Regulation of the Pro-apoptotic Scaffolding Protein POSH by Akt

POSH (Plenty of SH3 domains) binds to activated Rac and promotes apoptosis by acting as a scaffold to assemble a signal transduction pathway leading from Rac to JNK activation. Overexpression of POSH induces apoptosis in a variety of cell types, but apoptosis can be prevented by co-expressing the pr...

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Veröffentlicht in:	The Journal of biological chemistry 2007-07, Vol.282 (30), p.21987-21997
Hauptverfasser:	Lyons, Traci R., Thorburn, Jackie, Ryan, Philip W., Thorburn, Andrew, Anderson, Steven M., Kassenbrock, C. Kenneth
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - physiology Base Sequence Cell Line Cloning, Molecular Humans Kidney Molecular Sequence Data Proto-Oncogene Proteins c-akt - physiology Recombinant Fusion Proteins - metabolism Restriction Mapping Reverse Transcriptase Polymerase Chain Reaction Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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