Relationship between seminal antioxidant enzymes and the phospholipid and fatty acid composition of spermatozoa
Abstract Sperm cell membranes are susceptible to peroxidative damage through an excess of reactive oxygen species. The objective of this study was to determine seminal plasma glutathione peroxidase (GPX) and superoxide dismutase (SOD) activity and relate these to phospholipid profiles and phospholip...
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| Veröffentlicht in: | Reproductive biomedicine online 2008, Vol.16 (5), p.649-656 |
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| creator | Tavilani, Heidar Goodarzi, Mohamad Taghi Doosti, Mahmoud Vaisi-Raygani, Asad Hassanzadeh, Taghi Salimi, Saeedeh Joshaghani, Hamid Reza |
| description | Abstract Sperm cell membranes are susceptible to peroxidative damage through an excess of reactive oxygen species. The objective of this study was to determine seminal plasma glutathione peroxidase (GPX) and superoxide dismutase (SOD) activity and relate these to phospholipid profiles and phospholipid-esterified fatty acid composition of spermatozoa. Seminal plasma GPX and SOD activity, phospholipid, phospholipid-esterified fatty acid composition and malondialdehyde (MDA) of spermatozoa were assayed in 10 normozoospermic and 25 asthenozoospermic subjects. Mean seminal GPX and SOD activity in normozoospermic men were not significantly different from asthenozoospermic men. A significant positive correlation was observed between seminal plasma GPX activity and phosphatidylcholine content ( r = +0.77, P = 0.037) and there was a significant negative correlation with lysophosphatidylcholine content ( r = −0.89, P = 0.02) in normozoospermic sperm samples. Positive correlations were found between SOD activity and polyunsaturated fatty acid composition of spermatozoa. MDA content in the spermatozoa of asthenozoospermic subjects was significantly higher than in normozoospermic males ( P < 0.05). Negative correlations were found between MDA content and seminal SOD activity and arachidonic acid content of spermatozoa from normozoospermic samples ( r = −0.5; P = 0.046, r = −0.9; P = 0.001 respectively). Seminal plasma GPX and SOD provide protection against lipid peroxidation of phospholipid and phospholipid-bound fatty acids in normozoospermic samples. |
| doi_str_mv | 10.1016/S1472-6483(10)60478-6 |
| format | Article |
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The objective of this study was to determine seminal plasma glutathione peroxidase (GPX) and superoxide dismutase (SOD) activity and relate these to phospholipid profiles and phospholipid-esterified fatty acid composition of spermatozoa. Seminal plasma GPX and SOD activity, phospholipid, phospholipid-esterified fatty acid composition and malondialdehyde (MDA) of spermatozoa were assayed in 10 normozoospermic and 25 asthenozoospermic subjects. Mean seminal GPX and SOD activity in normozoospermic men were not significantly different from asthenozoospermic men. A significant positive correlation was observed between seminal plasma GPX activity and phosphatidylcholine content ( r = +0.77, P = 0.037) and there was a significant negative correlation with lysophosphatidylcholine content ( r = −0.89, P = 0.02) in normozoospermic sperm samples. Positive correlations were found between SOD activity and polyunsaturated fatty acid composition of spermatozoa. MDA content in the spermatozoa of asthenozoospermic subjects was significantly higher than in normozoospermic males ( P < 0.05). Negative correlations were found between MDA content and seminal SOD activity and arachidonic acid content of spermatozoa from normozoospermic samples ( r = −0.5; P = 0.046, r = −0.9; P = 0.001 respectively). Seminal plasma GPX and SOD provide protection against lipid peroxidation of phospholipid and phospholipid-bound fatty acids in normozoospermic samples.