Predictors of course in obsessive-compulsive disorder: logistic regression versus Cox regression for recurrent events
Objective: Two methods for predicting remissions in obsessive–compulsive disorder (OCD) treatment are evaluated. Y‐BOCS measurements of 88 patients with a primary OCD (DSM‐III‐R) diagnosis were performed over a 16‐week treatment period, and during three follow‐ups. Method: Remission at any measure...
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| Veröffentlicht in: | Acta Psychiatrica Scandinavica 2007-09, Vol.116 (3), p.201-210 |
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| container_title | Acta Psychiatrica Scandinavica |
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| creator | Kempe, P. T. Van Oppen, P. De Haan, E. Twisk, J. W. R. Sluis, A. Smit, J. H. Van Dyck, R. Van Balkom, A. J. L. M. |
| description | Objective: Two methods for predicting remissions in obsessive–compulsive disorder (OCD) treatment are evaluated. Y‐BOCS measurements of 88 patients with a primary OCD (DSM‐III‐R) diagnosis were performed over a 16‐week treatment period, and during three follow‐ups.
Method: Remission at any measurement was defined as a Y‐BOCS score lower than thirteen combined with a reduction of seven points when compared with baseline. Logistic regression models were compared with a Cox regression for recurrent events model.
Results: Logistic regression yielded different models at different evaluation times. The recurrent events model remained stable when fewer measurements were used. Higher baseline levels of neuroticism and more severe OCD symptoms were associated with a lower chance of remission, early age of onset and more depressive symptoms with a higher chance.
Conclusion: Choice of outcome time affects logistic regression prediction models. Recurrent events analysis uses all information on remissions and relapses. Short‐ and long‐term predictors for OCD remission show overlap. |
| doi_str_mv | 10.1111/j.1600-0447.2007.00997.x |
| format | Article |
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Method: Remission at any measurement was defined as a Y‐BOCS score lower than thirteen combined with a reduction of seven points when compared with baseline. Logistic regression models were compared with a Cox regression for recurrent events model.
Results: Logistic regression yielded different models at different evaluation times. The recurrent events model remained stable when fewer measurements were used. Higher baseline levels of neuroticism and more severe OCD symptoms were associated with a lower chance of remission, early age of onset and more depressive symptoms with a higher chance.
Conclusion: Choice of outcome time affects logistic regression prediction models. Recurrent events analysis uses all information on remissions and relapses. Short‐ and long‐term predictors for OCD remission show overlap.</description><identifier>ISSN: 0001-690X</identifier><identifier>EISSN: 1600-0447</identifier><identifier>EISSN: 0065-1591</identifier><identifier>DOI: 10.1111/j.1600-0447.2007.00997.x</identifier><identifier>PMID: 17655562</identifier><identifier>CODEN: APYSA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult and adolescent clinical studies ; Anti-Anxiety Agents - therapeutic use ; Anxiety disorders. Neuroses ; Behavior Therapy ; Biological and medical sciences ; Cognitive Therapy ; Combined Modality Therapy ; Comparative analysis ; Depression - diagnosis ; Depression - psychology ; Depression - therapy ; Desensitization, Psychologic ; Fluvoxamine - therapeutic use ; Follow-Up Studies ; forecasting ; Humans ; Logistic Models ; Medical sciences ; Neuroses ; Neurotic Disorders - diagnosis ; Neurotic Disorders - psychology ; Neurotic Disorders - therapy ; obsessive-compulsive disorder ; Obsessive-Compulsive Disorder - diagnosis ; Obsessive-Compulsive Disorder - psychology ; Obsessive-Compulsive Disorder - therapy ; Obsessive-compulsive disorders ; Outcome and Process Assessment (Health Care) - statistics & numerical data ; Personality Inventory - statistics & numerical data ; Proportional Hazards Models ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychometrics ; Psychopathology. Psychiatry ; Randomized Controlled Trials as Topic ; Recurrence ; Regression analysis ; remission induction ; treatment outcome</subject><ispartof>Acta Psychiatrica Scandinavica, 2007-09, Vol.116 (3), p.201-210</ispartof><rights>2007 INIST-CNRS</rights><rights>2007 The Authors Journal Compilation 2007 Blackwell Munksgaard</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4937-45925b1d0d43a750b5b3fb2ef695f8538e49b142192cb6ce9abe19f0043908f23</citedby><cites>FETCH-LOGICAL-c4937-45925b1d0d43a750b5b3fb2ef695f8538e49b142192cb6ce9abe19f0043908f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0447.2007.00997.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0447.2007.00997.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18949336$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17655562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kempe, P. T.</creatorcontrib><creatorcontrib>Van Oppen, P.</creatorcontrib><creatorcontrib>De Haan, E.</creatorcontrib><creatorcontrib>Twisk, J. W. R.</creatorcontrib><creatorcontrib>Sluis, A.</creatorcontrib><creatorcontrib>Smit, J. H.</creatorcontrib><creatorcontrib>Van Dyck, R.</creatorcontrib><creatorcontrib>Van Balkom, A. J. L. M.</creatorcontrib><title>Predictors of course in obsessive-compulsive disorder: logistic regression versus Cox regression for recurrent events</title><title>Acta Psychiatrica Scandinavica</title><addtitle>Acta Psychiatr Scand</addtitle><description>Objective: Two methods for predicting remissions in obsessive–compulsive disorder (OCD) treatment are evaluated. Y‐BOCS measurements of 88 patients with a primary OCD (DSM‐III‐R) diagnosis were performed over a 16‐week treatment period, and during three follow‐ups.
