MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation

MicroRNAs (miRNAs) are small RNAs that function as posttranscriptional regulators of gene expression. miRNAs affect a variety of signaling pathways, and impaired miRNA regulation may contribute to the development of cancer and other diseases. Here we show that miRNA miR-10a interacts with the 5'...

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Veröffentlicht in:	Molecular cell 2008-05, Vol.30 (4), p.460-471
Hauptverfasser:	Ørom, Ulf Andersson, Nielsen, Finn Cilius, Lund, Anders H
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions Amino Acids - metabolism Animals Base Sequence Binding Sites Cell Transformation, Neoplastic HeLa Cells Humans Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Molecular Sequence Data NIH 3T3 Cells Protein Biosynthesis Rats Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Ribosomal Proteins - genetics Ribosomal Proteins - metabolism
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