Effect of Hyponatremia (<135 mEq/L) on Outcome in Patients With Non–ST-Elevation Acute Coronary Syndrome
Hyponatremia is associated with adverse outcomes in patients with heart failure and ST-elevation myocardial infarction (STEMI). We evaluated the effect of hyponatremia on outcomes in patients with suspected acute coronary syndrome and non-STEMI. All patients had a sodium level determined at time of...
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| Veröffentlicht in: | The American journal of cardiology 2007-08, Vol.100 (3), p.406-408 |
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| container_title | The American journal of cardiology |
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| creator | Singla, Ish, MD Zahid, Maliha, MD Good, Chester B., MD, MPh Macioce, Alanna Sonel, Ali F., MD |
| description | Hyponatremia is associated with adverse outcomes in patients with heart failure and ST-elevation myocardial infarction (STEMI). We evaluated the effect of hyponatremia on outcomes in patients with suspected acute coronary syndrome and non-STEMI. All patients had a sodium level determined at time of admission, at 24 and 48 hours, and at discharge. Of 1,478 patients, 341 (23.1%) were hyponatremic (sodium |
| doi_str_mv | 10.1016/j.amjcard.2007.03.039 |
| format | Article |
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We evaluated the effect of hyponatremia on outcomes in patients with suspected acute coronary syndrome and non-STEMI. All patients had a sodium level determined at time of admission, at 24 and 48 hours, and at discharge. Of 1,478 patients, 341 (23.1%) were hyponatremic (sodium <135 mEq/L) on presentation. Patients who had hyponatremia on admission were significantly more likely to die or have recurrent myocardial infarction in the next 30 days (odds ratio 1.98, 95% confidence interval 1.35 to 2.89, p <0.001). This relation persisted after adjusting for factors such as age, left ventricular ejection fraction, use of diuretics before admission, hypotension on presentation, anemia, chronic renal insufficiency, pulmonary edema, and high troponin levels (odds ratio 1.7, 95% confidence interval 1.1 to 2.5, p = 0.01). In conclusion, hyponatremia on admission is associated with 30-day adverse outcome in patients presenting with suspected acute coronary syndrome/non-STEMI.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2007.03.039</identifier><identifier>PMID: 17659918</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acute coronary syndromes ; Aged ; Angina, Unstable - complications ; Cardiovascular ; Clinical outcomes ; Effects ; Electrocardiography ; Female ; Humans ; Hyponatremia - complications ; Male ; Middle Aged ; Myocardial Infarction - complications ; Myocardial Infarction - mortality ; Odds Ratio ; Patient admissions ; Prognosis ; Recurrence</subject><ispartof>The American journal of cardiology, 2007-08, Vol.100 (3), p.406-408</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><rights>Copyright Elsevier Sequoia S.A. Aug 1, 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-568dd6f9b44ed5ba8c87d5db3f8b06601ceb757574bd1665cc22623db4a346a23</citedby><cites>FETCH-LOGICAL-c445t-568dd6f9b44ed5ba8c87d5db3f8b06601ceb757574bd1665cc22623db4a346a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.amjcard.2007.03.039$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17659918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singla, Ish, MD</creatorcontrib><creatorcontrib>Zahid, Maliha, MD</creatorcontrib><creatorcontrib>Good, Chester B., MD, MPh</creatorcontrib><creatorcontrib>Macioce, Alanna</creatorcontrib><creatorcontrib>Sonel, Ali F., MD</creatorcontrib><title>Effect of Hyponatremia (<135 mEq/L) on Outcome in Patients With Non–ST-Elevation Acute Coronary Syndrome</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>Hyponatremia is associated with adverse outcomes in patients with heart failure and ST-elevation myocardial infarction (STEMI). We evaluated the effect of hyponatremia on outcomes in patients with suspected acute coronary syndrome and non-STEMI. All patients had a sodium level determined at time of admission, at 24 and 48 hours, and at discharge. Of 1,478 patients, 341 (23.1%) were hyponatremic (sodium <135 mEq/L) on presentation. Patients who had hyponatremia on admission were significantly more likely to die or have recurrent myocardial infarction in the next 30 days (odds ratio 1.98, 95% confidence interval 1.35 to 2.89, p <0.001). This relation persisted after adjusting for factors such as age, left ventricular ejection fraction, use of diuretics before admission, hypotension on presentation, anemia, chronic renal insufficiency, pulmonary edema, and high troponin levels (odds ratio 1.7, 95% confidence interval 1.1 to 2.5, p = 0.01). In conclusion, hyponatremia on admission is associated with 30-day adverse outcome in patients presenting with suspected acute coronary syndrome/non-STEMI.