Prevention of suckling improves postpartum reproductive responses to hormone treatments in Pelibuey ewes
To determine the effects of suckling on postpartum (pp) reproductive efficiency in Pelibuey ewes, two experiments were performed. In Experiment 1, 112 ewes were randomly assigned to one of two groups at parturition: Without restriction of suckling (WRS) 24 h day −1 for 60 days ( n = 56), and Weaned...
Gespeichert in:
| Veröffentlicht in: | Animal reproduction science 2008-08, Vol.107 (1), p.85-93 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 93 |
|---|---|
| container_issue | 1 |
| container_start_page | 85 |
| container_title | Animal reproduction science |
| container_volume | 107 |
| creator | Ronquillo, Julio César Camacho Martínez, Arturo Pró Pérez, Carlos Miguel Becerril Sandoval, Benjamín Figueroa Martin, Graeme B. Valencia, Javier Gallegos Sánchez, Jaime |
| description | To determine the effects of suckling on postpartum (pp) reproductive efficiency in Pelibuey ewes, two experiments were performed. In Experiment 1, 112 ewes were randomly assigned to one of two groups at parturition: Without restriction of suckling (WRS) 24
h
day
−1 for 60 days (
n
=
56), and Weaned Ewes (WE), weaned at 40 days pp (
n
=
56). On Day 30 pp, all ewes were given Prostaglandin (PGF2α) and one of four treatments (
n
=
14): T1, intravaginal progestagen (FGA; 40
mg) for 12 days from day 30 pp
+
equine chorionic gonadotropin (eCG; 300
UI) until 2 days before removing FGA; T2, FGA was applied for 12 days; T3, a second application of PGF2α was given on day 40 pp
+
eCG on the same day; T4, a second injection of PGF2α was applied on day 40 pp only. In all the analyzed characteristics, the best results were obtained in WE. Within the WE group, the best treatment (
P
<
0.05) was T1 with 85.7% of the ewes in oestrus, 71.4% pregnant and a prolificacy of 1.9. Within the WRS group the best results were observed in T1. In both groups, the lowest results (
P
<
0.05) were obtained in T4. In Experiment 2, 75 ewes were randomly assigned to one of three groups (
n
=
25) immediately after parturition: Group 1, Without restriction of suckling (WRS, as in Experiment 1); Group 2, with restriction of suckling (RS; suckling for 30
min
day
−1); Group 3, Early Weaning (EW: at 7 days pp). All ewes were given PGF2α at 30 days pp and the same hormonal treatment, FGA for 12 days
+
PGF2α and eCG 2 days before removing FGA. No differences were observed (
P
>
0.05) between RS and EW for the presentation of oestrus (96% vs. 92%), pregnancy (72% vs. 76%) or prolificacy (1.9 vs. 1.9), although group WRS did not perform (
P
<
0.05) as well as groups RS and EW for any measure of performance. In conclusion, the combination of hormonal treatment (FGA plus eCG) with weaning at 7 or 40 days pp, or restricted suckling, improves postpartum reproductive efficiency in Pelibuey ewes, demonstrating the inhibitory role of suckling on postpartum reproduction in this breed. |
| doi_str_mv | 10.1016/j.anireprosci.2007.06.021 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70766766</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378432007002424</els_id><sourcerecordid>70766766</sourcerecordid><originalsourceid>FETCH-LOGICAL-c399t-241c3e132d1ef6a87b8ea9ae306fcca971c0a3f75c27ccdb4c5a1b7f3ee13bab3</originalsourceid><addsrcrecordid>eNqNkE1r3DAQhkVpaLZp_0KrXnqzM5I21vpYlvQDAgmkOQtZHifa2pIryVvy7zvbXWiPBcEgeN55h4exDwJqAaK53NU2-IRzitn5WgLoGpoapHjBVmKjVSWlki_ZCpTeVGsl4Zy9znkHBDZN-4qdi8NsQK_Y013CPYbiY-Bx4HlxP0YfHrmfaPseM59jLrNNZZn4n8Z-ccXvkT55jiETUSJ_immKAXlJaMtE6zL3gd_h6LsFnzn-wvyGnQ12zPj2NC_Yw-fr79uv1c3tl2_bTzeVU21bKrkWTqFQshc4NHajuw3a1qKCZnDOtlo4sGrQV05q5_pu7a6s6PSgkEKd7dQF-3jcS7f-XDAXM_nscBxtwLhkow8O6BHYHkFHGnPCwczJTzY9GwHmoNnszD-azUGzgcaQZsq-O5Us3YT93-TJKwHvj8Bgo7GPyWfzcC9BKIAWQAAQsT0SSDL2HpOhEgwOe6p0xfTR_8chvwHUcaJs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70766766</pqid></control><display><type>article</type><title>Prevention