Germinal vesicle position and meiotic maturation in mouse oocyte
During meiotic maturation, mammalian oocytes undergo an asymmetric division which is crucial for the formation of a functional gamete. In various organisms, accurate positioning of the nucleus before M-phase plays a major role in asymmetric cell divisions. However, the role of the position of the nu...
Gespeichert in:
| Veröffentlicht in: | Reproduction (Cambridge, England) England), 2007-06, Vol.133 (6), p.1069-1072 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1072 |
|---|---|
| container_issue | 6 |
| container_start_page | 1069 |
| container_title | Reproduction (Cambridge, England) |
| container_volume | 133 |
| creator | Brunet, Stéphane Maro, Bernard |
| description | During meiotic maturation, mammalian oocytes undergo an asymmetric division which is crucial for the formation of a functional gamete. In various organisms, accurate positioning of the nucleus before M-phase plays a major role in asymmetric cell divisions. However, the role of the position of the nucleus (or germinal vesicle, GV) during the prophase I arrest has not been investigated in mammalian oocytes. Here, we show that incompetent mouse oocytes possess a peripheral GV, while competent oocytes mainly exhibit a central position of the GV. At that time, the position of the GV correlates with the ability of the oocyte to complete meiotic maturation. Moreover, a lower efficiency in GV centering and a reduced ability to progress through meiosis are observed in oocytes from old mice. Thus, the position of the GV could be used as a simple morphological marker of oocyte quality. |
| doi_str_mv | 10.1530/REP-07-0036 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70759621</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19712117</sourcerecordid><originalsourceid>FETCH-LOGICAL-b563t-5fc80d4b9893440eae8467d1edac82847157d75193309b89f341d06aada2ec733</originalsourceid><addsrcrecordid>eNqF0U1v1DAQBmALteoXPXGnOXFBoTNx4olvoKoUpEqtWnq2HGfSGiXx1s6C-u_JNotAHOjJlvXMq9FrId4gfMBKwunN-XUOlANI9UocIJWYU631znwvCXJUhdoXhyl9B8CqJrUn9pGUVKjwQHy84Dj40fbZD07e9ZytQvKTD2NmxzYb2IfJu2yw0zra52c_ZkNYJ85CcE8Tvxa7ne0TH2_PI3H3-fzb2Zf88uri69mny7yplJzyqnM1tGWjay3LEthyXSpqkVvr6qIuCStqqUItJeim1p0ssQVlbWsLdiTlkXi35K5ieFxzmszgk-O-tyPP6xgCqrQq8EWImrBApBm-X6CLIaXInVlFP9j4ZBDMplkzN2uAzKbZWb_dxq6bgds_dlvlDIoFPPj7h58-sml8SM7zOPnOO_t36u__modOlqHOBmPvo0_m7rYAlACkUemNwEX8k_a_XX8BL9mcSw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19712117</pqid></control><display><type>article</type><title>Germinal vesicle position and meiotic maturation in mouse oocyte</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Brunet, Stéphane ; Maro, Bernard</creator><creatorcontrib>Brunet, Stéphane ; Maro, Bernard</creatorcontrib><description>During meiotic maturation, mammalian oocytes undergo an asymmetric division which is crucial for the formation of a functional gamete. In various organisms, accurate positioning of the nucleus before M-phase plays a major role in asymmetric cell divisions. However, the role of the position of the nucleus (or germinal vesicle, GV) during the prophase I arrest has not been investigated in mammalian oocytes. Here, we show that incompetent mouse oocytes possess a peripheral GV, while competent oocytes mainly exhibit a central position of the GV. At that time, the position of the GV correlates with the ability of the oocyte to complete meiotic maturation. Moreover, a lower efficiency in GV centering and a reduced ability to progress through meiosis are observed in oocytes from old mice. Thus, the position of the GV could be used as a simple morphological marker of oocyte quality.</description><identifier>ISSN: 1470-1626</identifier><identifier>EISSN: 1741-7899</identifier><identifier>DOI: 10.1530/REP-07-0036</identifier><identifier>PMID: 17636161</identifier><language>eng</language><publisher>England: Society for Reproduction and Fertility</publisher><subject>Animals ; Cell Nucleus - ultrastructure ; Cell Survival ; Cells, Cultured ; Female ; Mammals - physiology ; Maternal Age ; Meiotic Prophase I ; Mice ; Oocytes - ultrastructure ; Oogenesis - physiology ; SHORT COMMUNICATION</subject><ispartof>Reproduction (Cambridge, England), 2007-06, Vol.133 (6), p.1069-1072</ispartof><rights>2007 Society for Reproduction and Fertility</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b563t-5fc80d4b9893440eae8467d1edac82847157d75193309b89f341d06aada2ec733</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17636161$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brunet, Stéphane</creatorcontrib><creatorcontrib>Maro, Bernard</creatorcontrib><title>Germinal vesicle position and meiotic maturation in mouse oocyte</title><title>Reproduction (Cambridge, England)</title><addtitle>Reproduction</addtitle><description>During meiotic maturation, mammalian oocytes undergo an asymmetric division which is crucial for the formation of a functional gamete. In various organisms, accurate positioning of the nucleus before M-phase plays a major role in asymmetric cell divisions. However, the role of the position of the nucleus (or germinal vesicle, GV) during the prophase I arrest has not been investigated in mammalian oocytes. Here, we show that incompetent mouse oocytes possess a peripheral GV, while competent oocytes mainly exhibit a central position of the GV. At that time, the position of the GV correlates with the ability of the oocyte to complete meiotic maturation. Moreover, a lower efficiency in GV centering and a reduced ability to progress through meiosis are observed in oocytes from old mice. Thus, the position of the GV could be used as a simple morphological marker of oocyte quality.