The Effects of Fluticasone with or without Salmeterol on Systemic Biomarkers of Inflammation in Chronic Obstructive Pulmonary Disease

Small studies have suggested that inhaled corticosteroids can suppress systemic inflammation in chronic obstructive pulmonary disease (COPD). To determine the effect of inhaled corticosteroids with or without long-acting beta(2)-adrenergic agonist on systemic biomarkers of inflammation. We conducted...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2008-06, Vol.177 (11), p.1207-1214
Hauptverfasser:	Sin, Don D, Man, S. F. Paul, Marciniuk, Darcy D, Ford, Gordon, FitzGerald, Mark, Wong, Eric, York, Ernest, Mainra, Rajesh R, Ramesh, Warren, Melenka, Lyle S, Wilde, Eric, Cowie, Robert L, Williams, Dave, Gan, Wen Q, Rousseau, Roxanne, ABC (Advair, Biomarkers in COPD) Investigators
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Adrenergic beta-Agonists - administration & dosage Adrenergic receptors Aged Albuterol - administration & dosage Albuterol - analogs & derivatives Androstadienes - administration & dosage Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anti-Inflammatory Agents - administration & dosage Biological and medical sciences Biomarkers Biomarkers - metabolism C-Reactive Protein - metabolism Canada Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease, asthma Clinical outcomes Clinical trials Double-Blind Method Drug Combinations Female Fluticasone Fluticasone-Salmeterol Drug Combination Humans Inflammation Intensive care medicine Interleukin-6 - metabolism Male Medical sciences Middle Aged Mortality Pneumology Proteins Pulmonary Disease, Chronic Obstructive - drug therapy Pulmonary Disease, Chronic Obstructive - metabolism Pulmonary Disease, Chronic Obstructive - pathology Pulmonary Surfactant-Associated Protein D - metabolism Respiratory Function Tests Steroids Surfactants Treatment Outcome
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