Prognostic Value of Admission Myeloperoxidase Levels in Patients With ST-Segment Elevation Myocardial Infarction and Cardiogenic Shock
Inflammation plays a critical role in acute myocardial infarction. One inflammatory marker is myeloperoxidase (MPO). Its role as a predictor of in-hospital death in patients with ST-segment elevation myocardial infarction (STEMI) presenting with cardiogenic shock (CS) is unclear. Therefore, the aim...
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| Veröffentlicht in: | The American journal of cardiology 2008-06, Vol.101 (11), p.1537-1540 |
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| container_title | The American journal of cardiology |
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| creator | Dominguez-Rodriguez, Alberto, MD, PhD Samimi-Fard, Sima, MD Abreu-Gonzalez, Pedro, PhD Garcia-Gonzalez, Martin J., MD, PhD Kaski, Juan Carlos, MD, DSc |
| description | Inflammation plays a critical role in acute myocardial infarction. One inflammatory marker is myeloperoxidase (MPO). Its role as a predictor of in-hospital death in patients with ST-segment elevation myocardial infarction (STEMI) presenting with cardiogenic shock (CS) is unclear. Therefore, the aim of this study was to investigate the role of MPO as a predictor of in-hospital death in patients with STEMIs presenting with CS and treated with primary percutaneous coronary intervention. In 38 consecutive patients with CS complicating STEMIs who were treated with primary percutaneous coronary intervention, serum MPO levels were measured at coronary care unit admission using a commercially available enzyme-linked immunosorbent assay. The primary study end point was in-hospital cardiac death. Among the 38 patients included in the study, 20 died during their coronary care unit stays, whereas 18 survived. Compared with patients who survived, patients who died showed, at coronary care unit admission, higher serum MPO levels (81 ± 28 vs 56 ± 23 ng/ml, p |
| doi_str_mv | 10.1016/j.amjcard.2008.02.032 |
| format | Article |
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One inflammatory marker is myeloperoxidase (MPO). Its role as a predictor of in-hospital death in patients with ST-segment elevation myocardial infarction (STEMI) presenting with cardiogenic shock (CS) is unclear. Therefore, the aim of this study was to investigate the role of MPO as a predictor of in-hospital death in patients with STEMIs presenting with CS and treated with primary percutaneous coronary intervention. In 38 consecutive patients with CS complicating STEMIs who were treated with primary percutaneous coronary intervention, serum MPO levels were measured at coronary care unit admission using a commercially available enzyme-linked immunosorbent assay. The primary study end point was in-hospital cardiac death. Among the 38 patients included in the study, 20 died during their coronary care unit stays, whereas 18 survived. Compared with patients who survived, patients who died showed, at coronary care unit admission, higher serum MPO levels (81 ± 28 vs 56 ± 23 ng/ml, p <0.006). After controlling for different baseline clinical, laboratory, and angiographic variables, baseline serum MPO level was an independent predictor of in-hospital mortality on multivariate analysis (odds ratio 3.9, 95% confidence interval 1.8 to 7.5, p <0.001). In conclusion, admission MPO concentration is an independent predictor of in-hospital mortality in patients with STEMIs presenting with CS.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2008.02.032</identifier><identifier>PMID: 18489929</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Anesthesia. Intensive care medicine. Transfusions. 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One inflammatory marker is myeloperoxidase (MPO). Its role as a predictor of in-hospital death in patients with ST-segment elevation myocardial infarction (STEMI) presenting with cardiogenic shock (CS) is unclear. Therefore, the aim of this study was to investigate the role of MPO as a predictor of in-hospital death in patients with STEMIs presenting with CS and treated with primary percutaneous coronary intervention. In 38 consecutive patients with CS complicating STEMIs who were treated with primary percutaneous coronary intervention, serum MPO levels were measured at coronary care unit admission using a commercially available enzyme-linked immunosorbent assay. The primary study end point was in-hospital cardiac death. Among the 38 patients included in the study, 20 died during their coronary care unit stays, whereas 18 survived. Compared with patients who survived, patients who died showed, at coronary care unit admission, higher serum MPO levels (81 ± 28 vs 56 ± 23 ng/ml, p <0.006). After controlling for different baseline clinical, laboratory, and angiographic variables, baseline serum MPO level was an independent predictor of in-hospital mortality on multivariate analysis (odds ratio 3.9, 95% confidence interval 1.8 to 7.5, p <0.001). In conclusion, admission MPO concentration is an independent predictor of in-hospital mortality in patients with STEMIs presenting with CS.