Analgesic and anti-inflammatory activities of aqueous extract from Glycine tomentella root in mice
In the present study, we have investigated the analgesic effect of the aqueous extract of the root of Glycine tomentella (AGT) using models of acetic acid-induced writhing response and formalin test, the anti-inflammatory effect of AGT using model of λ-carrageenan-induced paw edema. In order to inve...
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| Veröffentlicht in: | Journal of ethnopharmacology 2007-08, Vol.113 (1), p.142-148 |
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| creator | Lu, Tsung-Chun Ko, Yu-Zen Huang, Hsin-Wei Hung, Ying-Chun Lin, Ying-Chih Peng, Wen-Huang |
| description | In the present study, we have investigated the analgesic effect of the aqueous extract of the root of
Glycine tomentella (AGT) using models of acetic acid-induced writhing response and formalin test, the anti-inflammatory effect of AGT using model of λ-carrageenan-induced paw edema. In order to investigate the anti-inflammatory mechanism of AGT, we have detected the activities of glutathione peroxidase (GPx) and glutathione reductase (GRx) in the liver and the levels of malondialdehyde (MDA) and NO in the edema paw.
In the analgesic test, AGT (0.5 and 1.0
g/kg) decreased the acetic acid-induced writhing response and the licking time on the late phase in the formalin test. In the anti-inflammatory test, AGT (0.5 and 1.0
g/kg) decreased the paw edema at the third, fourth, fifth and sixth hour after λ-carrageenan administration, and increased the activities of SOD, GPx and GRx in the liver tissue and decreased the MDA level in the edema paw at the third hour after λ-carrageenan injection. However, AGT could not affect the NO level which induced by λ-carrageenan.
These results suggested that AGT possessed analgesic and anti-inflammatory effects. The anti-inflammatory mechanism of AGT might be related to the decrease in the level of MDA in the edema paw
via increasing the activities of SOD, GPx and GRx in the liver. |
| doi_str_mv | 10.1016/j.jep.2007.05.024 |
| format | Article |
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Glycine tomentella (AGT) using models of acetic acid-induced writhing response and formalin test, the anti-inflammatory effect of AGT using model of λ-carrageenan-induced paw edema. In order to investigate the anti-inflammatory mechanism of AGT, we have detected the activities of glutathione peroxidase (GPx) and glutathione reductase (GRx) in the liver and the levels of malondialdehyde (MDA) and NO in the edema paw.
In the analgesic test, AGT (0.5 and 1.0
g/kg) decreased the acetic acid-induced writhing response and the licking time on the late phase in the formalin test. In the anti-inflammatory test, AGT (0.5 and 1.0
g/kg) decreased the paw edema at the third, fourth, fifth and sixth hour after λ-carrageenan administration, and increased the activities of SOD, GPx and GRx in the liver tissue and decreased the MDA level in the edema paw at the third hour after λ-carrageenan injection. However, AGT could not affect the NO level which induced by λ-carrageenan.
These results suggested that AGT possessed analgesic and anti-inflammatory effects. The anti-inflammatory mechanism of AGT might be related to the decrease in the level of MDA in the edema paw
via increasing the activities of SOD, GPx and GRx in the liver.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2007.05.024</identifier><identifier>PMID: 17616291</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Acetic Acid ; Analgesia ; analgesic effect ; Analgesics - administration & dosage ; Analgesics - pharmacology ; Animals ; Anti-inflammation ; anti-inflammatory activity ; Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - pharmacology ; bioassays ; Biological and medical sciences ; Carrageenan ; chemical constituents of plants ; Edema - drug therapy ; Fabaceae - chemistry ; Formaldehyde ; General pharmacology ; Glutathione Peroxidase - drug effects ; Glutathione Peroxidase - metabolism ; Glutathione Reductase - drug effects ; Glutathione Reductase - metabolism ; Glycine tomentella ; Inflammation - drug therapy ; Liver - drug effects ; Liver - metabolism ; Male ; Malondialdehyde - metabolism ; MDA ; Medical sciences ; medicinal plants ; medicinal properties ; Mice ; Mice, Inbred ICR ; Nitric Oxide - metabolism ; Pain - drug therapy ; Pain Measurement ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; plant extracts ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Plant Roots ; roots ; SOD ; Superoxide Dismutase - drug effects ; Superoxide Dismutase - metabolism ; Time Factors</subject><ispartof>Journal of ethnopharmacology, 2007-08, Vol.113 (1), p.142-148</ispartof><rights>2007 Elsevier Ireland Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-5834e47ef3e17f8ca8fd50be356a79ecfabfd5efdb10712027cc7595e90447943</citedby><cites>FETCH-LOGICAL-c405t-5834e47ef3e17f8ca8fd50be356a79ecfabfd5efdb10712027cc7595e90447943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2007.05.024$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18968308$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17616291$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Tsung-Chun</creatorcontrib><creatorcontrib>Ko, Yu-Zen</creatorcontrib><creatorcontrib>Huang, Hsin-Wei</creatorcontrib><creatorcontrib>Hung, Ying-Chun</creatorcontrib><creatorcontrib>Lin, Ying-Chih</creatorcontrib><creatorcontrib>Peng, Wen-Huang</creatorcontrib><title>Analgesic and anti-inflammatory activities of aqueous extract from Glycine tomentella root in mice</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>In the present study, we have investigated the analgesic effect of the aqueous extract of the root of
Glycine tomentella (AGT) using models of acetic acid-induced writhing response and formalin test, the anti-inflammatory effect of AGT using model of λ-carrageenan-induced paw edema. In order to investigate the anti-inflammatory mechanism of AGT, we have detected the activities of glutathione peroxidase (GPx) and glutathione reductase (GRx) in the liver and the levels of malondialdehyde (MDA) and NO in the edema paw.
