Elevated levels of growth-related hormones in autism and autism spectrum disorder
Summary Objective Children with autism are known to have larger head circumferences; whether they are above average in height and weight is less clear. Moreover, little is known about growth‐related hormone levels in children with autism. We investigated whether children with autism were taller and...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2007-08, Vol.67 (2), p.230-237 |
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| creator | Mills, James L. Hediger, Mary L. Molloy, Cynthia A. Chrousos, George P. Manning-Courtney, Patricia Yu, Kai F. Brasington, Mark England, Lucinda J. |
| description | Summary
Objective Children with autism are known to have larger head circumferences; whether they are above average in height and weight is less clear. Moreover, little is known about growth‐related hormone levels in children with autism. We investigated whether children with autism were taller and heavier, and whether they had higher levels of growth‐related hormones than control children did.
Design A case‐control study design was employed.
Patients Boys with autism spectrum disorder (ASD) or autism (n = 71) and age‐matched control boys (n = 59) were evaluated at Cincinnati Children's Hospital.
Measurements Height, weight and head circumference were measured. Blood samples were assayed for IGF‐1 and 2, IGFBP‐3, growth hormone binding protein (GHBP) and for dehydroepiandrosterone (DHEA) and DHEA sulphate (DHEAS).
Results Subjects with autism/ASD had significantly (P = 0·03) greater head circumferences (mean z‐score 1·24, SD 1·35) than controls (mean z‐score 0·78, SD 0·93). Subjects with autism also had significantly (P = 0·01) greater weights (mean z‐score 0·91, SD 1·13) than controls (mean z‐score 0·41, SD 1·11). Height did not differ significantly between groups (P = 0·65); subjects with autism/ASD had significantly (P = 0·003) higher body mass indices (BMI) (mean z‐score 0·85, SD 1·19) than controls (mean z‐score 0·24, SD 1·17). Levels of IGF‐1, IGF‐2, IGFBP‐3 and GHBP in the group with autism/ASD were all significantly higher (all P ≤ 0·0001) than in controls.
Conclusions Children with autism/ASD had significantly higher levels of many growth‐related hormones: IGF‐1, IGF‐2, IGFBP‐3 and GHBP. These findings could help explain the significantly larger head circumferences and higher weights and BMIs seen in these subjects. Future studies should examine the potential role of growth‐related hormones in the pathophysiology of autism. |
| doi_str_mv | 10.1111/j.1365-2265.2007.02868.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70760423</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70760423</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5518-16bea01784ce76fe3407c4539839692b43ff1788d35eba62fd004d16c40346ab3</originalsourceid><addsrcrecordid>eNqNkMtv1DAQhy0EosvCv4BygVvC-O0cOKDV9iFVS3mpR8tJJjRLHls7odv_vk53aa_4MiPN9xvbHyEJhYzG82mbUa5kypiSGQPQGTCjTLZ_QRZPg5dkARwgBaXECXkTwhYApAH9mpxQLYVWJl-Qb-sW_7oRqyRWbEMy1MlvP9yNN6nH9nFwM_hu6DEkTZ-4aWxCl7i--teGHZajn7qkasLgK_RvyavatQHfHeuS_Dpd_1ydp5dfzy5WXy7TUkpqUqoKdEC1ESVqVSMXoEsheW54rnJWCF7XcWoqLrFwitUVgKioKgVwoVzBl-TjYe_OD7cThtF2TSixbV2PwxSsBq1AMB5BcwBLP4TgsbY733TO31sKdtZpt3a2ZmdrdtZpH3XafYy-P94xFR1Wz8Gjvwh8OAIulK6tvevLJjxzJmcsj19aks8H7q5p8f6_H2BX683cxXx6yDdhxP1T3vk_Vmmupb3enNnvp-c_NlfXV3HZA7Spn7s</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70760423</pqid></control><display><type>article</type><title>Elevated levels of growth-related hormones in autism and autism spectrum disorder</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Mills, James L. ; Hediger, Mary L. ; Molloy, Cynthia A. ; Chrousos, George P. ; Manning-Courtney, Patricia ; Yu, Kai F. ; Brasington, Mark ; England, Lucinda J.</creator><creatorcontrib>Mills, James L. ; Hediger, Mary L. ; Molloy, Cynthia A. ; Chrousos, George P. ; Manning-Courtney, Patricia ; Yu, Kai F. ; Brasington, Mark ; England, Lucinda J.</creatorcontrib><description>Summary
Objective Children with autism are known to have larger head circumferences; whether they are above average in height and weight is less clear. Moreover, little is known about growth‐related hormone levels in children with autism. We investigated whether children with autism were taller and heavier, and whether they had higher levels of growth‐related hormones than control children did.
