Scintimammography enhances negative predictive value of non-invasive pre-operative assessment of breast lesions
Aims: The aim of this study was to develop a criterion with a high negative predictive value for the evaluation of breast lesions. We aimed to determine the value of combining three non-invasive tests, mammography (MM), ultrasonography (USS) and 99mTc-methoxyisobutylisonitrite (99mTc-MIBI) scintimam...
Gespeichert in:
Veröffentlicht in: | European journal of surgical oncology 2000-12, Vol.26 (8), p.738-741 |
---|---|
Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 741 |
---|---|
container_issue | 8 |
container_start_page | 738 |
container_title | European journal of surgical oncology |
container_volume | 26 |
creator | Mirzaei, S. Zajicek, S.M. Knoll, P. Lipp, C. Lipp, R.W. Salzer, H. Umek, H. Kohn, H. |
description | Aims: The aim of this study was to develop a criterion with a high negative predictive value for the evaluation of breast lesions. We aimed to determine the value of combining three non-invasive tests, mammography (MM), ultrasonography (USS) and 99mTc-methoxyisobutylisonitrite (99mTc-MIBI) scintimammography (scinti-MM). Methods: We included 94 consecutive patients with suspected lesions detected by mammography or on physical examination. MM, USS and scinti-MM were performed no more than 4 weeks prior to excisional biopsy in all patients. We then compared the biopsy results with a score calculated for each patient, derived from the results of the three tests, which we termed «mamma malignancy index» (MMI). Results: Each of the three exams yielded a score ranging from 0 to 2, with 0 representing an almost certainly benign lesion, 1 an indeterminate finding and 2 a likely malignant lesion, and hence giving a total score ranging from 0 to 6. The biopsy results showed that the lesions in 64 patients were benign. Forty-nine (77%) of these patients had received an MMI score of 0 or 1. The negative predictive value for malignancy in patients with a score less than 2 was 100%.Conclusions: Since the smallest detected lesion was 9 mm in diameter, we conclude that MMI may be a highly useful diagnostic tool in the delineation of breast lesions ≥1 cm which should not be routinely referred for biopsy but may be followed non-invasively. Although fine needle aspiration has limitations, we would recommend it as a less invasive method to evaluate suspected lesions smaller than 1 cm. |
doi_str_mv | 10.1053/ejso.2000.0995 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70768596</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0748798300909958</els_id><sourcerecordid>70768596</sourcerecordid><originalsourceid>FETCH-LOGICAL-c368t-6bf53be088cb48d4144d71839db271814ed2ef2e73f02732912139941242bc6b3</originalsourceid><addsrcrecordid>eNp10b9r3DAUwHFRGprLtWvHYihk80U_bEsaS2iTQCBDk1nI8vNFwZZcPd9B_vvKPZNOmaThoyfxFSFfGd0xWosreMG445TSHdW6_kA2rBa85KyWH8mGykqVUitxTi4QX7LSQupP5JwxqmQj5IbE386H2Y92HOM-2en5tYDwbIMDLALs7eyPUEwJOu_-bY92OEAR-yLEUPpwtLiCMk6QTtwiAuIIYV5gm8DiXAyAPgb8TM56OyB8Wdctefr18_H6trx_uLm7_nFfOtGouWzavhYtUKVcW6muYlXVSaaE7lqeV1ZBx6HnIEVPuRRcM86E1hXjFW9d04otuTzNnVL8cwCczejRwTDYAPGARlLZqFo3Ge5O0KWImKA3U8o50qth1CyJzZLYLInNkjgf-LZOPrQjdP_52jSD7yuw6OzQp1zT45tT-YPkcq86KcgVjh6SQechd-98AjebLvr3XvAXEFiZQQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70768596</pqid></control><display><type>article</type><title>Scintimammography enhances negative predictive value of non-invasive pre-operative assessment of breast lesions</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Mirzaei, S. ; Zajicek, S.M. ; Knoll, P. ; Lipp, C. ; Lipp, R.W. ; Salzer, H. ; Umek, H. ; Kohn, H.</creator><creatorcontrib>Mirzaei, S. ; Zajicek, S.M. ; Knoll, P. ; Lipp, C. ; Lipp, R.W. ; Salzer, H. ; Umek, H. ; Kohn, H.