</description><identifier>ISSN: 1472-6483</identifier><identifier>EISSN: 1472-6491</identifier><identifier>DOI: 10.1016/S1472-6483(10)60478-6</identifier><identifier>PMID: 18492368</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Antioxidants - metabolism ; Fatty Acids - metabolism ; glutathione peroxidase ; Glutathione Peroxidase - metabolism ; Humans ; Male ; Malondialdehyde - metabolism ; Obstetrics and Gynecology ; phospholipid ; Phospholipids - metabolism ; polyunsaturated fatty acid ; semen ; Semen - enzymology ; Spermatozoa - metabolism ; superoxide dismutase ; Superoxide Dismutase - metabolism</subject><ispartof>Reproductive biomedicine online, 2008, Vol.16 (5), p.649-656</ispartof><rights>Reproductive Healthcare Ltd, Duck End Farm, Dry Drayton, Cambridge CB23 8DB, UK</rights><rights>2008 Reproductive Healthcare Ltd, Duck End Farm, Dry Drayton, Cambridge CB23 8DB, UK</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-e206121f89e1229f2369d5c3bffdd339511223d5b617c889852ca9c86a8cd2463</citedby><cites>FETCH-LOGICAL-c418t-e206121f89e1229f2369d5c3bffdd339511223d5b617c889852ca9c86a8cd2463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1472648310604786$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18492368$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tavilani, Heidar</creatorcontrib><creatorcontrib>Goodarzi, Mohamad Taghi</creatorcontrib><creatorcontrib>Doosti, Mahmoud</creatorcontrib><creatorcontrib>Vaisi-Raygani, Asad</creatorcontrib><creatorcontrib>Hassanzadeh, Taghi</creatorcontrib><creatorcontrib>Salimi, Saeedeh</creatorcontrib><creatorcontrib>Joshaghani, Hamid Reza</creatorcontrib><title>Relationship between seminal antioxidant enzymes and the phospholipid and fatty acid composition of spermatozoa</title><title>Reproductive biomedicine online</title><addtitle>Reprod Biomed Online</addtitle><description>Abstract Sperm cell membranes are susceptible to peroxidative damage through an excess of reactive oxygen species. The objective of this study was to determine seminal plasma glutathione peroxidase (GPX) and superoxide dismutase (SOD) activity and relate these to phospholipid profiles and phospholipid-esterified fatty acid composition of spermatozoa. Seminal plasma GPX and SOD activity, phospholipid, phospholipid-esterified fatty acid composition and malondialdehyde (MDA) of spermatozoa were assayed in 10 normozoospermic and 25 asthenozoospermic subjects. Mean seminal GPX and SOD activity in normozoospermic men were not significantly different from asthenozoospermic men. A significant positive correlation was observed between seminal plasma GPX activity and phosphatidylcholine content ( r = +0.77, P = 0.037) and there was a significant negative correlation with lysophosphatidylcholine content ( r = −0.89, P = 0.02) in normozoospermic sperm samples. Positive correlations were found between SOD activity and polyunsaturated fatty acid composition of spermatozoa. MDA content in the spermatozoa of asthenozoospermic subjects was significantly higher than in normozoospermic males ( P < 0.05). Negative correlations were found between MDA content and seminal SOD activity and arachidonic acid content of spermatozoa from normozoospermic samples ( r = −0.5; P = 0.046, r = −0.9; P = 0.001 respectively). Seminal plasma GPX and SOD provide protection against lipid peroxidation of phospholipid and phospholipid-bound fatty acids in normozoospermic samples.</description><subject>Antioxidants - metabolism</subject><subject>Fatty Acids - metabolism</subject><subject>glutathione peroxidase</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Obstetrics and Gynecology</subject><subject>phospholipid</subject><subject>Phospholipids - metabolism</subject><subject>polyunsaturated fatty acid</subject><subject>semen</subject><subject>Semen - enzymology</subject><subject>Spermatozoa - metabolism</subject><subject>superoxide dismutase</subject><subject>Superoxide Dismutase - metabolism</subject><issn>1472-6483</issn><issn>1472-6491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuPFCEUhYnROOPoT9CwMroo5VFFwcaJmfhKJjHxsSY03EozVhUll1Z7fr1Ud0cTNy7IhcPhu3Ag5DFnLzjj6uVn3vaiUa2Wzzh7rljb60bdIecn2fC7f-ZanpEHiDeMcc20vE_OuG6NkEqfk_QJRldimnEbF7qB8hNgpghTnN1I3Vy3fsVQK4X5dj8BVi3QsgW6bBPWMcYlhoM4uFL21Pm69GlaEsaVS9NAcYE8uZJuk3tI7g1uRHh0qhfk69s3X67eN9cf3324en3d-Jbr0oBgigs-aANcCDPUy5rQebkZhhCkNB2vsgzdRvHea210J7wzXiunfRCtkhfk6ZG75PR9B1jsFNHDOLoZ0g5tz3rVdr2pxu5o9DkhZhjskuPk8t5yZtek7SFpu8a4Soek7drgyanBbjNB-HvqFG01XB4NUJ_5I0K26CPMHkLM4IsNKf63xat_CH6Mc_Ru_AZ7wJu0y_WT0HKLwrIjZGVwdiAo-RsMsqSM</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Tavilani, Heidar</creator><creator>Goodarzi, Mohamad Taghi</creator><creator>Doosti, Mahmoud</creator><creator>Vaisi-Raygani, Asad</creator><creator>Hassanzadeh, Taghi</creator><creator>Salimi, Saeedeh</creator><creator>Joshaghani, Hamid