In the analgesic test, AGT (0.5 and 1.0
g/kg) decreased the acetic acid-induced writhing response and the licking time on the late phase in the formalin test. In the anti-inflammatory test, AGT (0.5 and 1.0
g/kg) decreased the paw edema at the third, fourth, fifth and sixth hour after λ-carrageenan administration, and increased the activities of SOD, GPx and GRx in the liver tissue and decreased the MDA level in the edema paw at the third hour after λ-carrageenan injection. However, AGT could not affect the NO level which induced by λ-carrageenan.
These results suggested that AGT possessed analgesic and anti-inflammatory effects. The anti-inflammatory mechanism of AGT might be related to the decrease in the level of MDA in the edema paw
via increasing the activities of SOD, GPx and GRx in the liver.</description><subject>Acetic Acid</subject><subject>Analgesia</subject><subject>analgesic effect</subject><subject>Analgesics - administration & dosage</subject><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>Anti-inflammation</subject><subject>anti-inflammatory activity</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>bioassays</subject><subject>Biological and medical sciences</subject><subject>Carrageenan</subject><subject>chemical constituents of plants</subject><subject>Edema - drug therapy</subject><subject>Fabaceae - chemistry</subject><subject>Formaldehyde</subject><subject>General pharmacology</subject><subject>Glutathione Peroxidase - drug effects</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Glutathione Reductase - drug effects</subject><subject>Glutathione Reductase - metabolism</subject><subject>Glycine tomentella</subject><subject>Inflammation - drug therapy</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>MDA</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Nitric Oxide - metabolism</subject><subject>Pain - drug therapy</subject><subject>Pain Measurement</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>plant extracts</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Roots</subject><subject>roots</subject><subject>SOD</subject><subject>Superoxide Dismutase - drug effects</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Time Factors</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v3CAQhlHUKtl8_IBeWi7Nze5gg8HqKYratFKkHtqcEcZDxMo2W2Cj7L8v1q6UWw9oJHhmeOch5AODmgHrvmzrLe7qBkDWIGpo-BnZMCWbSgrZviMbaKWqlOTsglymtIUCMg7n5ILJjnVNzzZkuFvM9IzJW2qWsZzsK7-4ycyzySEeqLHZv_jsMdHgqPm7x7BPFF9zLC_UxTDTh-lg_YI0hxmXjNNkaAwhU7_Q2Vu8Ju-dmRLenOoVefr-7c_9j-rx18PP-7vHynIQuRKq5cgluhaZdMoa5UYBA7aiM7JH68xQLtCNAytrNNBIa6XoBfbAuex5e0Vuj3N3MZSYKevZJ7vGWdbMWoIUQsAKsiNoY0gpotO76GcTD5qBXsXqrS5i9SpWg9BFbOn5eBq-H2Yc3zpOJgvw-QSYZM3kolmsT2-c6jvVgircpyPnTNDmORbm6XcDrC2f9YrzphBfjwQWWS8eo07W42Jx9BFt1mPw_wn6D_H0oH0</recordid><startdate>20070815</startdate><enddate>20070815</enddate><creator>Lu, Tsung-Chun</creator><creator>Ko, Yu-Zen</creator><creator>Huang, Hsin-Wei</creator><creator>Hung, Ying-Chun</creator><creator>Lin, Ying-Chih</creator><creator>Peng, Wen-Huang</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070815</creationdate><title>Analgesic and anti-inflammatory activities of aqueous extract from Glycine tomentella root in mice</title><author>Lu, Tsung-Chun ; Ko, Yu-Zen ; Huang, Hsin-Wei ; Hung, Ying-Chun ; Lin, Ying-Chih ; Peng, Wen-Huang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-5834e47ef3e17f8ca8fd50be356a79ecfabfd5efdb10712027cc7595e90447943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Acetic Acid</topic><topic>Analgesia</topic><topic>analgesic effect</topic><topic>Analgesics - administration & dosage</topic><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Anti-inflammation</topic><topic>anti-inflammatory activity</topic><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>bioassays</topic><topic>Biological and medical sciences</topic><topic>Carrageenan</topic><topic>chemical constituents of plants</topic><topic>Edema - drug therapy</topic><topic>Fabaceae - chemistry</topic><topic>Formaldehyde</topic><topic>General pharmacology</topic><topic>Glutathione Peroxidase - drug