</creatorcontrib><description>Aims: The aim of this study was to develop a criterion with a high negative predictive value for the evaluation of breast lesions. We aimed to determine the value of combining three non-invasive tests, mammography (MM), ultrasonography (USS) and 99mTc-methoxyisobutylisonitrite (99mTc-MIBI) scintimammography (scinti-MM). Methods: We included 94 consecutive patients with suspected lesions detected by mammography or on physical examination. MM, USS and scinti-MM were performed no more than 4 weeks prior to excisional biopsy in all patients. We then compared the biopsy results with a score calculated for each patient, derived from the results of the three tests, which we termed «mamma malignancy index» (MMI). Results: Each of the three exams yielded a score ranging from 0 to 2, with 0 representing an almost certainly benign lesion, 1 an indeterminate finding and 2 a likely malignant lesion, and hence giving a total score ranging from 0 to 6. The biopsy results showed that the lesions in 64 patients were benign. Forty-nine (77%) of these patients had received an MMI score of 0 or 1. The negative predictive value for malignancy in patients with a score less than 2 was 100%.Conclusions: Since the smallest detected lesion was 9 mm in diameter, we conclude that MMI may be a highly useful diagnostic tool in the delineation of breast lesions ≥1 cm which should not be routinely referred for biopsy but may be followed non-invasively. Although fine needle aspiration has limitations, we would recommend it as a less invasive method to evaluate suspected lesions smaller than 1 cm.</description><identifier>ISSN: 0748-7983</identifier><identifier>EISSN: 1532-2157</identifier><identifier>DOI: 10.1053/ejso.2000.0995</identifier><identifier>PMID: 11087637</identifier><identifier>CODEN: EJSOE7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; biopsy ; Biopsy, Needle ; Breast - pathology ; breast cancer ; Breast Diseases - diagnosis ; Breast Diseases - diagnostic imaging ; Breast Neoplasms - diagnosis ; Diagnosis, Differential ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Mammary gland diseases ; Mammography ; Medical sciences ; Middle Aged ; Predictive Value of Tests ; Radionuclide Imaging - methods ; scintimammography ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the genital tract and mammary gland ; Technetium ; Tumors ; Ultrasonography, Mammary</subject><ispartof>European journal of surgical oncology, 2000-12, Vol.26 (8), p.738-741</ispartof><rights>2000 Harcourt Publishers Ltd</rights><rights>2001 INIST-CNRS</rights><rights>Copyright 2000 Harcourt Publishers Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-6bf53be088cb48d4144d71839db271814ed2ef2e73f02732912139941242bc6b3</citedby><cites>FETCH-LOGICAL-c368t-6bf53be088cb48d4144d71839db271814ed2ef2e73f02732912139941242bc6b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1053/ejso.2000.0995$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,23930,23931,25140,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=853276$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11087637$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mirzaei, S.</creatorcontrib><creatorcontrib>Zajicek, S.M.</creatorcontrib><creatorcontrib>Knoll, P.</creatorcontrib><creatorcontrib>Lipp, C.</creatorcontrib><creatorcontrib>Lipp, R.W.</creatorcontrib><creatorcontrib>Salzer, H.</creatorcontrib><creatorcontrib>Umek, H.</creatorcontrib><creatorcontrib>Kohn, H.</creatorcontrib><title>Scintimammography enhances negative predictive value of non-invasive pre-operative assessment of breast lesions</title><title>European journal of surgical oncology</title><addtitle>Eur J Surg Oncol</addtitle><description>Aims: The aim of this study was to develop a criterion with a high negative predictive value for the evaluation of breast lesions. We aimed to determine the value of combining three non-invasive tests, mammography (MM), ultrasonography (USS) and 99mTc-methoxyisobutylisonitrite (99mTc-MIBI) scintimammography (scinti-MM). Methods: We included 94 consecutive patients with suspected lesions detected by mammography or on physical examination. MM, USS and scinti-MM were performed no more than 4 weeks prior