Quercetin induced tissue‐type plasminogen activator expression is mediated through Sp1 and p38 mitogen‐activated protein kinase in human endothelial cells

Background: Wine polyphenol quercetin upregulates tissue‐type plasminogen activator (t‐PA) transcription in cultured human umbilical cord vein endothelial cells (HUVECs). However, the regulatory elements and signaling pathways involved in this regulation are unknown. Objectives: We aimed to localize...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2008-06, Vol.6 (6), p.976-985
Hauptverfasser:	PAN, W., CHANG, M. J., BOOYSE, F. M., GRENETT, H. E., BRADLEY, K. M., WOLKOWICZ, P. E., SHANG, Q., TABENGWA, E. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - pharmacology Cells, Cultured Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Enzyme Inhibitors - pharmacology Flavonoids - chemistry Gene Expression Regulation Humans Models, Biological p38 MAPK p38 Mitogen-Activated Protein Kinases - metabolism Phenols - chemistry Polyphenols Promoter Regions, Genetic Protein Binding quercetin Quercetin - pharmacology response element Sp1 Sp1 Transcription Factor - metabolism Thrombosis - metabolism tissue plasminogen activator Up-Regulation
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