MRI activity and neutralising antibody as predictors of response to interferon β treatment in multiple sclerosis

Objective:To prospectively validate MRI activity and neutralising anti-interferon antibody (NAb) during the first 6 months of interferon β treatment as response indicators in multiple sclerosis (MS).Methods:Patients with relapsing–remitting MS were followed during the first 2 years of treatment. Neu...

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Veröffentlicht in:	Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2008-06, Vol.79 (6), p.646-651
Hauptverfasser:	Durelli, L, Barbero, P, Bergui, M, Versino, E, Bassano, M A, Verdun, E, Rivoiro, C, Ferrero, C, Picco, E, Ripellino, P, Giuliani, G, Montanari, E, Clerico, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - therapeutic use Adult Antibodies - blood Brain - drug effects Brain - pathology Drug Administration Schedule Female Follow-Up Studies Humans Injections, Subcutaneous Interferon beta-1b Interferon-beta - immunology Interferon-beta - therapeutic use Magnetic Resonance Imaging Male Middle Aged Multiple Sclerosis, Relapsing-Remitting - drug therapy Multiple Sclerosis, Relapsing-Remitting - immunology Neurologic Examination - drug effects Neutralization Tests Prospective Studies Recombinant Proteins - immunology Recombinant Proteins - therapeutic use Treatment Outcome
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