to excisional biopsy in all patients. We then compared the biopsy results with a score calculated for each patient, derived from the results of the three tests, which we termed «mamma malignancy index» (MMI). Results: Each of the three exams yielded a score ranging from 0 to 2, with 0 representing an almost certainly benign lesion, 1 an indeterminate finding and 2 a likely malignant lesion, and hence giving a total score ranging from 0 to 6. The biopsy results showed that the lesions in 64 patients were benign. Forty-nine (77%) of these patients had received an MMI score of 0 or 1. The negative predictive value for malignancy in patients with a score less than 2 was 100%.Conclusions: Since the smallest detected lesion was 9 mm in diameter, we conclude that MMI may be a highly useful diagnostic tool in the delineation of breast lesions ≥1 cm which should not be routinely referred for biopsy but may be followed non-invasively. Although fine needle aspiration has limitations, we would recommend it as a less invasive method to evaluate suspected lesions smaller than 1 cm.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>biopsy</subject><subject>Biopsy, Needle</subject><subject>Breast - pathology</subject><subject>breast cancer</subject><subject>Breast Diseases - diagnosis</subject><subject>Breast Diseases - diagnostic imaging</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Mammography</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>Radionuclide Imaging - methods</subject><subject>scintimammography</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the genital tract and mammary gland</subject><subject>Technetium</subject><subject>Tumors</subject><subject>Ultrasonography, Mammary</subject><issn>0748-7983</issn><issn>1532-2157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10b9r3DAUwHFRGprLtWvHYihk80U_bEsaS2iTQCBDk1nI8vNFwZZcPd9B_vvKPZNOmaThoyfxFSFfGd0xWosreMG445TSHdW6_kA2rBa85KyWH8mGykqVUitxTi4QX7LSQupP5JwxqmQj5IbE386H2Y92HOM-2en5tYDwbIMDLALs7eyPUEwJOu_-bY92OEAR-yLEUPpwtLiCMk6QTtwiAuIIYV5gm8DiXAyAPgb8TM56OyB8Wdctefr18_H6trx_uLm7_nFfOtGouWzavhYtUKVcW6muYlXVSaaE7lqeV1ZBx6HnIEVPuRRcM86E1hXjFW9d04otuTzNnVL8cwCczejRwTDYAPGARlLZqFo3Ge5O0KWImKA3U8o50qth1CyJzZLYLInNkjgf-LZOPrQjdP_52jSD7yuw6OzQp1zT45tT-YPkcq86KcgVjh6SQechd-98AjebLvr3XvAXEFiZQQ</recordid><startdate>20001201</startdate><enddate>20001201</enddate><creator>Mirzaei, S.</creator><creator>Zajicek, S.M.</creator><creator>Knoll, P.</creator><creator>Lipp, C.</creator><creator>Lipp, R.W.</creator><creator>Salzer, H.</creator><creator>Umek, H.</creator><creator>Kohn, H.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20001201</creationdate><title>Scintimammography enhances negative predictive value of non-invasive pre-operative assessment of breast lesions</title><author>Mirzaei, S. ; Zajicek, S.M. ; Knoll, P. ; Lipp, C. ; Lipp, R.W. ; Salzer, H. ; Umek, H. ; Kohn, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-6bf53be088cb48d4144d71839db271814ed2ef2e73f02732912139941242bc6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>biopsy</topic><topic>Biopsy, Needle</topic><topic>Breast - pathology</topic><topic>breast cancer</topic><topic>Breast Diseases - diagnosis</topic><topic>Breast Diseases - diagnostic imaging</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>Mammography</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>Radionuclide Imaging - methods</topic><topic>scintimammography</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the genital tract and mammary gland</topic><topic>Technetium</topic><topic>Tumors</topic><topic>Ultrasonography, Mammary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mirzaei, S.</creatorcontrib><creatorcontrib>Zajicek, S.M.</creatorcontrib><creatorcontrib>Knoll, P.</creatorcontrib><creatorcontrib>Lipp, C.</creatorcontrib><creatorcontrib>Lipp, R.W.</creatorcontrib><creatorcontrib>Salzer, H.</creatorcontrib><creatorcontrib>Umek, H.</creatorcontrib><creatorcontrib>Kohn, H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mirzaei, S.