Method: Remission at any measurement was defined as a Y‐BOCS score lower than thirteen combined with a reduction of seven points when compared with baseline. Logistic regression models were compared with a Cox regression for recurrent events model.
Results: Logistic regression yielded different models at different evaluation times. The recurrent events model remained stable when fewer measurements were used. Higher baseline levels of neuroticism and more severe OCD symptoms were associated with a lower chance of remission, early age of onset and more depressive symptoms with a higher chance.
Conclusion: Choice of outcome time affects logistic regression prediction models. Recurrent events analysis uses all information on remissions and relapses. Short‐ and long‐term predictors for OCD remission show overlap.</description><subject>Adult and adolescent clinical studies</subject><subject>Anti-Anxiety Agents - therapeutic use</subject><subject>Anxiety disorders. Neuroses</subject><subject>Behavior Therapy</subject><subject>Biological and medical sciences</subject><subject>Cognitive Therapy</subject><subject>Combined Modality Therapy</subject><subject>Comparative analysis</subject><subject>Depression - diagnosis</subject><subject>Depression - psychology</subject><subject>Depression - therapy</subject><subject>Desensitization, Psychologic</subject><subject>Fluvoxamine - therapeutic use</subject><subject>Follow-Up Studies</subject><subject>forecasting</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Medical sciences</subject><subject>Neuroses</subject><subject>Neurotic Disorders - diagnosis</subject><subject>Neurotic Disorders - psychology</subject><subject>Neurotic Disorders - therapy</subject><subject>obsessive-compulsive disorder</subject><subject>Obsessive-Compulsive Disorder - diagnosis</subject><subject>Obsessive-Compulsive Disorder - psychology</subject><subject>Obsessive-Compulsive Disorder - therapy</subject><subject>Obsessive-compulsive disorders</subject><subject>Outcome and Process Assessment (Health Care) - statistics & numerical data</subject><subject>Personality Inventory - statistics & numerical data</subject><subject>Proportional Hazards Models</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychometrics</subject><subject>Psychopathology. Psychiatry</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Recurrence</subject><subject>Regression analysis</subject><subject>remission induction</subject><subject>treatment outcome</subject><issn>0001-690X</issn><issn>1600-0447</issn><issn>0065-1591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkdtu1DAQhi0EokvhFZCFBHcJ48SHGImLKtByqKCcBHdW4kwqL9l4sTfL9u1x2FWLuAFf2DP294_G8xNCGeQsrafLnEmADDhXeQGgcgCtVb67RRbXD7fJAgBYJjV8OyL3YlymVDCo7pIjpqQQQhYLMl0E7Jzd-BCp76n1U4hI3Uh9GzFGt8XM-tV6GuaQdi760GF4Rgd_6eLGWRrwMsygH-kWQ5wirf3uz9veh5TaKQQcNxS3aY_3yZ2-GSI-OJzH5Mvpy8_1q-z8_dnr-uQ8s1yXKuNCF6JlHXS8bJSAVrRl3xbYSy36SpQVct0yXjBd2FZa1E2LTPcAvNRQ9UV5TJ7s666D_zFh3JiVixaHoRnRT9EoUFwUkv8TZFrxNGKdwEd_gcs0sjF9IjGiElyASFC1h2zwMQbszTq4VROuDAMzG2iWZvbJzD6Z2UDz20CzS9KHh_pTu8LuRnhwLAGPD0ATbTP0oRmtizdcpdPoSpm453vupxvw6r8bMCf1xacUJX221yebcXetb8J3I1WphPn67sy8qD--ffNBnhpR_gI1Zccu</recordid><startdate>200709</startdate><enddate>200709</enddate><creator>Kempe, P. T.</creator><creator>Van Oppen, P.</creator><creator>De Haan, E.</creator><creator>Twisk, J. W. R.</creator><creator>Sluis, A.</creator><creator>Smit, J. H.</creator><creator>Van Dyck, R.</creator><creator>Van Balkom, A. J. L. M.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200709</creationdate><title>Predictors of course in obsessive-compulsive disorder: logistic regression versus Cox regression for recurrent events</title><author>Kempe, P. T. ; Van Oppen, P. ; De Haan, E. ; Twisk, J. W. R. ; Sluis, A. ; Smit, J. H. ; Van Dyck, R. ; Van Balkom, A. J. L. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4937-45925b1d0d43a750b5b3fb2ef695f8538e49b142192cb6ce9abe19f0043908f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Anti-Anxiety Agents - therapeutic use</topic><topic>Anxiety disorders. Neuroses</topic><topic>Behavior Therapy</topic><topic>Biological and medical sciences</topic><topic>Cognitive Therapy</topic><topic>Combined Modality Therapy</topic><topic>Comparative analysis</topic><topic>Depression - diagnosis</topic><topic>Depression - psychology</topic><topic>Depression - therapy</topic><topic>Desensitization, Psychologic</topic><topic>Fluvoxamine - therapeutic use</topic><topic>Follow-Up Studies</topic><topic>forecasting</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Medical