Design A case‐control study design was employed.
Patients Boys with autism spectrum disorder (ASD) or autism (n = 71) and age‐matched control boys (n = 59) were evaluated at Cincinnati Children's Hospital.
Measurements Height, weight and head circumference were measured. Blood samples were assayed for IGF‐1 and 2, IGFBP‐3, growth hormone binding protein (GHBP) and for dehydroepiandrosterone (DHEA) and DHEA sulphate (DHEAS).
Results Subjects with autism/ASD had significantly (P = 0·03) greater head circumferences (mean z‐score 1·24, SD 1·35) than controls (mean z‐score 0·78, SD 0·93). Subjects with autism also had significantly (P = 0·01) greater weights (mean z‐score 0·91, SD 1·13) than controls (mean z‐score 0·41, SD 1·11). Height did not differ significantly between groups (P = 0·65); subjects with autism/ASD had significantly (P = 0·003) higher body mass indices (BMI) (mean z‐score 0·85, SD 1·19) than controls (mean z‐score 0·24, SD 1·17). Levels of IGF‐1, IGF‐2, IGFBP‐3 and GHBP in the group with autism/ASD were all significantly higher (all P ≤ 0·0001) than in controls.
Conclusions Children with autism/ASD had significantly higher levels of many growth‐related hormones: IGF‐1, IGF‐2, IGFBP‐3 and GHBP. These findings could help explain the significantly larger head circumferences and higher weights and BMIs seen in these subjects. Future studies should examine the potential role of growth‐related hormones in the pathophysiology of autism.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/j.1365-2265.2007.02868.x</identifier><identifier>PMID: 17547689</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adrenal Glands - physiopathology ; Autistic Disorder - blood ; Autistic Disorder - pathology ; Autistic Disorder - physiopathology ; Biological and medical sciences ; Body Mass Index ; Body Weight ; Carrier Proteins - blood ; Case-Control Studies ; Cephalometry ; Chi-Square Distribution ; Child ; Child clinical studies ; Child, Preschool ; Dehydroepiandrosterone - blood ; Dehydroepiandrosterone Sulfate - blood ; Developmental disorders ; Endocrinopathies ; Fundamental and applied biological sciences. Psychology ; Humans ; Infantile autism ; Insulin-Like Growth Factor Binding Protein 3 - blood ; Insulin-Like Growth Factor I - analysis ; Insulin-Like Growth Factor II - analysis ; Intercellular Signaling Peptides and Proteins - blood ; Male ; Medical sciences ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Vertebrates: endocrinology</subject><ispartof>Clinical endocrinology (Oxford), 2007-08, Vol.67 (2), p.230-237</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5518-16bea01784ce76fe3407c4539839692b43ff1788d35eba62fd004d16c40346ab3</citedby><cites>FETCH-LOGICAL-c5518-16bea01784ce76fe3407c4539839692b43ff1788d35eba62fd004d16c40346ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2265.2007.02868.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2265.2007.02868.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18922998$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17547689$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mills, James L.</creatorcontrib><creatorcontrib>Hediger, Mary L.</creatorcontrib><creatorcontrib>Molloy, Cynthia A.</creatorcontrib><creatorcontrib>Chrousos, George P.</creatorcontrib><creatorcontrib>Manning-Courtney, Patricia</creatorcontrib><creatorcontrib>Yu, Kai F.</creatorcontrib><creatorcontrib>Brasington, Mark</creatorcontrib><creatorcontrib>England, Lucinda J.</creatorcontrib><title>Elevated levels of growth-related hormones in autism and autism spectrum disorder</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Summary
Objective Children with autism are known to have larger head circumferences; whether they are above average in height and weight is less clear. Moreover, little is known about growth‐related hormone levels in children with autism. We investigated whether children with autism were taller and heavier, and whether they had higher levels of growth‐related hormones than control children did.
Design A case‐control study design was employed.
Patients Boys with autism spectrum disorder (ASD) or autism (n = 71) and age‐matched control boys (n = 59) were evaluated at Cincinnati Children's Hospital.