</au><au>Zajicek, S.M.</au><au>Knoll, P.</au><au>Lipp, C.</au><au>Lipp, R.W.</au><au>Salzer, H.</au><au>Umek, H.</au><au>Kohn, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Scintimammography enhances negative predictive value of non-invasive pre-operative assessment of breast lesions</atitle><jtitle>European journal of surgical oncology</jtitle><addtitle>Eur J Surg Oncol</addtitle><date>2000-12-01</date><risdate>2000</risdate><volume>26</volume><issue>8</issue><spage>738</spage><epage>741</epage><pages>738-741</pages><issn>0748-7983</issn><eissn>1532-2157</eissn><coden>EJSOE7</coden><abstract>Aims: The aim of this study was to develop a criterion with a high negative predictive value for the evaluation of breast lesions. We aimed to determine the value of combining three non-invasive tests, mammography (MM), ultrasonography (USS) and 99mTc-methoxyisobutylisonitrite (99mTc-MIBI) scintimammography (scinti-MM). Methods: We included 94 consecutive patients with suspected lesions detected by mammography or on physical examination. MM, USS and scinti-MM were performed no more than 4 weeks prior to excisional biopsy in all patients. We then compared the biopsy results with a score calculated for each patient, derived from the results of the three tests, which we termed «mamma malignancy index» (MMI). Results: Each of the three exams yielded a score ranging from 0 to 2, with 0 representing an almost certainly benign lesion, 1 an indeterminate finding and 2 a likely malignant lesion, and hence giving a total score ranging from 0 to 6. The biopsy results showed that the lesions in 64 patients were benign. Forty-nine (77%) of these patients had received an MMI score of 0 or 1. The negative predictive value for malignancy in patients with a score less than 2 was 100%.Conclusions: Since the smallest detected lesion was 9 mm in diameter, we conclude that MMI may be a highly useful diagnostic tool in the delineation of breast lesions ≥1 cm which should not be routinely referred for biopsy but may be followed non-invasively. Although fine needle aspiration has limitations, we would recommend it as a less invasive method to evaluate suspected lesions smaller than 1 cm.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>11087637</pmid><doi>10.1053/ejso.2000.0995</doi><tpages>4</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0748-7983 |
ispartof | European journal of surgical oncology, 2000-12, Vol.26 (8), p.738-741 |
issn | 0748-7983 1532-2157 |
language | eng |
recordid | cdi_proquest_miscellaneous_70768596 |
source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
subjects | Adult Aged Aged, 80 and over Biological and medical sciences biopsy Biopsy, Needle Breast - pathology breast cancer Breast Diseases - diagnosis Breast Diseases - diagnostic imaging Breast Neoplasms - diagnosis Diagnosis, Differential Female Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Mammography Medical sciences Middle Aged Predictive Value of Tests Radionuclide Imaging - methods scintimammography Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the genital tract and mammary gland Technetium Tumors Ultrasonography, Mammary |
title | Scintimammography enhances negative predictive value of non-invasive pre-operative assessment of breast lesions |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T17%3A58%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Scintimammography%20enhances%20negative%20predictive%20value%20of%20non-invasive%20pre-operative%20assessment%20of%20breast%20lesions&rft.jtitle=European%20journal%20of%20surgical%20oncology&rft.au=Mirzaei,%20S.&rft.date=2000-12-01&rft.volume=26&rft.issue=8&rft.spage=738&rft.epage=741&rft.pages=738-741&rft.issn=0748-7983&rft.eissn=1532-2157&rft.coden=EJSOE7&rft_id=info:doi/10.1053/ejso.2000.0995&rft_dat=%3Cproquest_cross%3E70768596%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70768596&rft_id=info:pmid/11087637&rft_els_id=S0748798300909958&rfr_iscdi=true |