Design, Synthesis, and Antifungal Activities of Novel 1H-Triazole Derivatives Based on the Structure of the Active Site of Fungal Lanosterol 14α-Demethylase (CYP51)

A series of fluconazole (1) analogues, compounds 3a–k, were prepared as potential antifungal agents. They were designed by computational docking experiments to the active site of the cytochrome P450 14α‐sterol demethylase (CYP51), whose crystal structure is known. Preliminary biological tests showed...

Ausführliche Beschreibung