Living in a phagolysosome; metabolism of Leishmania amastigotes
Leishmania amastigotes primarily proliferate within macrophages in the mammalian host. Genome-based metabolic reconstructions, combined with biochemical, reverse genetic and mRNA or protein profiling studies are providing new insights into the metabolism of this intracellular stage. We propose that...
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| Veröffentlicht in: | Trends in parasitology 2007-08, Vol.23 (8), p.368-375 |
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| container_title | Trends in parasitology |
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| creator | McConville, Malcolm J de Souza, David Saunders, Eleanor Likic, Vladimir A Naderer, Thomas |
| description | Leishmania amastigotes primarily proliferate within macrophages in the mammalian host. Genome-based metabolic reconstructions, combined with biochemical, reverse genetic and mRNA or protein profiling studies are providing new insights into the metabolism of this intracellular stage. We propose that the complex nutritional requirements of amastigotes have contributed to the tropism of these parasites for the amino acid-rich phagolysosome of macrophages. Amastigote metabolism in this compartment is robust because many metabolic mutants are capable of either growing normally or persisting long term in susceptible animals. New approaches for measuring amastigote metabolism in vivo are discussed. |
| doi_str_mv | 10.1016/j.pt.2007.06.009 |
| format | Article |
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| ispartof | Trends in parasitology, 2007-08, Vol.23 (8), p.368-375 |
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| subjects | Animals Biological and medical sciences Biological Transport Cell Division Gastroenterology and Hepatology Gene Expression Gene Expression Profiling Host-Parasite Interactions Human protozoal diseases Humans Infectious Disease Infectious diseases Leishmania Leishmania - cytology Leishmania - metabolism Leshmaniasis Macrophages - parasitology Medical sciences Membrane Transport Proteins - metabolism Parasitic diseases Phagosomes - metabolism Protozoal diseases |
| title | Living in a phagolysosome; metabolism of Leishmania amastigotes |
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