Reza</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Relationship between seminal antioxidant enzymes and the phospholipid and fatty acid composition of spermatozoa</title><author>Tavilani, Heidar ; Goodarzi, Mohamad Taghi ; Doosti, Mahmoud ; Vaisi-Raygani, Asad ; Hassanzadeh, Taghi ; Salimi, Saeedeh ; Joshaghani, Hamid Reza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-e206121f89e1229f2369d5c3bffdd339511223d5b617c889852ca9c86a8cd2463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Antioxidants - metabolism</topic><topic>Fatty Acids - metabolism</topic><topic>glutathione peroxidase</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Obstetrics and Gynecology</topic><topic>phospholipid</topic><topic>Phospholipids - metabolism</topic><topic>polyunsaturated fatty acid</topic><topic>semen</topic><topic>Semen - enzymology</topic><topic>Spermatozoa - metabolism</topic><topic>superoxide dismutase</topic><topic>Superoxide Dismutase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tavilani, Heidar</creatorcontrib><creatorcontrib>Goodarzi, Mohamad Taghi</creatorcontrib><creatorcontrib>Doosti, Mahmoud</creatorcontrib><creatorcontrib>Vaisi-Raygani, Asad</creatorcontrib><creatorcontrib>Hassanzadeh, Taghi</creatorcontrib><creatorcontrib>Salimi, Saeedeh</creatorcontrib><creatorcontrib>Joshaghani, Hamid Reza</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Reproductive biomedicine online</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tavilani, Heidar</au><au>Goodarzi, Mohamad Taghi</au><au>Doosti, Mahmoud</au><au>Vaisi-Raygani, Asad</au><au>Hassanzadeh, Taghi</au><au>Salimi, Saeedeh</au><au>Joshaghani, Hamid Reza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between seminal antioxidant enzymes and the phospholipid and fatty acid composition of spermatozoa</atitle><jtitle>Reproductive biomedicine online</jtitle><addtitle>Reprod Biomed Online</addtitle><date>2008</date><risdate>2008</risdate><volume>16</volume><issue>5</issue><spage>649</spage><epage>656</epage><pages>649-656</pages><issn>1472-6483</issn><eissn>1472-6491</eissn><abstract>Abstract Sperm cell membranes are susceptible to peroxidative damage through an excess of reactive oxygen species. The objective of this study was to determine seminal plasma glutathione peroxidase (GPX) and superoxide dismutase (SOD) activity and relate these to phospholipid profiles and phospholipid-esterified fatty acid composition of spermatozoa. Seminal plasma GPX and SOD activity, phospholipid, phospholipid-esterified fatty acid composition and malondialdehyde (MDA) of spermatozoa were assayed in 10 normozoospermic and 25 asthenozoospermic subjects. Mean seminal GPX and SOD activity in normozoospermic men were not significantly different from asthenozoospermic men. A significant positive correlation was observed between seminal plasma GPX activity and phosphatidylcholine content ( r = +0.77, P = 0.037) and there was a significant negative correlation with lysophosphatidylcholine content ( r = −0.89, P = 0.02) in normozoospermic sperm samples. Positive correlations were found between SOD activity and polyunsaturated fatty acid composition of spermatozoa. MDA content in the spermatozoa of asthenozoospermic subjects was significantly higher than in normozoospermic males ( P < 0.05). Negative correlations were found between MDA content and seminal SOD activity and arachidonic acid content of spermatozoa from normozoospermic samples ( r = −0.5; P = 0.046, r = −0.9; P = 0.001 respectively). Seminal plasma GPX and SOD provide protection against lipid peroxidation of phospholipid and phospholipid-bound fatty acids in normozoospermic samples.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>18492368</pmid><doi>10.1016/S1472-6483(10)60478-6</doi><tpages>8</tpages></addata></record> |
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| subjects | Antioxidants - metabolism Fatty Acids - metabolism glutathione peroxidase Glutathione Peroxidase - metabolism Humans Male Malondialdehyde - metabolism Obstetrics and Gynecology phospholipid Phospholipids - metabolism polyunsaturated fatty acid semen Semen - enzymology Spermatozoa - metabolism superoxide dismutase Superoxide Dismutase - metabolism |
| title | Relationship between seminal antioxidant enzymes and the phospholipid and fatty acid composition of spermatozoa |
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