of suckling improves postpartum reproductive responses to hormone treatments in Pelibuey ewes</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Ronquillo, Julio César Camacho ; Martínez, Arturo Pró ; Pérez, Carlos Miguel Becerril ; Sandoval, Benjamín Figueroa ; Martin, Graeme B. ; Valencia, Javier ; Gallegos Sánchez, Jaime</creator><creatorcontrib>Ronquillo, Julio César Camacho ; Martínez, Arturo Pró ; Pérez, Carlos Miguel Becerril ; Sandoval, Benjamín Figueroa ; Martin, Graeme B. ; Valencia, Javier ; Gallegos Sánchez, Jaime</creatorcontrib><description>To determine the effects of suckling on postpartum (pp) reproductive efficiency in Pelibuey ewes, two experiments were performed. In Experiment 1, 112 ewes were randomly assigned to one of two groups at parturition: Without restriction of suckling (WRS) 24
h
day
−1 for 60 days (
n
=
56), and Weaned Ewes (WE), weaned at 40 days pp (
n
=
56). On Day 30 pp, all ewes were given Prostaglandin (PGF2α) and one of four treatments (
n
=
14): T1, intravaginal progestagen (FGA; 40
mg) for 12 days from day 30 pp
+
equine chorionic gonadotropin (eCG; 300
UI) until 2 days before removing FGA; T2, FGA was applied for 12 days; T3, a second application of PGF2α was given on day 40 pp
+
eCG on the same day; T4, a second injection of PGF2α was applied on day 40 pp only. In all the analyzed characteristics, the best results were obtained in WE. Within the WE group, the best treatment (
P
<
0.05) was T1 with 85.7% of the ewes in oestrus, 71.4% pregnant and a prolificacy of 1.9. Within the WRS group the best results were observed in T1. In both groups, the lowest results (
P
<
0.05) were obtained in T4. In Experiment 2, 75 ewes were randomly assigned to one of three groups (
n
=
25) immediately after parturition: Group 1, Without restriction of suckling (WRS, as in Experiment 1); Group 2, with restriction of suckling (RS; suckling for 30
min
day
−1); Group 3, Early Weaning (EW: at 7 days pp). All ewes were given PGF2α at 30 days pp and the same hormonal treatment, FGA for 12 days
+
PGF2α and eCG 2 days before removing FGA. No differences were observed (
P
>
0.05) between RS and EW for the presentation of oestrus (96% vs. 92%), pregnancy (72% vs. 76%) or prolificacy (1.9 vs. 1.9), although group WRS did not perform (
P
<
0.05) as well as groups RS and EW for any measure of performance. In conclusion, the combination of hormonal treatment (FGA plus eCG) with weaning at 7 or 40 days pp, or restricted suckling, improves postpartum reproductive efficiency in Pelibuey ewes, demonstrating the inhibitory role of suckling on postpartum reproduction in this breed.</description><identifier>ISSN: 0378-4320</identifier><identifier>EISSN: 1873-2232</identifier><identifier>DOI: 10.1016/j.anireprosci.2007.06.021</identifier><identifier>PMID: 17669607</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Buserelin - administration & dosage ; Buserelin - pharmacology ; Drug Administration Schedule ; Early Weaning ; Estrus Synchronization - drug effects ; ewes ; Female ; Fertility ; Fertility Agents, Female - administration & dosage ; Fertility Agents, Female - pharmacology ; hormone supplements ; Induction of oestrous ; Lactation - physiology ; Pelibuey (sheep breed) ; postpartum interval ; Postpartum Period ; Pregnancy ; Pregnancy Rate ; progestational hormones ; Prolificacy ; prostaglandins ; Prostaglandins F, Synthetic - administration & dosage ; Prostaglandins F, Synthetic - pharmacology ; reproductive efficiency ; Sheep - physiology ; sheep breeds ; suckling ; Synchronization ; Weaning</subject><ispartof>Animal reproduction science, 2008-08, Vol.107 (1), p.85-93</ispartof><rights>2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-241c3e132d1ef6a87b8ea9ae306fcca971c0a3f75c27ccdb4c5a1b7f3ee13bab3</citedby><cites>FETCH-LOGICAL-c399t-241c3e132d1ef6a87b8ea9ae306fcca971c0a3f75c27ccdb4c5a1b7f3ee13bab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378432007002424$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17669607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ronquillo, Julio César Camacho</creatorcontrib><creatorcontrib>Martínez, Arturo Pró</creatorcontrib><creatorcontrib>Pérez, Carlos Miguel Becerril</creatorcontrib><creatorcontrib>Sandoval, Benjamín Figueroa</creatorcontrib><creatorcontrib>Martin, Graeme B.