Polar Radical Pair Pathway To Assemble the Pyrimidinone Core of the HIV Integrase Inhibitor Raltegravir Potassium

Break up to make up: Combined experimental and computational studies provide evidence that the key step in the synthesis of a novel anti‐HIV drug involves an unprecedented stepwise radical pair rearrangement mechanism in which radical fragments are held together by strong electrostatic forces (see s...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2008-05, Vol.47 (22), p.4134-4136
Hauptverfasser:	Pye, Philip J, Zhong, Yong-Li, Jones, Gavin O, Reamer, Robert A, Houk, Kendall N, Askin, David
Format:	Artikel
Sprache:	eng
Schlagworte:	density functional calculations heterocycles HIV Integrase Inhibitors - chemical synthesis HIV Integrase Inhibitors - chemistry inhibitors Organic Chemicals - chemical synthesis Organic Chemicals - chemistry pericyclic reaction Potassium - chemistry Pyrimidinones - chemical synthesis Pyrimidinones - chemistry Pyrrolidinones radicals Raltegravir Potassium
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