bacterial ecto-triphosphate diphosphohydrolase similar to human CD39 is essential for intracellular multiplication of Legionella pneumophila

As part of its pathogenesis, Legionella pneumophila persists within human alveolar macrophages in non-acidified organelles that do not mature into phagolysosomes. Two L. pneumophila genes, lpg0971 and lpg1905, are predicted to encode ecto-nucleoside triphosphate diphosphohydrolases (ecto-NTPDases) t...

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Veröffentlicht in:	Cellular microbiology 2007-08, Vol.9 (8), p.1922-1935
Hauptverfasser:	Sansom, Fiona M, Newton, Hayley J, Crikis, Sandra, Cianciotto, Nicholas P, Cowan, Peter J, d'Apice, Anthony J.F, Hartland, Elizabeth L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - genetics Adenosine Triphosphatases - physiology Amino Acid Sequence Amoeba Animals Antigens, CD - genetics Apyrase - genetics Bacteria Bacterial Proteins - genetics Bacterial Proteins - pharmacology Bacterial Proteins - physiology Biological Transport, Active Cell Line Computational Biology Epithelial Cells - metabolism Epithelial Cells - microbiology Hartmannella - microbiology Hartmannella vermiformis Humans In Vitro Techniques Legionella pneumophila Legionella pneumophila - enzymology Legionella pneumophila - isolation & purification Legionella pneumophila - physiology Molecular Sequence Data Monocytes - metabolism Monocytes - microbiology Mutation Platelet Aggregation Pyrophosphatases - genetics Pyrophosphatases - pharmacology Pyrophosphatases - physiology Recombinant Proteins - pharmacology Toxoplasma gondii Trichomonas vaginalis Trypanosoma cruzi Virulence Factors - genetics Virulence Factors - isolation & purification Virulence Factors - physiology
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