Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands

Non-selective benzodiazepines, such as diazepam, interact with equivalent affinity and agonist efficacy at GABA(A) receptors containing either an alpha1, alpha2, alpha3 or alpha5 subunit. However, which of these particular subtypes are responsible for the anticonvulsant effects of diazepam remains u...

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Veröffentlicht in:	Journal of psychopharmacology (Oxford) 2007-06, Vol.21 (4), p.384-391
Hauptverfasser:	Fradley, Rosa L, Guscott, Martin R, Bull, Sharlene, Hallett, David J, Goodacre, Simon C, Wafford, Keith A, Garrett, Elizabeth M, Newman, Richard J, O'Meara, Gillian F, Whiting, Paul J, Rosahl, Thomas W, Dawson, Gerard R, Reynolds, David S, Atack, John R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - pharmacology Benzodiazepines - pharmacology Binding Sites Convulsants Diazepam - pharmacology Electroshock GABA-A Receptor Agonists Ligands Mice Mice, Mutant Strains Mice, Transgenic Pentylenetetrazole Point Mutation Protein Subunits - agonists Protein Subunits - genetics Protein Subunits - physiology Pyridines - pharmacology Receptors, GABA-A - genetics Receptors, GABA-A - physiology Seizures - etiology Seizures - prevention & control
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