Protein synthesis inhibition before or after stress exposure results in divergent endocrine and BDNF responses disassociated from behavioral responses
This study aimed to assess the effects of anisomycin, a protein synthesis inhibitor, on behavioral responses, brain‐derived neurotrophic factor (BDNF) and TrkB mRNA levels, and circulating corticosterone in rats—when administered before or after initial exposure to a predator scent stress stimulus....
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| Veröffentlicht in: | Depression and anxiety 2008-05, Vol.25 (5), p.E24-E34 |
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| container_title | Depression and anxiety |
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| creator | Kozlovsky, Nitsan Kaplan, Zeev Zohar, Joseph Matar, Michael A. Shimon, Hady Cohen, Hagit |
| description | This study aimed to assess the effects of anisomycin, a protein synthesis inhibitor, on behavioral responses, brain‐derived neurotrophic factor (BDNF) and TrkB mRNA levels, and circulating corticosterone in rats—when administered before or after initial exposure to a predator scent stress stimulus. Magnitude of changes in prevalence of anxiety‐like behaviors on the elevated plus‐maze and exaggerated startle reaction as well as corticosterone levels and mRNA BDNF and TrkB were compared in rats exposed to predator stress, microinjected with anisomycin before or after stress exposure. Administration of anisomycin before or after stress exposure reduced anxiety‐like behavior in the elevated plus‐maze and reduced the mean startle amplitude 7 days postexposure. Although the behavioral responses were similar when anisomycin was microinjected before or after stress exposure, the levels of mRNAs for BDNF and TrkB, which play a role in modulation of synaptic plasticity and the consolidation process, showed varying responses. Depression and Anxiety 0:1–11, 2007. © 2007 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/da.20366 |
| format | Article |
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Magnitude of changes in prevalence of anxiety‐like behaviors on the elevated plus‐maze and exaggerated startle reaction as well as corticosterone levels and mRNA BDNF and TrkB were compared in rats exposed to predator stress, microinjected with anisomycin before or after stress exposure. Administration of anisomycin before or after stress exposure reduced anxiety‐like behavior in the elevated plus‐maze and reduced the mean startle amplitude 7 days postexposure. Although the behavioral responses were similar when anisomycin was microinjected before or after stress exposure, the levels of mRNAs for BDNF and TrkB, which play a role in modulation of synaptic plasticity and the consolidation process, showed varying responses. Depression and Anxiety 0:1–11, 2007. © 2007 Wiley‐Liss, Inc.</description><identifier>ISSN: 1091-4269</identifier><identifier>EISSN: 1520-6394</identifier><identifier>DOI: 10.1002/da.20366</identifier><identifier>PMID: 17828750</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; anisomycin ; Anisomycin - pharmacology ; anxiety-like behavior ; Behavior, Animal - drug effects ; brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - genetics ; corticosterone ; Corticosterone - blood ; Fear - physiology ; Frontal Lobe - drug effects ; Frontal Lobe - pathology ; Hippocampus - drug effects ; Hippocampus - pathology ; Male ; Maze Learning - drug effects ; Microinjections ; Neuronal Plasticity - drug effects ; protein synthesis inhibitor ; Protein Synthesis Inhibitors - pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptor, trkB - genetics ; Reflex, Startle - drug effects ; RNA, Messenger - genetics ; stress ; Stress, Psychological - complications ; TrkB</subject><ispartof>Depression and anxiety, 2008-05, Vol.25 (5), p.E24-E34</ispartof><rights>2007 Wiley‐Liss, Inc.</rights><rights>(c) 2007 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3346-57651e2624147755c83d237dbd8fa96c166dbb8082a3563b407985b3894d437c3</citedby><cites>FETCH-LOGICAL-c3346-57651e2624147755c83d237dbd8fa96c166dbb8082a3563b407985b3894d437c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fda.20366$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fda.20366$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17828750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kozlovsky, Nitsan</creatorcontrib><creatorcontrib>Kaplan, Zeev</creatorcontrib><creatorcontrib>Zohar, Joseph</creatorcontrib><creatorcontrib>Matar, Michael A.</creatorcontrib><creatorcontrib>Shimon, Hady</creatorcontrib><creatorcontrib>Cohen, Hagit</creatorcontrib><title>Protein synthesis inhibition before or after stress exposure results in divergent endocrine and BDNF responses disassociated from behavioral responses</title><title>Depression and anxiety</title><addtitle>Depress. Anxiety</addtitle><description>This study aimed to assess the effects of anisomycin, a protein synthesis inhibitor, on behavioral responses, brain‐derived neurotrophic factor (BDNF) and TrkB mRNA levels, and circulating corticosterone in rats—when administered before or after initial exposure to a predator scent stress stimulus. Magnitude of changes in prevalence of anxiety‐like behaviors on the elevated plus‐maze and exaggerated startle reaction as well as corticosterone levels and mRNA BDNF and TrkB were compared in rats exposed to predator stress, microinjected with anisomycin before or after stress exposure. Administration of anisomycin before or after stress exposure reduced anxiety‐like behavior in the elevated plus‐maze and reduced the mean startle amplitude 7 days postexposure. Although the behavioral responses were similar when anisomycin was microinjected