effects</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Glutathione Reductase - drug effects</topic><topic>Glutathione Reductase - metabolism</topic><topic>Glycine tomentella</topic><topic>Inflammation - drug therapy</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>MDA</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Nitric Oxide - metabolism</topic><topic>Pain - drug therapy</topic><topic>Pain Measurement</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>plant extracts</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Roots</topic><topic>roots</topic><topic>SOD</topic><topic>Superoxide Dismutase - drug effects</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Tsung-Chun</creatorcontrib><creatorcontrib>Ko, Yu-Zen</creatorcontrib><creatorcontrib>Huang, Hsin-Wei</creatorcontrib><creatorcontrib>Hung, Ying-Chun</creatorcontrib><creatorcontrib>Lin, Ying-Chih</creatorcontrib><creatorcontrib>Peng, Wen-Huang</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Tsung-Chun</au><au>Ko, Yu-Zen</au><au>Huang, Hsin-Wei</au><au>Hung, Ying-Chun</au><au>Lin, Ying-Chih</au><au>Peng, Wen-Huang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analgesic and anti-inflammatory activities of aqueous extract from Glycine tomentella root in mice</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2007-08-15</date><risdate>2007</risdate><volume>113</volume><issue>1</issue><spage>142</spage><epage>148</epage><pages>142-148</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>In the present study, we have investigated the analgesic effect of the aqueous extract of the root of
Glycine tomentella (AGT) using models of acetic acid-induced writhing response and formalin test, the anti-inflammatory effect of AGT using model of λ-carrageenan-induced paw edema. In order to investigate the anti-inflammatory mechanism of AGT, we have detected the activities of glutathione peroxidase (GPx) and glutathione reductase (GRx) in the liver and the levels of malondialdehyde (MDA) and NO in the edema paw.
In the analgesic test, AGT (0.5 and 1.0
g/kg) decreased the acetic acid-induced writhing response and the licking time on the late phase in the formalin test. In the anti-inflammatory test, AGT (0.5 and 1.0
g/kg) decreased the paw edema at the third, fourth, fifth and sixth hour after λ-carrageenan administration, and increased the activities of SOD, GPx and GRx in the liver tissue and decreased the MDA level in the edema paw at the third hour after λ-carrageenan injection. However, AGT could not affect the NO level which induced by λ-carrageenan.
These results suggested that AGT possessed analgesic and anti-inflammatory effects. The anti-inflammatory mechanism of AGT might be related to the decrease in the level of MDA in the edema paw
via increasing the activities of SOD, GPx and GRx in the liver.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>17616291</pmid><doi>10.1016/j.jep.2007.05.024</doi><tpages>7</tpages></addata></record> |
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| subjects | Acetic Acid Analgesia analgesic effect Analgesics - administration & dosage Analgesics - pharmacology Animals Anti-inflammation anti-inflammatory activity Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacology bioassays Biological and medical sciences Carrageenan chemical constituents of plants Edema - drug therapy Fabaceae - chemistry Formaldehyde General pharmacology Glutathione Peroxidase - drug effects Glutathione Peroxidase - metabolism Glutathione Reductase - drug effects Glutathione Reductase - metabolism Glycine tomentella Inflammation - drug therapy Liver - drug effects Liver - metabolism Male Malondialdehyde - metabolism MDA Medical sciences medicinal plants medicinal properties Mice Mice, Inbred ICR Nitric Oxide - metabolism Pain - drug therapy Pain Measurement Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Roots roots SOD Superoxide Dismutase - drug effects Superoxide Dismutase - metabolism Time Factors |
| title | Analgesic and anti-inflammatory activities of aqueous extract from Glycine tomentella root in mice |
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