</description><subject>Animals</subject><subject>Cell Nucleus - ultrastructure</subject><subject>Cell Survival</subject><subject>Cells, Cultured</subject><subject>Female</subject><subject>Mammals - physiology</subject><subject>Maternal Age</subject><subject>Meiotic Prophase I</subject><subject>Mice</subject><subject>Oocytes - ultrastructure</subject><subject>Oogenesis - physiology</subject><subject>SHORT COMMUNICATION</subject><issn>1470-1626</issn><issn>1741-7899</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1v1DAQBmALteoXPXGnOXFBoTNx4olvoKoUpEqtWnq2HGfSGiXx1s6C-u_JNotAHOjJlvXMq9FrId4gfMBKwunN-XUOlANI9UocIJWYU631znwvCXJUhdoXhyl9B8CqJrUn9pGUVKjwQHy84Dj40fbZD07e9ZytQvKTD2NmxzYb2IfJu2yw0zra52c_ZkNYJ85CcE8Tvxa7ne0TH2_PI3H3-fzb2Zf88uri69mny7yplJzyqnM1tGWjay3LEthyXSpqkVvr6qIuCStqqUItJeim1p0ssQVlbWsLdiTlkXi35K5ieFxzmszgk-O-tyPP6xgCqrQq8EWImrBApBm-X6CLIaXInVlFP9j4ZBDMplkzN2uAzKbZWb_dxq6bgds_dlvlDIoFPPj7h58-sml8SM7zOPnOO_t36u__modOlqHOBmPvo0_m7rYAlACkUemNwEX8k_a_XX8BL9mcSw</recordid><startdate>20070601</startdate><enddate>20070601</enddate><creator>Brunet, Stéphane</creator><creator>Maro, Bernard</creator><general>Society for Reproduction and Fertility</general><general>BioScientifica Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20070601</creationdate><title>Germinal vesicle position and meiotic maturation in mouse oocyte</title><author>Brunet, Stéphane ; Maro, Bernard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b563t-5fc80d4b9893440eae8467d1edac82847157d75193309b89f341d06aada2ec733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Cell Nucleus - ultrastructure</topic><topic>Cell Survival</topic><topic>Cells, Cultured</topic><topic>Female</topic><topic>Mammals - physiology</topic><topic>Maternal Age</topic><topic>Meiotic Prophase I</topic><topic>Mice</topic><topic>Oocytes - ultrastructure</topic><topic>Oogenesis - physiology</topic><topic>SHORT COMMUNICATION</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brunet, Stéphane</creatorcontrib><creatorcontrib>Maro, Bernard</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Reproduction (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brunet, Stéphane</au><au>Maro, Bernard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Germinal vesicle position and meiotic maturation in mouse oocyte</atitle><jtitle>Reproduction (Cambridge, England)</jtitle><addtitle>Reproduction</addtitle><date>2007-06-01</date><risdate>2007</risdate><volume>133</volume><issue>6</issue><spage>1069</spage><epage>1072</epage><pages>1069-1072</pages><issn>1470-1626</issn><eissn>1741-7899</eissn><abstract>During meiotic maturation, mammalian oocytes undergo an asymmetric division which is crucial for the formation of a functional gamete. In various organisms, accurate positioning of the nucleus before M-phase plays a major role in asymmetric cell divisions. However, the role of the position of the nucleus (or germinal vesicle, GV) during the prophase I arrest has not been investigated in mammalian oocytes. Here, we show that incompetent mouse oocytes possess a peripheral GV, while competent oocytes mainly exhibit a central position of the GV. At that time, the position of the GV correlates with the ability of the oocyte to complete meiotic maturation. Moreover, a lower efficiency in GV centering and a reduced ability to progress through meiosis are observed in oocytes from old mice. Thus, the position of the GV could be used as a simple morphological marker of oocyte quality.</abstract><cop>England</cop><pub>Society for Reproduction and Fertility</pub><pmid>17636161</pmid><doi>10.1530/REP-07-0036</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1470-1626 |
| ispartof | Reproduction (Cambridge, England), 2007-06, Vol.133 (6), p.1069-1072 |
| issn | 1470-1626 1741-7899 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70759621 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Cell Nucleus - ultrastructure Cell Survival Cells, Cultured Female Mammals - physiology Maternal Age Meiotic Prophase I Mice Oocytes - ultrastructure Oogenesis - physiology SHORT COMMUNICATION |
| title | Germinal vesicle position and meiotic maturation in mouse oocyte |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T01%3A31%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Germinal%20vesicle%20position%20and%20meiotic%20maturation%20in%20mouse%20oocyte&rft.jtitle=Reproduction%20(Cambridge,%20England)&rft.au=Brunet,%20Ste%CC%81phane&rft.date=2007-06-01&rft.volume=133&rft.issue=6&rft.spage=1069&rft.epage=1072&rft.pages=1069-1072&rft.issn=1470-1626&rft.eissn=1741-7899&rft_id=info:doi/10.1530/REP-07-0036&rft_dat=%3Cproquest_cross%3E19712117%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19712117&rft_id=info:pmid/17636161&rfr_iscdi=true |