Postprandial serum induces apoptosis in endothelial cells: Role of polymorphonuclear-derived myeloperoxidase and metalloproteinase-9 activity

Abstract Postprandial state is a pro-inflammatory condition associated with a transient impairment of endothelial function. Recent evidence suggests that myeloperoxidase (MPO) and matrix metalloproteinase-9 (MMP-9) are involved in the pathogenesis of inflammatory vascular diseases such as atheroscle...

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Veröffentlicht in:	Atherosclerosis 2008-06, Vol.198 (2), p.458-467
Hauptverfasser:	Spallarossa, Paolo, Garibaldi, Silvano, Barisione, Chiara, Ghigliotti, Giorgio, Altieri, Paola, Tracchi, Irene, Fabbi, Patrizia, Barsotti, Antonio, Brunelli, Claudio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Apoptosis Atherosclerosis (general aspects, experimental research) Atherosclerosis - etiology Biological and medical sciences Blood and lymphatic vessels Blood vessels and receptors Cardiology. Vascular system Cardiovascular CD146 Antigen - blood Endothelial apoptosis Endothelium, Vascular - cytology Endothelium, Vascular - physiology Fat meal Fats - administration & dosage Feeding Behavior Fundamental and applied biological sciences. Psychology Humans Male Matrix Metalloproteinase 9 - physiology Medical sciences Metalloproteinase-9 Middle Aged Myeloperoxidase Neutrophils - enzymology Oxidation-Reduction Peroxidase - physiology Polymorphonuclear cells Postprandial Period Proteins - metabolism Reactive Oxygen Species - blood Reactive Oxygen Species - metabolism Serum - chemistry Triglycerides - blood Vertebrates: cardiovascular system
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