Osmotic stress induces terminal differentiation in cultured normal human epidermal keratinocytes

The signals for epidermal differentiation and barrier formation are largely unknown. One possible signal is dehydration or osmotic stress. To test this hypothesis, we investigated the effects of osmotic stress on markers of differentiation of normal human keratinocytes in culture. Hyperosmotic stres...

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Veröffentlicht in:	In vitro cellular & developmental biology. Animal 2008-05, Vol.44 (5), p.135-139
Hauptverfasser:	Mammone, Thomas, Ingrassia, Michael, Goyarts, Earl
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Biomedical and Life Sciences Calcium Cell Biology Cell Culture Cell Differentiation Cells, Cultured Cultured cells Dehydration Developmental Biology Differentiation Epidermis Epidermis - cytology Gels Gene Expression Regulation Humans Keratinocytes Keratinocytes - cytology Keratins Keratins - genetics Keratins - metabolism Life Sciences Messenger RNA Osmotic Pressure Osmotic stress Protein Precursors - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Slavic culture Stem Cells Transglutaminases - genetics Transglutaminases - metabolism
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