Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates

Understanding the physical characteristics of the local microenvironment in which Mycobacterium tuberculosis resides is an important goal that may allow the targeting of metabolic processes to shorten drug regimens. Pimonidazole hydrochloride (Hypoxyprobe) is an imaging agent that is bioreductively...

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Veröffentlicht in:	Infection and Immunity 2008-06, Vol.76 (6), p.2333-2340
Hauptverfasser:	Via, Laura E, Lin, P. Ling, Ray, Sonja M, Carrillo, Jose, Allen, Shannon Sedberry, Eum, Seok Yong, Taylor, Kimberly, Klein, Edwin, Manjunatha, Ujjini, Gonzales, Jacqueline, Lee, Eun Gae, Park, Seung Kyu, Raleigh, James A, Cho, Sang Nae, McMurray, David N, Flynn, JoAnne L, Barry, Clifton E. III
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Bacterial diseases Bacterial Infections Biological and medical sciences Disease Models, Animal Fundamental and applied biological sciences. Psychology Granuloma - drug therapy Granuloma - metabolism Granuloma - pathology Guinea Pigs Human bacterial diseases Humans Hypoxia - diagnosis Hypoxia - metabolism Hypoxia - pathology Immunohistochemistry Infectious diseases Lung - pathology Macaca fascicularis Medical sciences Metronidazole - pharmacology Metronidazole - therapeutic use Mice Mice, Inbred BALB C Mice, Inbred C57BL Microbiology Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Nitroimidazoles Oxygen - analysis Oxygen - metabolism Primates Rabbits Radiation-Sensitizing Agents Tuberculosis and atypical mycobacterial infections Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - metabolism Tuberculosis, Pulmonary - pathology
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