Late-onset endothelin receptor blockade in hypertensive heterozygous REN-2 transgenic rats

Abstract Our previous studies in heterozygous Ren-2 transgenic rats (TGR) have shown that early treatment with selective endothelin (ET)A receptor blockade is superior to nonselective ETA/B receptor blockade. The aim of this study was to evaluate the role of the ET system in male heterozygous TGR wi...

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Veröffentlicht in:	Vascular pharmacology 2008-04, Vol.48 (4), p.165-173
Hauptverfasser:	Vernerová, Zdenka, Kramer, Herbert J, Bäcker, Angela, Červenka, Luděk, Opočenský, Martin, Husková, Zuzana, Vaňourková, Zdeňka, Eis, Václav, Chábová, Věra Čertíková, Tesař, Vladimír, Malý, Jan, Vaněčková, Ivana
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - physiology Animals Animals, Genetically Modified Blood Pressure - drug effects Blood Pressure - genetics Body Weight - genetics Cardiovascular End-organ damage Endothelin Receptor Antagonists Endothelin-1 - metabolism ET A and ET B receptors Glomerulosclerosis, Focal Segmental - pathology Heterozygote Heterozygous transgenic Ren-2 rats Hypertension Hypertension, Malignant - drug therapy Hypertension, Malignant - genetics Hypertension, Malignant - pathology Immunohistochemistry Kidney - pathology Male Microscopy, Electron Organ Size - genetics Podocytes Proteinuria - genetics Rats Rats, Sprague-Dawley Renin - genetics Renin - physiology Sodium, Dietary - pharmacology Survival Rate
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