Measurements Height, weight and head circumference were measured. Blood samples were assayed for IGF‐1 and 2, IGFBP‐3, growth hormone binding protein (GHBP) and for dehydroepiandrosterone (DHEA) and DHEA sulphate (DHEAS).
Results Subjects with autism/ASD had significantly (P = 0·03) greater head circumferences (mean z‐score 1·24, SD 1·35) than controls (mean z‐score 0·78, SD 0·93). Subjects with autism also had significantly (P = 0·01) greater weights (mean z‐score 0·91, SD 1·13) than controls (mean z‐score 0·41, SD 1·11). Height did not differ significantly between groups (P = 0·65); subjects with autism/ASD had significantly (P = 0·003) higher body mass indices (BMI) (mean z‐score 0·85, SD 1·19) than controls (mean z‐score 0·24, SD 1·17). Levels of IGF‐1, IGF‐2, IGFBP‐3 and GHBP in the group with autism/ASD were all significantly higher (all P ≤ 0·0001) than in controls.
Conclusions Children with autism/ASD had significantly higher levels of many growth‐related hormones: IGF‐1, IGF‐2, IGFBP‐3 and GHBP. These findings could help explain the significantly larger head circumferences and higher weights and BMIs seen in these subjects. Future studies should examine the potential role of growth‐related hormones in the pathophysiology of autism.</description><subject>Adrenal Glands - physiopathology</subject><subject>Autistic Disorder - blood</subject><subject>Autistic Disorder - pathology</subject><subject>Autistic Disorder - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Body Weight</subject><subject>Carrier Proteins - blood</subject><subject>Case-Control Studies</subject><subject>Cephalometry</subject><subject>Chi-Square Distribution</subject><subject>Child</subject><subject>Child clinical studies</subject><subject>Child, Preschool</subject><subject>Dehydroepiandrosterone - blood</subject><subject>Dehydroepiandrosterone Sulfate - blood</subject><subject>Developmental disorders</subject><subject>Endocrinopathies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Infantile autism</subject><subject>Insulin-Like Growth Factor Binding Protein 3 - blood</subject><subject>Insulin-Like Growth Factor I - analysis</subject><subject>Insulin-Like Growth Factor II - analysis</subject><subject>Intercellular Signaling Peptides and Proteins - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Vertebrates: endocrinology</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtv1DAQhy0EosvCv4BygVvC-O0cOKDV9iFVS3mpR8tJJjRLHls7odv_vk53aa_4MiPN9xvbHyEJhYzG82mbUa5kypiSGQPQGTCjTLZ_QRZPg5dkARwgBaXECXkTwhYApAH9mpxQLYVWJl-Qb-sW_7oRqyRWbEMy1MlvP9yNN6nH9nFwM_hu6DEkTZ-4aWxCl7i--teGHZajn7qkasLgK_RvyavatQHfHeuS_Dpd_1ydp5dfzy5WXy7TUkpqUqoKdEC1ESVqVSMXoEsheW54rnJWCF7XcWoqLrFwitUVgKioKgVwoVzBl-TjYe_OD7cThtF2TSixbV2PwxSsBq1AMB5BcwBLP4TgsbY733TO31sKdtZpt3a2ZmdrdtZpH3XafYy-P94xFR1Wz8Gjvwh8OAIulK6tvevLJjxzJmcsj19aks8H7q5p8f6_H2BX683cxXx6yDdhxP1T3vk_Vmmupb3enNnvp-c_NlfXV3HZA7Spn7s</recordid><startdate>200708</startdate><enddate>200708</enddate><creator>Mills, James L.</creator><creator>Hediger, Mary L.</creator><creator>Molloy, Cynthia A.</creator><creator>Chrousos, George P.</creator><creator>Manning-Courtney, Patricia</creator><creator>Yu, Kai F.</creator><creator>Brasington, Mark</creator><creator>England, Lucinda J.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200708</creationdate><title>Elevated levels of growth-related hormones in autism and autism spectrum disorder</title><author>Mills, James L. ; Hediger, Mary L. ; Molloy, Cynthia A. ; Chrousos, George P. ; Manning-Courtney, Patricia ; Yu, Kai F. ; Brasington, Mark ; England, Lucinda J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5518-16bea01784ce76fe3407c4539839692b43ff1788d35eba62fd004d16c40346ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adrenal Glands - physiopathology</topic><topic>Autistic Disorder - blood</topic><topic>Autistic Disorder - pathology</topic><topic>Autistic Disorder - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Body Weight</topic><topic>Carrier Proteins - blood</topic><topic>Case-Control Studies</topic><topic>Cephalometry</topic><topic>Chi-Square Distribution</topic><topic>Child</topic><topic>Child clinical studies</topic><topic>Child, Preschool</topic><topic>Dehydroepiandrosterone - blood</topic><topic>Dehydroepiandrosterone Sulfate - blood</topic><topic>Developmental disorders</topic><topic>Endocrinopathies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Infantile autism</topic><topic>Insulin-Like Growth Factor Binding Protein 3 - blood</topic><topic>Insulin-Like Growth Factor I - analysis</topic><topic>Insulin-Like Growth Factor II - analysis</topic><topic>Intercellular Signaling Peptides and Proteins - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mills, James L.