Adenovirus 5 and 35 vectors expressing Plasmodium falciparum circumsporozoite surface protein elicit potent antigen-specific cellular IFN-γ and antibody responses in mice

Abstract Falciparum malaria vaccine candidates have been developed using recombinant, replication-deficient serotype 5 and 35 adenoviruses (Ad5, Ad35) encoding the Plasmodium falciparum circumsporozoite surface protein (CSP) (Ad5.CS, Ad35.CS) (Crucell Holland BV, Leiden, The Netherlands). To evaluat...

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Veröffentlicht in:	Vaccine 2008-06, Vol.26 (23), p.2818-2823
Hauptverfasser:	Shott, Joseph P, McGrath, Shannon M, Pau, Maria Grazia, Custers, Jerome H.V, Ophorst, Olga, Demoitié, Marie-Ange, Dubois, Marie-Claude, Komisar, Jack, Cobb, Michelle, Kester, Kent E, Dubois, Patrice, Cohen, Joe, Goudsmit, Jaap, Heppner, D. Gray, Stewart, V. Ann
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus 35 Adenovirus 5 Allergy and Immunology Animals Antibodies, Protozoan - analysis Antibodies, Protozoan - biosynthesis Antigens, Protozoan - genetics Antigens, Protozoan - immunology Applied microbiology AS01B Biological and medical sciences Circumsporozoite Enzyme-Linked Immunosorbent Assay Falciparum Fundamental and applied biological sciences. Psychology Genetic Vectors Human protozoal diseases Immunization Schedule Immunization, Secondary Infectious diseases Interferon-gamma - biosynthesis Life cycle. Host-agent relationship. Pathogenesis Malaria Malaria Vaccines - immunology Male Medical sciences Mice Mice, Inbred BALB C Microbiology Miscellaneous Parasitic diseases Plasmodium falciparum - genetics Plasmodium falciparum - metabolism Protozoa Protozoal diseases Sporozoites - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Virology
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