CD59 Efficiently Protects Human NT2-N Neurons Against Complement-mediated Damage

The complement regulatory protein CD59 controls cell survival by the inhibition of C5b-9 formation on the cell membrane. Loss of CD59 increases the susceptibility of cells to complement-mediated damage and lysis. Deposition of IgM can induce complement activation with subsequent cell death. We have...

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Veröffentlicht in:	Scandinavian journal of immunology 2007-08, Vol.66 (2-3), p.345-351
Hauptverfasser:	Pedersen, E.D, Aass, H.C.D, Rootwelt, T, Fung, M, Lambris, J.D, Mollnes, T.E
Format:	Artikel
Sprache:	eng
Schlagworte:	CD59 Antigens - physiology Cell Death - immunology Cell Line, Tumor Cell-Free System Complement Activation - immunology Complement Membrane Attack Complex - metabolism Complement Membrane Attack Complex - physiology Humans Immunoglobulin M - physiology Neurons - immunology Neurons - metabolism Neurons - pathology
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