</creatorcontrib><creatorcontrib>Valencia, Javier</creatorcontrib><creatorcontrib>Gallegos Sánchez, Jaime</creatorcontrib><title>Prevention of suckling improves postpartum reproductive responses to hormone treatments in Pelibuey ewes</title><title>Animal reproduction science</title><addtitle>Anim Reprod Sci</addtitle><description>To determine the effects of suckling on postpartum (pp) reproductive efficiency in Pelibuey ewes, two experiments were performed. In Experiment 1, 112 ewes were randomly assigned to one of two groups at parturition: Without restriction of suckling (WRS) 24
h
day
−1 for 60 days (
n
=
56), and Weaned Ewes (WE), weaned at 40 days pp (
n
=
56). On Day 30 pp, all ewes were given Prostaglandin (PGF2α) and one of four treatments (
n
=
14): T1, intravaginal progestagen (FGA; 40
mg) for 12 days from day 30 pp
+
equine chorionic gonadotropin (eCG; 300
UI) until 2 days before removing FGA; T2, FGA was applied for 12 days; T3, a second application of PGF2α was given on day 40 pp
+
eCG on the same day; T4, a second injection of PGF2α was applied on day 40 pp only. In all the analyzed characteristics, the best results were obtained in WE. Within the WE group, the best treatment (
P
<
0.05) was T1 with 85.7% of the ewes in oestrus, 71.4% pregnant and a prolificacy of 1.9. Within the WRS group the best results were observed in T1. In both groups, the lowest results (
P
<
0.05) were obtained in T4. In Experiment 2, 75 ewes were randomly assigned to one of three groups (
n
=
25) immediately after parturition: Group 1, Without restriction of suckling (WRS, as in Experiment 1); Group 2, with restriction of suckling (RS; suckling for 30
min
day
−1); Group 3, Early Weaning (EW: at 7 days pp). All ewes were given PGF2α at 30 days pp and the same hormonal treatment, FGA for 12 days
+
PGF2α and eCG 2 days before removing FGA. No differences were observed (
P
>
0.05) between RS and EW for the presentation of oestrus (96% vs. 92%), pregnancy (72% vs. 76%) or prolificacy (1.9 vs. 1.9), although group WRS did not perform (
P
<
0.05) as well as groups RS and EW for any measure of performance. In conclusion, the combination of hormonal treatment (FGA plus eCG) with weaning at 7 or 40 days pp, or restricted suckling, improves postpartum reproductive efficiency in Pelibuey ewes, demonstrating the inhibitory role of suckling on postpartum reproduction in this breed.</description><subject>Animals</subject><subject>Buserelin - administration & dosage</subject><subject>Buserelin - pharmacology</subject><subject>Drug Administration Schedule</subject><subject>Early Weaning</subject><subject>Estrus Synchronization - drug effects</subject><subject>ewes</subject><subject>Female</subject><subject>Fertility</subject><subject>Fertility Agents, Female - administration & dosage</subject><subject>Fertility Agents, Female - pharmacology</subject><subject>hormone supplements</subject><subject>Induction of oestrous</subject><subject>Lactation - physiology</subject><subject>Pelibuey (sheep breed)</subject><subject>postpartum interval</subject><subject>Postpartum Period</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>progestational hormones</subject><subject>Prolificacy</subject><subject>prostaglandins</subject><subject>Prostaglandins F, Synthetic - administration & dosage</subject><subject>Prostaglandins F, Synthetic - pharmacology</subject><subject>reproductive efficiency</subject><subject>Sheep - physiology</subject><subject>sheep breeds</subject><subject>suckling</subject><subject>Synchronization</subject><subject>Weaning</subject><issn>0378-4320</issn><issn>1873-2232</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1r3DAQhkVpaLZp_0KrXnqzM5I21vpYlvQDAgmkOQtZHifa2pIryVvy7zvbXWiPBcEgeN55h4exDwJqAaK53NU2-IRzitn5WgLoGpoapHjBVmKjVSWlki_ZCpTeVGsl4Zy9znkHBDZN-4qdi8NsQK_Y013CPYbiY-Bx4HlxP0YfHrmfaPseM59jLrNNZZn4n8Z-ccXvkT55jiETUSJ_immKAXlJaMtE6zL3gd_h6LsFnzn-wvyGnQ12zPj2NC_Yw-fr79uv1c3tl2_bTzeVU21bKrkWTqFQshc4NHajuw3a1qKCZnDOtlo4sGrQV05q5_pu7a6s6PSgkEKd7dQF-3jcS7f-XDAXM_nscBxtwLhkow8O6BHYHkFHGnPCwczJTzY9GwHmoNnszD-azUGzgcaQZsq-O5Us3YT93-TJKwHvj8Bgo7GPyWfzcC9BKIAWQAAQsT0SSDL2HpOhEgwOe6p0xfTR_8chvwHUcaJs</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Ronquillo, Julio César Camacho</creator><creator>Martínez, Arturo Pró</creator><creator>Pérez, Carlos Miguel Becerril</creator><creator>Sandoval, Benjamín Figueroa</creator><creator>Martin, Graeme B.</creator><creator>Valencia, Javier</creator><creator>Gallegos Sánchez, Jaime</creator><general>Elsevier B.V</general><general>[Amsterdam]: Elsevier Science</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080801</creationdate><title>Prevention of suckling improves postpartum reproductive responses to hormone treatments in Pelibuey ewes</title><author>Ronquillo, Julio César Camacho ; Martínez, Arturo Pró ; Pérez, Carlos Miguel Becerril ; Sandoval, Benjamín Figueroa ; Martin, Graeme B. ; Valencia, Javier ; Gallegos Sánchez, Jaime</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-241c3e132d1ef6a87b8ea9ae306fcca971c0a3f75c27ccdb4c5a1b7f3ee13bab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Buserelin - administration & dosage</topic><topic>Buserelin - pharmacology</topic><topic>Drug Administration Schedule</topic><topic>Early Weaning</topic><topic>Estrus Synchronization - drug effects</topic><topic>ewes</topic><topic>Female</topic><topic>Fertility</topic><topic>Fertility Agents, Female - administration & dosage</topic><topic>Fertility Agents, Female - pharmacology</topic><topic>hormone supplements</topic><topic>Induction of oestrous</topic><topic>Lactation - physiology</topic><topic>Pelibuey (sheep breed)</topic><topic>postpartum interval</topic><topic>Postpartum Period</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>progestational hormones</topic><topic>Prolificacy</topic><topic>prostaglandins</topic><topic>Prostaglandins F, Synthetic - administration & dosage</topic><topic>Prostaglandins F, Synthetic - pharmacology</topic><topic>reproductive efficiency</topic><topic>Sheep - physiology</topic><topic>sheep breeds</topic><topic>suckling</topic><topic>Synchronization</topic><topic>Weaning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ronquillo, Julio César Camacho</creatorcontrib><creatorcontrib>Martínez, Arturo Pró</creatorcontrib><creatorcontrib>Pérez, Carlos Miguel Becerril</creatorcontrib><creatorcontrib>Sandoval, Benjamín Figueroa</creatorcontrib><creatorcontrib>Martin, Graeme B.</creatorcontrib><creatorcontrib>Valencia, Javier</creatorcontrib><creatorcontrib>Gallegos Sánchez, Jaime</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Animal reproduction science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ronquillo, Julio César Camacho</au><au>Martínez, Arturo Pró</au><au>Pérez, Carlos Miguel Becerril</au><au>Sandoval, Benjamín Figueroa</au><au>Martin, Graeme B.</au><au>Valencia, Javier</au><au>Gallegos Sánchez, Jaime</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevention of suckling improves postpartum reproductive responses to hormone treatments in Pelibuey ewes</atitle><jtitle>Animal reproduction science</jtitle><addtitle>Anim Reprod Sci</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>107</volume><issue>1</issue><spage>85</spage><epage>93</epage><pages>85-93</pages><issn>0378-4320</issn><eissn>1873-2232</eissn><abstract>To determine the effects of suckling on postpartum (pp) reproductive efficiency in Pelibuey ewes, two experiments were performed. In Experiment 1, 112 ewes were randomly assigned to one of two groups at parturition: Without restriction of suckling (WRS) 24
