMkDmKgKRkhFRN4VeeXwK4tMj9w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70769571</pqid></control><display><type>article</type><title>Large Artery Stiffening With Weight Gain in Humans: Role of Visceral Fat Accumulation</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Complete</source><creator>Orr, Jeb S ; Gentile, Christopher L ; Davy, Brenda M ; Davy, Kevin P</creator><creatorcontrib>Orr, Jeb S ; Gentile, Christopher L ; Davy, Brenda M ; Davy, Kevin P</creatorcontrib><description>We tested the hypothesis that weight gain would increase arterial stiffness in healthy nonobese adults. To address this, we overfed 14 nonobese men (age23±1 years) ≈1000 kcal/d for 6 to 8 weeks until a 5-kg weight gain was achieved. Carotid diameters (high-resolution ultrasound) and pressures (applanation tonometry), body composition (dual energy x-ray absorptiometry), and abdominal fat distribution (computed tomography) were measured at baseline and following 4 weeks of weight stability at each individual’s elevated body weight. Overfeeding increased body weight 5.1±0.1 kg and body fat 3.4±0.4 kg (both P<0.001) in 45±7 days. Total abdominal fat increased 46±7 cm with weight gain due to increases in both subcutaneous (30±6 cm) and visceral fat (15±4 cm; all P<0.01). As hypothesized, weight gain increased arterial stiffness 13±6% and decreased arterial compliance 21±4% (both P<0.05). Furthermore, those individuals above the median increase in abdominal visceral fat demonstrated a significantly greater increase in arterial stiffness (0.97±0.29 versus 0.06±0.36 U; P<0.05) compared with those below the median. Consistent with these observations, the only correlates of the changes in arterial stiffness with weight gain were the increases in total abdominal fat (r=0.794), abdominal visceral fat (r=0.651), and waist circumference (r=0.470; all P<0.05). Taken together, these findings suggest that modest weight gain is associated with increases arterial stiffness in nonobese men. The degree of large artery stiffening with weight gain seems to be determined, in part, by the amount of abdominal visceral fat gain. Importantly, this relation is independent of the amount of total body fat gained.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/HYPERTENSIONAHA.108.112946</identifier><identifier>PMID: 18458161</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Adult ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - physiology ; Body Composition ; Cardiology. Vascular system ; Carotid Arteries - diagnostic imaging ; Carotid Arteries - physiopathology ; Compliance ; Eating - physiology ; Experimental diseases ; Humans ; Hypertension - diagnostic imaging ; Hypertension - pathology ; Hypertension - physiopathology ; Intra-Abdominal Fat - pathology ; Intra-Abdominal Fat - physiopathology ; Male ; Manometry ; Medical sciences ; Obesity - pathology ; Obesity - physiopathology ; Ultrasonography ; Weight Gain - physiology</subject><ispartof>Hypertension (Dallas, Tex. 1979), 2008-06, Vol.51 (6), p.1519-1524</ispartof><rights>2008 American Heart Association, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3770-356f6e01b930463cb422f14e8df05dd1f2b09b44b673a3af7f98494045476b2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20393113$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18458161$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Orr, Jeb S</creatorcontrib><creatorcontrib>Gentile, Christopher L</creatorcontrib><creatorcontrib>Davy, Brenda M</creatorcontrib><creatorcontrib>Davy, Kevin P</creatorcontrib><title>Large Artery Stiffening With Weight Gain in Humans: Role of Visceral Fat Accumulation</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>We tested the hypothesis that weight gain would increase arterial stiffness in healthy nonobese adults. To address this, we overfed 14 nonobese men (age23±1 years) ≈1000 kcal/d for 6 to 8 weeks until a 5-kg weight gain was achieved. Carotid diameters (high-resolution ultrasound) and pressures (applanation tonometry), body composition (dual energy x-ray absorptiometry), and abdominal fat distribution (computed