Interaction of Imatinib with Human Organic Ion Carriers

Purpose: The activity of imatinib in leukemia has recently been linked with expression of the organic cation transporter 1 (OCT1) gene SLC22A1 . Here, we characterized the contribution of solute carriers to imatinib transport in an effort to further understand mechanisms involved in the intracellula...

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Veröffentlicht in:	Clinical cancer research 2008-05, Vol.14 (10), p.3141-3148
Hauptverfasser:	Hu, Shuiying, Franke, Ryan M, Filipski, Kelly K, Hu, Chaoxin, Orwick, Shelley J, de Bruijn, Ernst A, Burger, Herman, Baker, Sharyn D, Sparreboom, Alex
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - metabolism Benzamides Cell Line, Tumor Drug Resistance, Neoplasm - genetics Gastrointestinal Stromal Tumors - drug therapy Gastrointestinal Stromal Tumors - genetics Gene Expression Humans imatinib Imatinib Mesylate Organic Cation Transporter 1 - genetics Organic Cation Transporter 1 - metabolism pharmacogenetics Piperazines - metabolism Polymerase Chain Reaction Pyrimidines - metabolism solute carriers Xenopus laevis
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