</creatorcontrib><creatorcontrib>Hediger, Mary L.</creatorcontrib><creatorcontrib>Molloy, Cynthia A.</creatorcontrib><creatorcontrib>Chrousos, George P.</creatorcontrib><creatorcontrib>Manning-Courtney, Patricia</creatorcontrib><creatorcontrib>Yu, Kai F.</creatorcontrib><creatorcontrib>Brasington, Mark</creatorcontrib><creatorcontrib>England, Lucinda J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mills, James L.</au><au>Hediger, Mary L.</au><au>Molloy, Cynthia A.</au><au>Chrousos, George P.</au><au>Manning-Courtney, Patricia</au><au>Yu, Kai F.</au><au>Brasington, Mark</au><au>England, Lucinda J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated levels of growth-related hormones in autism and autism spectrum disorder</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2007-08</date><risdate>2007</risdate><volume>67</volume><issue>2</issue><spage>230</spage><epage>237</epage><pages>230-237</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Objective Children with autism are known to have larger head circumferences; whether they are above average in height and weight is less clear. Moreover, little is known about growth‐related hormone levels in children with autism. We investigated whether children with autism were taller and heavier, and whether they had higher levels of growth‐related hormones than control children did.
Design A case‐control study design was employed.
Patients Boys with autism spectrum disorder (ASD) or autism (n = 71) and age‐matched control boys (n = 59) were evaluated at Cincinnati Children's Hospital.
Measurements Height, weight and head circumference were measured. Blood samples were assayed for IGF‐1 and 2, IGFBP‐3, growth hormone binding protein (GHBP) and for dehydroepiandrosterone (DHEA) and DHEA sulphate (DHEAS).
Results Subjects with autism/ASD had significantly (P = 0·03) greater head circumferences (mean z‐score 1·24, SD 1·35) than controls (mean z‐score 0·78, SD 0·93). Subjects with autism also had significantly (P = 0·01) greater weights (mean z‐score 0·91, SD 1·13) than controls (mean z‐score 0·41, SD 1·11). Height did not differ significantly between groups (P = 0·65); subjects with autism/ASD had significantly (P = 0·003) higher body mass indices (BMI) (mean z‐score 0·85, SD 1·19) than controls (mean z‐score 0·24, SD 1·17). Levels of IGF‐1, IGF‐2, IGFBP‐3 and GHBP in the group with autism/ASD were all significantly higher (all P ≤ 0·0001) than in controls.
Conclusions Children with autism/ASD had significantly higher levels of many growth‐related hormones: IGF‐1, IGF‐2, IGFBP‐3 and GHBP. These findings could help explain the significantly larger head circumferences and higher weights and BMIs seen in these subjects. Future studies should examine the potential role of growth‐related hormones in the pathophysiology of autism.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17547689</pmid><doi>10.1111/j.1365-2265.2007.02868.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adrenal Glands - physiopathology Autistic Disorder - blood Autistic Disorder - pathology Autistic Disorder - physiopathology Biological and medical sciences Body Mass Index Body Weight Carrier Proteins - blood Case-Control Studies Cephalometry Chi-Square Distribution Child Child clinical studies Child, Preschool Dehydroepiandrosterone - blood Dehydroepiandrosterone Sulfate - blood Developmental disorders Endocrinopathies Fundamental and applied biological sciences. Psychology Humans Infantile autism Insulin-Like Growth Factor Binding Protein 3 - blood Insulin-Like Growth Factor I - analysis Insulin-Like Growth Factor II - analysis Intercellular Signaling Peptides and Proteins - blood Male Medical sciences Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Vertebrates: endocrinology |
| title | Elevated levels of growth-related hormones in autism and autism spectrum disorder |
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