tomography) were measured at baseline and following 4 weeks of weight stability at each individual’s elevated body weight. Overfeeding increased body weight 5.1±0.1 kg and body fat 3.4±0.4 kg (both P<0.001) in 45±7 days. Total abdominal fat increased 46±7 cm with weight gain due to increases in both subcutaneous (30±6 cm) and visceral fat (15±4 cm; all P<0.01). As hypothesized, weight gain increased arterial stiffness 13±6% and decreased arterial compliance 21±4% (both P<0.05). Furthermore, those individuals above the median increase in abdominal visceral fat demonstrated a significantly greater increase in arterial stiffness (0.97±0.29 versus 0.06±0.36 U; P<0.05) compared with those below the median. Consistent with these observations, the only correlates of the changes in arterial stiffness with weight gain were the increases in total abdominal fat (r=0.794), abdominal visceral fat (r=0.651), and waist circumference (r=0.470; all P<0.05). Taken together, these findings suggest that modest weight gain is associated with increases arterial stiffness in nonobese men. The degree of large artery stiffening with weight gain seems to be determined, in part, by the amount of abdominal visceral fat gain. Importantly, this relation is independent of the amount of total body fat gained.</description><subject>Adult</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - physiology</subject><subject>Body Composition</subject><subject>Cardiology. Vascular system</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>Carotid Arteries - physiopathology</subject><subject>Compliance</subject><subject>Eating - physiology</subject><subject>Experimental diseases</subject><subject>Humans</subject><subject>Hypertension - diagnostic imaging</subject><subject>Hypertension - pathology</subject><subject>Hypertension - physiopathology</subject><subject>Intra-Abdominal Fat - pathology</subject><subject>Intra-Abdominal Fat - physiopathology</subject><subject>Male</subject><subject>Manometry</subject><subject>Medical sciences</subject><subject>Obesity - pathology</subject><subject>Obesity - physiopathology</subject><subject>Ultrasonography</subject><subject>Weight Gain - physiology</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkF1rHCEUhqW0JNskf6FIob2b1I8zOuZuCJtsYElKPtsrcWZ119aZSXSGkH8fwy4pVJSD-rxHeRD6SskxpYL-WPz-Ob--nV_eXFxd1ov6mJIqXzAF4gOa0ZJBAaXgH9GMUAWFovTXPvqc0h9CKADIPbRPKyir3GqG7pYmri2u42jjC74ZvXO29_0aP_hxgx-sX29GfG58j_NcTJ3p0wm-HoLFg8P3PrU2moDPzIjrtp26KZjRD_0h-uRMSPZoVw_Q3dn89nRRLK_OL07rZdFyKUnBS-GEJbRRnIDgbQOMOQq2WjlSrlbUsYaoBqARkhtunHSqAgUESpCiYS0_QN-3fR_j8DTZNOru7UshmN4OU9KSSKFKSTN4sgXbOKQUrdOP0XcmvmhK9JtU_Z_UfF7prdQc_rJ7ZWo6u_oX3VnMwLcdYFJrgoumb3165xjhilPKMwdb7nkI2Xf6G6ZnG_XGmjBuNMkDmKgKRkhFRN4VeeXwK4tMj9w</recordid><startdate>200806</startdate><enddate>200806</enddate><creator>Orr, Jeb S</creator><creator>Gentile, Christopher L</creator><creator>Davy, Brenda M</creator><creator>Davy, Kevin P</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200806</creationdate><title>Large Artery Stiffening With Weight Gain in Humans: Role of Visceral Fat Accumulation</title><author>Orr, Jeb S ; Gentile, Christopher L ; Davy, Brenda M ; Davy, Kevin P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3770-356f6e01b930463cb422f14e8df05dd1f2b09b44b673a3af7f98494045476b2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - physiology</topic><topic>Body Composition</topic><topic>Cardiology. Vascular system</topic><topic>Carotid Arteries - diagnostic imaging</topic><topic>Carotid Arteries - physiopathology</topic><topic>Compliance</topic><topic>Eating - physiology</topic><topic>Experimental diseases</topic><topic>Humans</topic><topic>Hypertension - diagnostic imaging</topic><topic>Hypertension - pathology</topic><topic>Hypertension - physiopathology</topic><topic>Intra-Abdominal Fat - pathology</topic><topic>Intra-Abdominal Fat - physiopathology</topic><topic>Male</topic><topic>Manometry</topic><topic>Medical sciences</topic><topic>Obesity - pathology</topic><topic>Obesity - physiopathology</topic><topic>Ultrasonography</topic><topic>Weight Gain - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Orr, Jeb S</creatorcontrib><creatorcontrib>Gentile, Christopher L</creatorcontrib><creatorcontrib>Davy, Brenda M</creatorcontrib><creatorcontrib>Davy, Kevin P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Orr, Jeb S</au><au>Gentile, Christopher L</au><au>Davy, Brenda M</au><au>Davy, Kevin P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Large Artery Stiffening With Weight Gain in Humans: Role of Visceral Fat Accumulation</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>2008-06</date><risdate>2008</risdate><volume>51</volume><issue>6</issue><spage>1519</spage><epage>1524</epage><pages>1519-1524</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>We tested the hypothesis that weight gain would increase arterial stiffness in healthy nonobese adults. To address this, we overfed 14 nonobese men (age23±1 years) ≈1000 kcal/d for 6 to 8 weeks until a 5-kg weight gain was achieved. Carotid diameters (high-resolution ultrasound) and pressures (applanation tonometry), body composition (dual energy x-ray absorptiometry), and abdominal fat distribution (computed tomography) were measured at baseline and following 4 weeks of weight stability at each individual’s elevated body weight. Overfeeding increased body weight 5.1±0.1 kg and body fat 3.4±0.4 kg (both P<0.001) in 45±7 days. Total abdominal fat increased 46±7 cm with weight gain due to increases in both subcutaneous (30±6 cm) and visceral fat (15±4 cm; all P<0.01). As hypothesized, weight gain increased arterial stiffness 13±6% and decreased arterial compliance 21±4% (both P<0.05). Furthermore, those individuals above the median increase in abdominal visceral fat demonstrated a significantly greater increase in arterial stiffness (0.97±0.29 versus 0.06±0.36 U; P<0.05) compared with those below the median. Consistent with these observations, the only correlates of the changes in arterial stiffness with weight gain were the increases in total abdominal fat (r=0.794), abdominal visceral fat (r=0.651), and waist circumference (r=0.470; all P<0.05). Taken together, these findings suggest that modest weight gain is associated with increases arterial stiffness in nonobese men. The degree of large artery stiffening with weight gain seems to be determined, in part, by the amount of abdominal visceral fat gain. Importantly, this relation is independent of the amount of total body fat gained.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>18458161</pmid><doi>10.1161/HYPERTENSIONAHA.108.112946</doi><tpages>6</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0194-911X |
ispartof | Hypertension (Dallas, Tex. 1979), 2008-06, Vol.51 (6), p.1519-1524 |
issn | 0194-911X 1524-4563 |
language | eng |
recordid | cdi_proquest_miscellaneous_70769571 |
source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
subjects | Adult Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - physiology Body Composition Cardiology. Vascular system Carotid Arteries - diagnostic imaging Carotid Arteries - physiopathology Compliance Eating - physiology Experimental diseases Humans Hypertension - diagnostic imaging Hypertension - pathology Hypertension - physiopathology Intra-Abdominal Fat - pathology Intra-Abdominal Fat - physiopathology Male Manometry Medical sciences Obesity - pathology Obesity - physiopathology Ultrasonography Weight Gain - physiology |
title | Large Artery Stiffening With Weight Gain in Humans: Role of Visceral Fat Accumulation |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T22%3A22%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Large%20Artery%20Stiffening%20With%20Weight%20Gain%20in%20Humans:%20Role%20of%20Visceral%20Fat%20Accumulation&rft.jtitle=Hypertension%20(Dallas,%20Tex.%201979)&rft.au=Orr,%20Jeb%20S&rft.date=2008-06&rft.volume=51&rft.issue=6&rft.spage=1519&rft.epage=1524&rft.pages=1519-1524&rft.issn=0194-911X&rft.eissn=1524-4563&rft.coden=HPRTDN&rft_id=info:doi/10.1161/HYPERTENSIONAHA.108.112946&rft_dat=%3Cproquest_cross%3E70769571%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70769571&rft_id=info:pmid/18458161&rfr_iscdi=true |