h
day
−1 for 60 days (
n
=
56), and Weaned Ewes (WE), weaned at 40 days pp (
n
=
56). On Day 30 pp, all ewes were given Prostaglandin (PGF2α) and one of four treatments (
n
=
14): T1, intravaginal progestagen (FGA; 40
mg) for 12 days from day 30 pp
+
equine chorionic gonadotropin (eCG; 300
UI) until 2 days before removing FGA; T2, FGA was applied for 12 days; T3, a second application of PGF2α was given on day 40 pp
+
eCG on the same day; T4, a second injection of PGF2α was applied on day 40 pp only. In all the analyzed characteristics, the best results were obtained in WE. Within the WE group, the best treatment (
P
<
0.05) was T1 with 85.7% of the ewes in oestrus, 71.4% pregnant and a prolificacy of 1.9. Within the WRS group the best results were observed in T1. In both groups, the lowest results (
P
<
0.05) were obtained in T4. In Experiment 2, 75 ewes were randomly assigned to one of three groups (
n
=
25) immediately after parturition: Group 1, Without restriction of suckling (WRS, as in Experiment 1); Group 2, with restriction of suckling (RS; suckling for 30
min
day
−1); Group 3, Early Weaning (EW: at 7 days pp). All ewes were given PGF2α at 30 days pp and the same hormonal treatment, FGA for 12 days
+
PGF2α and eCG 2 days before removing FGA. No differences were observed (
P
>
0.05) between RS and EW for the presentation of oestrus (96% vs. 92%), pregnancy (72% vs. 76%) or prolificacy (1.9 vs. 1.9), although group WRS did not perform (
P
<
0.05) as well as groups RS and EW for any measure of performance. In conclusion, the combination of hormonal treatment (FGA plus eCG) with weaning at 7 or 40 days pp, or restricted suckling, improves postpartum reproductive efficiency in Pelibuey ewes, demonstrating the inhibitory role of suckling on postpartum reproduction in this breed.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>17669607</pmid><doi>10.1016/j.anireprosci.2007.06.021</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-4320 |
| ispartof | Animal reproduction science, 2008-08, Vol.107 (1), p.85-93 |
| issn | 0378-4320 1873-2232 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70766766 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Buserelin - administration & dosage Buserelin - pharmacology Drug Administration Schedule Early Weaning Estrus Synchronization - drug effects ewes Female Fertility Fertility Agents, Female - administration & dosage Fertility Agents, Female - pharmacology hormone supplements Induction of oestrous Lactation - physiology Pelibuey (sheep breed) postpartum interval Postpartum Period Pregnancy Pregnancy Rate progestational hormones Prolificacy prostaglandins Prostaglandins F, Synthetic - administration & dosage Prostaglandins F, Synthetic - pharmacology reproductive efficiency Sheep - physiology sheep breeds suckling Synchronization Weaning |
| title | Prevention of suckling improves postpartum reproductive responses to hormone treatments in Pelibuey ewes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T23%3A20%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevention%20of%20suckling%20improves%20postpartum%20reproductive%20responses%20to%20hormone%20treatments%20in%20Pelibuey%20ewes&rft.jtitle=Animal%20reproduction%20science&rft.au=Ronquillo,%20Julio%20C%C3%A9sar%20Camacho&rft.date=2008-08-01&rft.volume=107&rft.issue=1&rft.spage=85&rft.epage=93&rft.pages=85-93&rft.issn=0378-4320&rft.eissn=1873-2232&rft_id=info:doi/10.1016/j.anireprosci.2007.06.021&rft_dat=%3Cproquest_cross%3E70766766%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70766766&rft_id=info:pmid/17669607&rft_els_id=S0378432007002424&rfr_iscdi=true |