</description><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Confidence Intervals</subject><subject>Coronary Care Units</subject><subject>Coronary heart disease</subject><subject>Diagnostic Tests, Routine - methods</subject><subject>Electrocardiography</subject><subject>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Hospital Mortality - trends</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical sciences</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - enzymology</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Myocarditis. Cardiomyopathies</subject><subject>Odds Ratio</subject><subject>Patients</subject><subject>Peroxidase - blood</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Shock, Cardiogenic - enzymology</subject><subject>Shock, Cardiogenic - etiology</subject><subject>Shock, Cardiogenic - physiopathology</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFktFu0zAUhiMEYqXwCCALCe4Sjh0nsW-YpmrApCImdcCl5TonnTs3LnZa0RfguXHWaki74cr28f8f_0efs-w1hYICrT-sC71ZGx3aggGIAlgBJXuSTahoZE4lLZ9mEwBguaRcnmUvYlynI6VV_Tw7o4ILKZmcZH-ug1_1Pg7WkB_a7ZD4jly0Gxuj9T35ekDntxj8b9vqiGSOe3SR2J5c68FiP0Ty0w63ZHGTL3C1SQVy6XCf7u7NfgxotSNXfaeDua_qviWzsexX2KdXF7fe3L3MnnXaRXx1WqfZ90-XN7Mv-fzb56vZxTw3vKmGfFnLRrBWLLlkXS2hNgKWshZloxlU1GgDddvVHTeNMDUsGZeCgzCGcV4j0HKavT_23Qb_a4dxUGlSg87pHv0uqgaaqiopT8K3j4Rrvwt9yqZYCWXDmRRJVB1FJvgYA3ZqG-xGh4OioEZKaq1OlNRISQFTiVLyvTk13y032P5znbAkwbuTQEejXRd0b2x80DEopRhjTLPzoy5Bwb3FoKJJVAy2NqAZVOvtf6N8fNTBOJuwaHeHB4wPQ1MVk0Etxi81_igQaVNyUf4F_wfHzA</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>Dominguez-Rodriguez, Alberto, MD, PhD</creator><creator>Samimi-Fard, Sima, MD</creator><creator>Abreu-Gonzalez, Pedro, PhD</creator><creator>Garcia-Gonzalez, Martin J., MD, PhD</creator><creator>Kaski, Juan Carlos, MD, DSc</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20080601</creationdate><title>Prognostic Value of Admission Myeloperoxidase Levels in Patients With ST-Segment Elevation Myocardial Infarction and Cardiogenic Shock</title><author>Dominguez-Rodriguez, Alberto, MD, PhD ; Samimi-Fard, Sima, MD ; Abreu-Gonzalez, Pedro, PhD ; Garcia-Gonzalez, Martin J., MD, PhD ; Kaski, Juan Carlos, MD, DSc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-b69782d8b492f6906c80b96837a2051cac06df6f4c78c60b2498408cc2446e013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Cardiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Confidence Intervals</topic><topic>Coronary Care Units</topic><topic>Coronary heart disease</topic><topic>Diagnostic Tests, Routine - methods</topic><topic>Electrocardiography</topic><topic>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Hospital Mortality - trends</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>Myocardial Infarction - complications</topic><topic>Myocardial Infarction - enzymology</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Myocarditis. Cardiomyopathies</topic><topic>Odds Ratio</topic><topic>Patients</topic><topic>Peroxidase - blood</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Shock, Cardiogenic - enzymology</topic><topic>Shock, Cardiogenic - etiology</topic><topic>Shock, Cardiogenic - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dominguez-Rodriguez, Alberto, MD, PhD</creatorcontrib><creatorcontrib>Samimi-Fard, Sima, MD</creatorcontrib><creatorcontrib>Abreu-Gonzalez, Pedro, PhD</creatorcontrib><creatorcontrib>Garcia-Gonzalez, Martin J., MD, PhD</creatorcontrib><creatorcontrib>Kaski, Juan Carlos, MD, DSc</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dominguez-Rodriguez, Alberto, MD, PhD</au><au>Samimi-Fard, Sima, MD</au><au>Abreu-Gonzalez, Pedro, PhD</au><au>Garcia-Gonzalez, Martin J., MD, PhD</au><au>Kaski, Juan Carlos, MD, DSc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Value of Admission Myeloperoxidase Levels in Patients With ST-Segment Elevation Myocardial Infarction and Cardiogenic Shock</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>101</volume><issue>11</issue><spage>1537</spage><epage>1540</epage><pages>1537-1540</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>Inflammation plays a critical role in acute myocardial infarction. One inflammatory marker is myeloperoxidase (MPO). Its role as a predictor of in-hospital death in patients with ST-segment elevation myocardial infarction (STEMI) presenting with cardiogenic shock (CS) is unclear. Therefore, the aim of this study was to investigate the role of MPO as a predictor of in-hospital death in patients with STEMIs presenting with CS and treated with primary percutaneous coronary intervention. In 38 consecutive patients with CS complicating STEMIs who were treated with primary percutaneous coronary intervention, serum MPO levels were measured at coronary care unit admission using a commercially available enzyme-linked immunosorbent assay. The primary study end point was in-hospital cardiac death. Among the 38 patients included in the study, 20 died during their coronary care unit stays, whereas 18 survived. Compared with patients who survived, patients who died showed, at coronary care unit admission, higher serum MPO levels (81 ± 28 vs 56 ± 23 ng/ml, p <0.006). After controlling for different baseline clinical, laboratory, and angiographic variables, baseline serum MPO level was an independent predictor of in-hospital mortality on multivariate analysis (odds ratio 3.9, 95% confidence interval 1.8 to 7.5, p <0.001). In conclusion, admission MPO concentration is an independent predictor of in-hospital mortality in patients with STEMIs presenting with CS.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>18489929</pmid><doi>10.1016/j.amjcard.2008.02.032</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Biomarkers - blood Cardiology Cardiology. Vascular system Cardiovascular Confidence Intervals Coronary Care Units Coronary heart disease Diagnostic Tests, Routine - methods Electrocardiography Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Enzyme-Linked Immunosorbent Assay Female Heart Heart attacks Hospital Mortality - trends Humans Intensive care medicine Male Medical prognosis Medical sciences Myocardial Infarction - complications Myocardial Infarction - enzymology Myocardial Infarction - physiopathology Myocarditis. Cardiomyopathies Odds Ratio Patients Peroxidase - blood Prognosis Risk Factors Severity of Illness Index Shock, Cardiogenic - enzymology Shock, Cardiogenic - etiology Shock, Cardiogenic - physiopathology |
| title | Prognostic Value of Admission Myeloperoxidase Levels in Patients With ST-Segment Elevation Myocardial Infarction and Cardiogenic Shock |
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