Induction of covalent binding antibodies

Covalent interactions between antibody combining site residues and substrates have been implicated in the catalytic activity of abzymes elicited by design or occurring naturally in autoimmune disease. In this study, the potential for covalent binding by antibodies (Abs) was investigated by the induc...

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Veröffentlicht in:	Immunology Letters 2006-02, Vol.103 (1), p.51-57
Hauptverfasser:	Armentano, Francesca, Knight, Thomas, Makker, Sudesh, Tramontano, Alfonso
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Catalytic - chemistry Antibodies, Catalytic - immunology Antibodies, Catalytic - metabolism Antibody catalysis Antigen-Antibody Reactions Covalent binding Esters - chemistry Female Immunization Immunoassay Mice Molecular Structure Nucleophilic residue Organophosphonates - chemistry Protein Binding Serine protease
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