Selective Abolishment of Pyrimidine Nucleoside Kinase Activity of Herpes Simplex Virus Type 1 Thymidine Kinase by Mutation of Alanine-167 to Tyrosine

Herpes simplex virus type 1 (HSV-1) encodes a thymidine kinase (TK) that markedly differs from mammalian nucleoside kinases in terms of substrate specificity. It recognizes both pyrimidine 2â²-deoxynucleosides and a variety of purine nucleoside analogs. Based on a computer modeling study and in an...

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Veröffentlicht in:	Molecular pharmacology 2000-12, Vol.58 (6), p.1326-1332
Hauptverfasser:	Degrève, B, Esnouf, R, De Clercq, E, Balzarini, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - genetics Alanine - metabolism Amino Acid Substitution Antiviral Agents - metabolism Antiviral Agents - pharmacology Bone Neoplasms Cell Division - drug effects Ganciclovir - metabolism Ganciclovir - pharmacology Herpesvirus 1, Human - drug effects Herpesvirus 1, Human - enzymology Herpesvirus 1, Human - genetics Humans Osteosarcoma Phosphorylation Point Mutation Purine Nucleosides - metabolism Pyrimidine Nucleosides - metabolism Thymidine Kinase - genetics Thymidine Kinase - metabolism Transduction, Genetic Tumor Cells, Cultured Tyrosine - genetics Tyrosine - metabolism
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