before or after stress exposure, the levels of mRNAs for BDNF and TrkB, which play a role in modulation of synaptic plasticity and the consolidation process, showed varying responses. Depression and Anxiety 0:1–11, 2007. © 2007 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>anisomycin</subject><subject>Anisomycin - pharmacology</subject><subject>anxiety-like behavior</subject><subject>Behavior, Animal - drug effects</subject><subject>brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>corticosterone</subject><subject>Corticosterone - blood</subject><subject>Fear - physiology</subject><subject>Frontal Lobe - drug effects</subject><subject>Frontal Lobe - pathology</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - pathology</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Microinjections</subject><subject>Neuronal Plasticity - drug effects</subject><subject>protein synthesis inhibitor</subject><subject>Protein Synthesis Inhibitors - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptor, trkB - genetics</subject><subject>Reflex, Startle - drug effects</subject><subject>RNA, Messenger - genetics</subject><subject>stress</subject><subject>Stress, Psychological - complications</subject><subject>TrkB</subject><issn>1091-4269</issn><issn>1520-6394</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0c1u1DAUBeAIgWgpSDwB8gqxSfFfbGdZWlqQpqULEEvLiW8YQ8ae-jql8yI8LxlmoCsEK9vyd89dnKp6zugxo5S_9u6YU6HUg-qQNZzWSrTy4XynLaslV-1B9QTxK6XUtIY-rg6YNtzohh5WP65zKhAiwU0sS8CAJMRl6EIJKZIOhpSBpEzcUCATLBkQCdytE07zx_yaxrIdIT7cQv4CsRCIPvU5RCAuevLm7Op869YpIuDM0CGmPrgCngw5reYlS3cbUnbjvXtaPRrciPBsfx5Vn87ffjx9Vy8-XLw_PVnUvRBS1Y1WDQOuuGRS66bpjfBcaN95M7hW9Uwp33WGGu5Eo0QnqW5N0wnTSi-F7sVR9XKXu87pZgIsdhWwh3F0EdKEVlOtpNTsn5AzzlnTmv-AjBqh2hm-2sE-J8QMg13nsHJ5Yxm121atd_ZXqzN9sc-cuhX4e7ivcQb1DnwPI2z-GmTPTn4H7n3AAnd_vMvfrNJCN_bz1YW9XAh2LS6NpeInHDW7mg</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>Kozlovsky, Nitsan</creator><creator>Kaplan, Zeev</creator><creator>Zohar, Joseph</creator><creator>Matar, Michael A.</creator><creator>Shimon, Hady</creator><creator>Cohen, Hagit</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20080501</creationdate><title>Protein synthesis inhibition before or after stress exposure results in divergent endocrine and BDNF responses disassociated from behavioral responses</title><author>Kozlovsky, Nitsan ; Kaplan, Zeev ; Zohar, Joseph ; Matar, Michael A. ; Shimon, Hady ; Cohen, Hagit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3346-57651e2624147755c83d237dbd8fa96c166dbb8082a3563b407985b3894d437c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>anisomycin</topic><topic>Anisomycin - pharmacology</topic><topic>anxiety-like behavior</topic><topic>Behavior, Animal - drug effects</topic><topic>brain-derived neurotrophic factor</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>corticosterone</topic><topic>Corticosterone - blood</topic><topic>Fear - physiology</topic><topic>Frontal Lobe - drug effects</topic><topic>Frontal Lobe - pathology</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - pathology</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Microinjections</topic><topic>Neuronal Plasticity - drug effects</topic><topic>protein synthesis inhibitor</topic><topic>Protein Synthesis Inhibitors - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptor, trkB - genetics</topic><topic>Reflex, Startle - drug effects</topic><topic>RNA, Messenger - genetics</topic><topic>stress</topic><topic>Stress, Psychological - complications</topic><topic>TrkB</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kozlovsky, Nitsan</creatorcontrib><creatorcontrib>Kaplan, Zeev</creatorcontrib><creatorcontrib>Zohar, Joseph</creatorcontrib><creatorcontrib>Matar, Michael A.</creatorcontrib><creatorcontrib>Shimon, Hady</creatorcontrib><creatorcontrib>Cohen, Hagit</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Depression and anxiety</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kozlovsky, Nitsan</au><au>Kaplan, Zeev</au><au>Zohar, Joseph</au><au>Matar, Michael A.</au><au>Shimon, Hady</au><au>Cohen, Hagit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protein synthesis inhibition before or after stress exposure results in divergent endocrine and BDNF responses disassociated from behavioral responses</atitle><jtitle>Depression and anxiety</jtitle><addtitle>Depress. 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Although the behavioral responses were similar when anisomycin was microinjected before or after stress exposure, the levels of mRNAs for BDNF and TrkB, which play a role in modulation of synaptic plasticity and the consolidation process, showed varying responses. Depression and Anxiety 0:1–11, 2007. © 2007 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>17828750</pmid><doi>10.1002/da.20366</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals anisomycin Anisomycin - pharmacology anxiety-like behavior Behavior, Animal - drug effects brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics corticosterone Corticosterone - blood Fear - physiology Frontal Lobe - drug effects Frontal Lobe - pathology Hippocampus - drug effects Hippocampus - pathology Male Maze Learning - drug effects Microinjections Neuronal Plasticity - drug effects protein synthesis inhibitor Protein Synthesis Inhibitors - pharmacology Rats Rats, Sprague-Dawley Receptor, trkB - genetics Reflex, Startle - drug effects RNA, Messenger - genetics stress Stress, Psychological - complications TrkB |
| title | Protein synthesis inhibition before or after stress exposure results in divergent endocrine and BDNF responses disassociated from behavioral responses |
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