sciences</topic><topic>Neuroses</topic><topic>Neurotic Disorders - diagnosis</topic><topic>Neurotic Disorders - psychology</topic><topic>Neurotic Disorders - therapy</topic><topic>obsessive-compulsive disorder</topic><topic>Obsessive-Compulsive Disorder - diagnosis</topic><topic>Obsessive-Compulsive Disorder - psychology</topic><topic>Obsessive-Compulsive Disorder - therapy</topic><topic>Obsessive-compulsive disorders</topic><topic>Outcome and Process Assessment (Health Care) - statistics & numerical data</topic><topic>Personality Inventory - statistics & numerical data</topic><topic>Proportional Hazards Models</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychometrics</topic><topic>Psychopathology. Psychiatry</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Recurrence</topic><topic>Regression analysis</topic><topic>remission induction</topic><topic>treatment outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kempe, P. T.</creatorcontrib><creatorcontrib>Van Oppen, P.</creatorcontrib><creatorcontrib>De Haan, E.</creatorcontrib><creatorcontrib>Twisk, J. W. R.</creatorcontrib><creatorcontrib>Sluis, A.</creatorcontrib><creatorcontrib>Smit, J. H.</creatorcontrib><creatorcontrib>Van Dyck, R.</creatorcontrib><creatorcontrib>Van Balkom, A. J. L. M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Acta Psychiatrica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kempe, P. T.</au><au>Van Oppen, P.</au><au>De Haan, E.</au><au>Twisk, J. W. R.</au><au>Sluis, A.</au><au>Smit, J. H.</au><au>Van Dyck, R.</au><au>Van Balkom, A. J. L. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of course in obsessive-compulsive disorder: logistic regression versus Cox regression for recurrent events</atitle><jtitle>Acta Psychiatrica Scandinavica</jtitle><addtitle>Acta Psychiatr Scand</addtitle><date>2007-09</date><risdate>2007</risdate><volume>116</volume><issue>3</issue><spage>201</spage><epage>210</epage><pages>201-210</pages><issn>0001-690X</issn><eissn>1600-0447</eissn><eissn>0065-1591</eissn><coden>APYSA9</coden><abstract>Objective: Two methods for predicting remissions in obsessive–compulsive disorder (OCD) treatment are evaluated. Y‐BOCS measurements of 88 patients with a primary OCD (DSM‐III‐R) diagnosis were performed over a 16‐week treatment period, and during three follow‐ups.
Method: Remission at any measurement was defined as a Y‐BOCS score lower than thirteen combined with a reduction of seven points when compared with baseline. Logistic regression models were compared with a Cox regression for recurrent events model.
Results: Logistic regression yielded different models at different evaluation times. The recurrent events model remained stable when fewer measurements were used. Higher baseline levels of neuroticism and more severe OCD symptoms were associated with a lower chance of remission, early age of onset and more depressive symptoms with a higher chance.
Conclusion: Choice of outcome time affects logistic regression prediction models. Recurrent events analysis uses all information on remissions and relapses. Short‐ and long‐term predictors for OCD remission show overlap.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17655562</pmid><doi>10.1111/j.1600-0447.2007.00997.x</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult and adolescent clinical studies Anti-Anxiety Agents - therapeutic use Anxiety disorders. Neuroses Behavior Therapy Biological and medical sciences Cognitive Therapy Combined Modality Therapy Comparative analysis Depression - diagnosis Depression - psychology Depression - therapy Desensitization, Psychologic Fluvoxamine - therapeutic use Follow-Up Studies forecasting Humans Logistic Models Medical sciences Neuroses Neurotic Disorders - diagnosis Neurotic Disorders - psychology Neurotic Disorders - therapy obsessive-compulsive disorder Obsessive-Compulsive Disorder - diagnosis Obsessive-Compulsive Disorder - psychology Obsessive-Compulsive Disorder - therapy Obsessive-compulsive disorders Outcome and Process Assessment (Health Care) - statistics & numerical data Personality Inventory - statistics & numerical data Proportional Hazards Models Psychiatry Psychology. Psychoanalysis. Psychiatry Psychometrics Psychopathology. Psychiatry Randomized Controlled Trials as Topic Recurrence Regression analysis remission induction treatment outcome |
| title | Predictors of course in obsessive-compulsive disorder: logistic regression versus Cox regression for recurrent events |
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