Evidence for major pleiotropic effects on bone size variation from a principal component analysis of 451 Caucasian families

Aim： To identify pleiotropic quantitative trait loci （QTL） influencing bone size （BS） at different skeletal sites in Caucasians. Methods： In a sample containing 3899 Caucasians from 451 pedigrees, 410 microsatellite markers spaced ～8.9 cM apart across the human genome were genotyped. Phenotypical an...

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Veröffentlicht in:	Acta pharmacologica Sinica 2008-06, Vol.29 (6), p.745-751
Hauptverfasser:	Tan, Li-jun, Liu, Yao-zhong, Xiao, Peng, Yang, Fang, Tang, Zi-hui, Liu, Peng-yuan, Recker, Robert R, Deng, Hong-wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomedical and Life Sciences Biomedicine Bone and Bones - anatomy & histology European Continental Ancestry Group Female Genetic Linkage - genetics Genotype Humans Immunology Internal Medicine Male Medical Microbiology Microsatellite Repeats Middle Aged original-article Pharmacology/Toxicology Principal Component Analysis QTL Quantitative Trait Loci Reverse Transcriptase Polymerase Chain Reaction United States Vaccine 基因组连接骨头尺寸高加索人
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