Haloperidol regulates the phosphorylation level of the MEK-ERK-p90RSK signal pathway via protein phosphatase 2A in the rat frontal cortex

Haloperidol, a classical antipsychotic drug, affects the extracellular signal-regulated kinase (ERK) pathway in the brain. However, findings are inconsistent and the mechanism by which haloperidol regulates ERK is poorly understood. Therefore, we examined the ERK pathway and the related protein phos...

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Veröffentlicht in:	The international journal of neuropsychopharmacology 2008-06, Vol.11 (4), p.509-517
Hauptverfasser:	Kim, Se Hyun, Seo, Myoung Suk, Jeon, Won Je, Yu, Hyun-Sook, Park, Hong Geun, Jung, Gyung-Ah, Lee, Hee Young, Kang, Ung Gu, Kim, Yong Sik
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antipsychotic Agents - pharmacology Blotting, Western Dose-Response Relationship, Drug Extracellular Signal-Regulated MAP Kinases - genetics Extracellular Signal-Regulated MAP Kinases - physiology Haloperidol - pharmacology Immunoprecipitation Kinases Male Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - physiology Phosphoprotein Phosphatases - metabolism Phosphorylation - drug effects Prefrontal Cortex - drug effects Prefrontal Cortex - enzymology Prefrontal Cortex - physiology Protein Phosphatase 2 - physiology Proteins Proto-Oncogene Proteins c-raf - genetics Proto-Oncogene Proteins c-raf - physiology Psychotropic drugs raf Kinases - physiology Rats Rats, Sprague-Dawley Ribosomal Protein S6 Kinases, 90-kDa - genetics Ribosomal Protein S6 Kinases, 90-kDa - physiology Rodents Signal Transduction - drug effects
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