eNOS Function and Dysfunction in the Penis
Endothelial nitric oxide (NO) synthase (eNOS) has an indispensable role in the erectile response. In the penis, eNOS activity and endothelial NO bioavailability are regulated by multiple post-translatlonal molecular mechanisms, such as eNOS phosphorylation, eNOS interaction with regulatory proteins...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 2006-02, Vol.231 (2), p.154-165 |
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| creator | Musicki, Biljana Burnett, Arthur L. |
| description | Endothelial nitric oxide (NO) synthase (eNOS) has an indispensable role in the erectile response. In the penis, eNOS activity and endothelial NO bioavailability are regulated by multiple post-translatlonal molecular mechanisms, such as eNOS phosphorylation, eNOS interaction with regulatory proteins and contractile pathways, and actions of reactive oxygen species (ROS). These mechanisms regulate eNOS-mediated responses under physiologic circumstances and provide various mechanisms whereby endothelial NO availability may be altered in states of vasculogenlc erectile dysfunction (ED), in view of the recent advances in the field of eNOS function in the penis and its role in penile erection, the emphasis in this review is placed on the mechanisms regulating eNOS activity and its interaction with the RhoA/Rho-kinase pathway in the physiology of penile erection and the pathophysiology of ED. |
| doi_str_mv | 10.1177/153537020623100205 |
| format | Article |
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These mechanisms regulate eNOS-mediated responses under physiologic circumstances and provide various mechanisms whereby endothelial NO availability may be altered in states of vasculogenlc erectile dysfunction (ED), in view of the recent advances in the field of eNOS function in the penis and its role in penile erection, the emphasis in this review is placed on the mechanisms regulating eNOS activity and its interaction with the RhoA/Rho-kinase pathway in the physiology of penile erection and the pathophysiology of ED.</description><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.1177/153537020623100205</identifier><identifier>PMID: 16446491</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aging - physiology ; Diabetes Mellitus - metabolism ; Humans ; Hypercholesterolemia - metabolism ; Hypertension - metabolism ; Intracellular Signaling Peptides and Proteins ; Male ; Nitric Oxide - metabolism ; Nitric Oxide Synthase Type III - metabolism ; Penile Erection - physiology ; Penis - enzymology ; Protein-Serine-Threonine Kinases - metabolism ; Receptors, G-Protein-Coupled - metabolism ; rho-Associated Kinases ; rhoA GTP-Binding Protein - metabolism ; Signal Transduction - physiology</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 2006-02, Vol.231 (2), p.154-165</ispartof><rights>2006 by the Society for Experimental Biology and Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-52499ce7539a9e1a774cc8c73555e6a861bab68a035fafd889d8594aa6b4996a3</citedby><cites>FETCH-LOGICAL-c407t-52499ce7539a9e1a774cc8c73555e6a861bab68a035fafd889d8594aa6b4996a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16446491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Musicki, Biljana</creatorcontrib><creatorcontrib>Burnett, Arthur L.</creatorcontrib><title>eNOS Function and Dysfunction in the Penis</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Exp Biol Med (Maywood)</addtitle><description>Endothelial nitric oxide (NO) synthase (eNOS) has an indispensable role in the erectile response. In the penis, eNOS activity and endothelial NO bioavailability are regulated by multiple post-translatlonal molecular mechanisms, such as eNOS phosphorylation, eNOS interaction with regulatory proteins and contractile pathways, and actions of reactive oxygen species (ROS). These mechanisms regulate eNOS-mediated responses under physiologic circumstances and provide various mechanisms whereby endothelial NO availability may be altered in states of vasculogenlc erectile dysfunction (ED), in view of the recent advances in the field of eNOS function in the penis and its role in penile erection, the emphasis in this review is placed on the mechanisms regulating eNOS activity and its interaction with the RhoA/Rho-kinase pathway in the physiology of penile erection and the pathophysiology of ED.</description><subject>Aging - physiology</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Humans</subject><subject>Hypercholesterolemia - metabolism</subject><subject>Hypertension - metabolism</subject><subject>Intracellular Signaling Peptides and Proteins</subject><subject>Male</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitric Oxide Synthase Type III - metabolism</subject><subject>Penile Erection - physiology</subject><subject>Penis - enzymology</subject><subject>Protein-Serine-Threonine Kinases - metabolism</subject><subject>Receptors, G-Protein-Coupled - metabolism</subject><subject>rho-Associated Kinases</subject><subject>rhoA GTP-Binding Protein - metabolism</subject><subject>Signal Transduction - physiology</subject><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9Lw0AQxRdRbK1-AQ-Skwchdjf7_yjVqlCsoJ6XyWajKcmmZpNDv71b2uJB8PRmht97MA-hS4JvCZFySjjlVOIMi4wSHJUfofH2mFKh9fFhjsQInYWwwphwmYlTNCKCMcE0GaMb97J8S-aDt33V-gR8kdxvQnnYK5_0Xy55db4K5-ikhDq4i71O0Mf84X32lC6Wj8-zu0VqGZZ9yjOmtXWSUw3aEZCSWauspJxzJ0AJkkMuFGDKSygLpXShuGYAIo9GAXSCrne56679HlzoTVMF6-oavGuHYCSWTChGI5jtQNu1IXSuNOuuaqDbGILNtiHzt6FoutqnD3njil_LvpIITHdAgE9nVu3Q-fjtf5E_i69roA</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>Musicki, Biljana</creator><creator>Burnett, Arthur L.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060201</creationdate><title>eNOS Function and Dysfunction in the Penis</title><author>Musicki, Biljana ; Burnett, Arthur L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-52499ce7539a9e1a774cc8c73555e6a861bab68a035fafd889d8594aa6b4996a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aging - physiology</topic><topic>Diabetes Mellitus - metabolism</topic><topic>Humans</topic><topic>Hypercholesterolemia - metabolism</topic><topic>Hypertension - metabolism</topic><topic>Intracellular Signaling Peptides and Proteins</topic><topic>Male</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitric Oxide Synthase Type III - metabolism</topic><topic>Penile Erection - physiology</topic><topic>Penis - enzymology</topic><topic>Protein-Serine-Threonine Kinases - metabolism</topic><topic>Receptors, G-Protein-Coupled - metabolism</topic><topic>rho-Associated Kinases</topic><topic>rhoA GTP-Binding Protein - metabolism</topic><topic>Signal Transduction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Musicki, Biljana</creatorcontrib><creatorcontrib>Burnett, Arthur L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Musicki, Biljana</au><au>Burnett, Arthur L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>eNOS Function and Dysfunction in the Penis</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Exp Biol Med (Maywood)</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>231</volume><issue>2</issue><spage>154</spage><epage>165</epage><pages>154-165</pages><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Endothelial nitric oxide (NO) synthase (eNOS) has an indispensable role in the erectile response. 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| ispartof | Experimental biology and medicine (Maywood, N.J.), 2006-02, Vol.231 (2), p.154-165 |
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| subjects | Aging - physiology Diabetes Mellitus - metabolism Humans Hypercholesterolemia - metabolism Hypertension - metabolism Intracellular Signaling Peptides and Proteins Male Nitric Oxide - metabolism Nitric Oxide Synthase Type III - metabolism Penile Erection - physiology Penis - enzymology Protein-Serine-Threonine Kinases - metabolism Receptors, G-Protein-Coupled - metabolism rho-Associated Kinases rhoA GTP-Binding Protein - metabolism Signal Transduction - physiology |
| title | eNOS Function and Dysfunction in the Penis |
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