Neuregulin Family of Genes and their Multiple Splice Variants in Breast Cancer

The neuregulin family consists of four genes, NRG1-4 which can each encode products containing a domain related to the epidermal growth factor family of ligands. Each gene is subject to complex control of transcription and to splicing of their mRNA product to give many variant proteins. These do not...

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Veröffentlicht in:	Journal of mammary gland biology and neoplasia 2008-06, Vol.13 (2), p.205-214
Hauptverfasser:	Hayes, Nandini V. L, Gullick, William J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Animals Breast cancer breast neoplasms Breast Neoplasms - genetics Breast Neoplasms - metabolism Cancer Research Female Heregulin Humans Ligands Medicine Medicine & Public Health Mice Neuregulin Neuregulin-1 - genetics Neuregulin-1 - metabolism Neuregulins - genetics Neuregulins - metabolism Oncology Protein Isoforms - genetics Protein Isoforms - metabolism Receptor, Epidermal Growth Factor - metabolism Splicing
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