Interaction of huntingtin fragments with brain membranes – clues to early dysfunction in Huntington's disease

Huntingtin is a large, multi‐domain protein of unknown function in the brain. An abnormally elongated polyglutamine stretch in its N‐terminus causes Huntington's disease (HD), a progressive neurodegenerative disorder. Huntingtin has been proposed to play a functional role in membrane traffickin...

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Veröffentlicht in:	Journal of neurochemistry 2006-02, Vol.96 (3), p.870-884
Hauptverfasser:	Suopanki, Jaana, Götz, Claudia, Lutsch, Gudrun, Schiller, Jürgen, Harjes, Phoebe, Herrmann, Andreas, Wanker, Erich E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Biological and medical sciences Blotting, Western - methods Brain Brain - metabolism Brain - pathology Brain Chemistry Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Disease Models, Animal fibrillogenesis Fluoresceins - metabolism Fluorescent Antibody Technique - methods Humans huntingtin Huntington Disease - genetics Huntington Disease - metabolism Huntington Disease - pathology Immunoblotting - methods Medical sciences Membranes Mice Mice, Transgenic Microscopy, Electron, Transmission - methods Nerve Tissue Proteins - metabolism Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Neurons oligomers Phospholipids - metabolism Phosphoric Monoester Hydrolases - metabolism postsynaptic membranes Protein Binding - physiology Proteins Radiation Receptors, AMPA - metabolism Rodents Serotonin Plasma Membrane Transport Proteins - genetics Serotonin Plasma Membrane Transport Proteins - metabolism Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Synaptic Membranes - metabolism Synaptic Membranes - pathology Synaptic Vesicles - metabolism Synaptic Vesicles - pathology Time Factors
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