Using biorelevant dissolution to obtain IVIVC of solid dosage forms containing a poorly-soluble model compound

The usefulness of selected biorelevant dissolution media (BDM) to predict in vivo drug absorption was studied. Dissolution profiles of solid formulations of a poorly soluble model compound were compared in BDM simulating fasted and two levels of fed state. A non-physiologically relevant medium conta...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2008-06, Vol.69 (2), p.648-657
Hauptverfasser:	Lue, Bena-Marie, Nielsen, Flemming Seier, Magnussen, Thomas, Schou, Hanne Mette, Kristensen, Kim, Jacobsen, Lene Orup, Müllertz, Anette
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Infective Agents, Local - administration & dosage Anti-Infective Agents, Local - chemistry Anti-Infective Agents, Local - pharmacokinetics Biological and medical sciences Biorelevant media Cetrimonium Compounds - administration & dosage Cetrimonium Compounds - chemistry Cetrimonium Compounds - pharmacokinetics Chemical Phenomena Chemistry, Pharmaceutical Chemistry, Physical Chromatography, High Pressure Liquid Dissolution Dogs Dosage Forms Excipients Female General pharmacology In vivo–in vitro correlation (IVIVC) Kinetics Male Medical sciences Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Poorly soluble Solubility Solvents
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