</description><subject>Acute coronary syndromes</subject><subject>Aged</subject><subject>Angina, Unstable - complications</subject><subject>Cardiovascular</subject><subject>Clinical outcomes</subject><subject>Effects</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Humans</subject><subject>Hyponatremia - complications</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - mortality</subject><subject>Odds Ratio</subject><subject>Patient admissions</subject><subject>Prognosis</subject><subject>Recurrence</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUtGK1DAUDaK44-onKMEH0YfOJk2TtiDKMoyuMLjCrPgY0uQWU9tmNmkX5s1_8A_9Eu8wg8K-SG64hJxzknvPJeQ5Z0vOuLrolmborIlumTNWLpnAqB-QBa_KOuM1Fw_JgjGWZzUv6jPyJKUOj5xL9Zic8VLJuubVgnTrtgU70dDSq_0ujGaKMHhDX7_lQtJhfXuxeUPDSK_nyYYBqB_pFzN5GKdEv_npO_0cxt8_f21vsnUPd3iD2Es7T0BXIaJc3NPtfnQRuU_Jo9b0CZ6d8jn5-mF9s7rKNtcfP60uN5ktCjllUlXOqbZuigKcbExlq9JJ14i2aphSjFtoSomraBxXSlqb5yoXrimMKJTJxTl5ddTdxXA7Q5r04JOFvjcjhDnpkiEZNwJf3gN2YY4j_k3ngglV5apGkDyCbAwpRWj1LvoB69Kc6YMTutMnJ_TBCc0ExoH34iQ-NwO4f6xT6xHw_ggA7MWdh6iTxb5acD6iI9oF_98n3t1TsL0fvTX9D9hD-lsM1ynXTG8P43CYBlYyVuEgiD-G77B5</recordid><startdate>20070801</startdate><enddate>20070801</enddate><creator>Singla, Ish, MD</creator><creator>Zahid, Maliha, MD</creator><creator>Good, Chester B., MD, MPh</creator><creator>Macioce, Alanna</creator><creator>Sonel, Ali F., MD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20070801</creationdate><title>Effect of Hyponatremia (<135 mEq/L) on Outcome in Patients With Non–ST-Elevation Acute Coronary Syndrome</title><author>Singla, Ish, MD ; Zahid, Maliha, MD ; Good, Chester B., MD, MPh ; Macioce, Alanna ; Sonel, Ali F., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-568dd6f9b44ed5ba8c87d5db3f8b06601ceb757574bd1665cc22623db4a346a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Acute coronary syndromes</topic><topic>Aged</topic><topic>Angina, Unstable - complications</topic><topic>Cardiovascular</topic><topic>Clinical outcomes</topic><topic>Effects</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Humans</topic><topic>Hyponatremia - complications</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - complications</topic><topic>Myocardial Infarction - mortality</topic><topic>Odds Ratio</topic><topic>Patient admissions</topic><topic>Prognosis</topic><topic>Recurrence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singla, Ish, MD</creatorcontrib><creatorcontrib>Zahid, Maliha, MD</creatorcontrib><creatorcontrib>Good, Chester B., MD, MPh</creatorcontrib><creatorcontrib>Macioce, Alanna</creatorcontrib><creatorcontrib>Sonel, Ali F., MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singla, Ish, MD</au><au>Zahid, Maliha, MD</au><au>Good, Chester B., MD, MPh</au><au>Macioce, Alanna</au><au>Sonel, Ali F., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Hyponatremia (<135 mEq/L) on Outcome in Patients With Non–ST-Elevation Acute Coronary Syndrome</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2007-08-01</date><risdate>2007</risdate><volume>100</volume><issue>3</issue><spage>406</spage><epage>408</epage><pages>406-408</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>Hyponatremia is associated with adverse outcomes in patients with heart failure and ST-elevation myocardial infarction (STEMI). We evaluated the effect of hyponatremia on outcomes in patients with suspected acute coronary syndrome and non-STEMI. All patients had a sodium level determined at time of admission, at 24 and 48 hours, and at discharge. Of 1,478 patients, 341 (23.1%) were hyponatremic (sodium <135 mEq/L) on presentation. Patients who had hyponatremia on admission were significantly more likely to die or have recurrent myocardial infarction in the next 30 days (odds ratio 1.98, 95% confidence interval 1.35 to 2.89, p <0.001). This relation persisted after adjusting for factors such as age, left ventricular ejection fraction, use of diuretics before admission, hypotension on presentation, anemia, chronic renal insufficiency, pulmonary edema, and high troponin levels (odds ratio 1.7, 95% confidence interval 1.1 to 2.5, p = 0.01). In conclusion, hyponatremia on admission is associated with 30-day adverse outcome in patients presenting with suspected acute coronary syndrome/non-STEMI.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>17659918</pmid><doi>10.1016/j.amjcard.2007.03.039</doi><tpages>3</tpages></addata></record> |
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| subjects | Acute coronary syndromes Aged Angina, Unstable - complications Cardiovascular Clinical outcomes Effects Electrocardiography Female Humans Hyponatremia - complications Male Middle Aged Myocardial Infarction - complications Myocardial Infarction - mortality Odds Ratio Patient admissions Prognosis Recurrence |
| title | Effect of Hyponatremia (<135 mEq/L) on Outcome in Patients With Non–ST-Elevation Acute Coronary Syndrome |
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