Evaluation of pharyngeal shape and size using anatomical optical coherence tomography in individuals with and without obstructive sleep apnoea
Summary This study compared shape, size and length of the pharyngeal airway in individuals with and without obstructive sleep apnoea (OSA) using a novel endoscopic imaging technique, anatomical optical coherence tomography (aOCT). The study population comprised a preliminary study group of 20 OSA pa...
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| Veröffentlicht in: | Journal of sleep research 2008-06, Vol.17 (2), p.230-238 |
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| creator | WALSH, JENNIFER H. LEIGH, MATTHEW S. PADUCH, ALEXANDRE MADDISON, KATHLEEN J. PHILIPPE, DANIELLE L. ARMSTRONG, JULIAN J. SAMPSON, DAVID D. HILLMAN, DAVID R. EASTWOOD, PETER R. |
| description | Summary
This study compared shape, size and length of the pharyngeal airway in individuals with and without obstructive sleep apnoea (OSA) using a novel endoscopic imaging technique, anatomical optical coherence tomography (aOCT). The study population comprised a preliminary study group of 20 OSA patients and a subsequent controlled study group of 10 OSA patients and 10 body mass index (BMI)‐, gender‐ and age‐matched control subjects without OSA. All subjects were scanned using aOCT while awake, supine and breathing quietly. Measurements of airway cross‐sectional area (CSA) and anteroposterior (A‐P) and lateral diameters were obtained from the hypo‐, oro‐ and velopharyngeal regions. A‐P : lateral diameter ratios were calculated to provide an index of regional airway shape. In all subjects, pharyngeal CSA was lowest in the velopharynx. Patients with OSA had a smaller velopharyngeal CSA than controls (maximum CSA 91 ± 40 versus 153 ± 84 mm2; P |
| doi_str_mv | 10.1111/j.1365-2869.2008.00647.x |
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This study compared shape, size and length of the pharyngeal airway in individuals with and without obstructive sleep apnoea (OSA) using a novel endoscopic imaging technique, anatomical optical coherence tomography (aOCT). The study population comprised a preliminary study group of 20 OSA patients and a subsequent controlled study group of 10 OSA patients and 10 body mass index (BMI)‐, gender‐ and age‐matched control subjects without OSA. All subjects were scanned using aOCT while awake, supine and breathing quietly. Measurements of airway cross‐sectional area (CSA) and anteroposterior (A‐P) and lateral diameters were obtained from the hypo‐, oro‐ and velopharyngeal regions. A‐P : lateral diameter ratios were calculated to provide an index of regional airway shape. In all subjects, pharyngeal CSA was lowest in the velopharynx. Patients with OSA had a smaller velopharyngeal CSA than controls (maximum CSA 91 ± 40 versus 153 ± 84 mm2; P < 0.05) but comparable oro‐ (318 ± 80 versus 279 ± 129 mm2; P = 0.48) and hypopharyngeal CSA (250 ± 105 versus 303 ± 112 mm2; P = 0.36). In each pharyngeal region, the long axis of the airway was oriented in the lateral diameter. Airway shape was not different between the groups. Pharyngeal airway length was similar in both groups, although the OSA group had longer uvulae than the control group (16.8 ± 6.2 versus 11.2 ± 5.2 mm; P < 0.05). This study has shown that individuals with OSA have a smaller velopharyngeal CSA than BMI‐, gender‐ and age‐matched control volunteers, but comparable shape: a laterally oriented ellipse. These findings suggest that it is an abnormality in size rather than shape that is the more important anatomical predictor of OSA.</description><identifier>ISSN: 0962-1105</identifier><identifier>EISSN: 1365-2869</identifier><identifier>DOI: 10.1111/j.1365-2869.2008.00647.x</identifier><identifier>PMID: 18422508</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Airway Resistance - physiology ; Anthropometry ; Endoscopes ; Female ; Humans ; Hypopharynx - pathology ; Hypopharynx - physiopathology ; Image Processing, Computer-Assisted ; imaging ; Male ; Matched-Pair Analysis ; Middle Aged ; obstructive sleep apnoea ; optical coherence tomography ; Oropharynx - pathology ; Oropharynx - physiopathology ; pharyngeal ; pharynx ; Pharynx - pathology ; Pharynx - physiopathology ; Pulmonary Ventilation - physiology ; Reference Values ; Sensitivity and Specificity ; Sleep Apnea, Obstructive - pathology ; Sleep Apnea, Obstructive - physiopathology ; Tomography, Optical Coherence - instrumentation ; Velopharyngeal Insufficiency - pathology ; Velopharyngeal Insufficiency - physiopathology ; Wakefulness - physiology</subject><ispartof>Journal of sleep research, 2008-06, Vol.17 (2), p.230-238</ispartof><rights>2008 European Sleep Research Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3667-b477834c178c599bdbd5efc360d641f54b5dc1da4eff157ad868332c94d4b23b3</citedby><cites>FETCH-LOGICAL-c3667-b477834c178c599bdbd5efc360d641f54b5dc1da4eff157ad868332c94d4b23b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2869.2008.00647.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2869.2008.00647.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18422508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WALSH, JENNIFER H.</creatorcontrib><creatorcontrib>LEIGH, MATTHEW S.</creatorcontrib><creatorcontrib>PADUCH, ALEXANDRE</creatorcontrib><creatorcontrib>MADDISON, KATHLEEN J.</creatorcontrib><creatorcontrib>PHILIPPE, DANIELLE L.</creatorcontrib><creatorcontrib>ARMSTRONG, JULIAN J.</creatorcontrib><creatorcontrib>SAMPSON, DAVID D.</creatorcontrib><creatorcontrib>HILLMAN, DAVID R.</creatorcontrib><creatorcontrib>EASTWOOD, PETER R.</creatorcontrib><title>Evaluation of pharyngeal shape and size using anatomical optical coherence tomography in individuals with and without obstructive sleep apnoea</title><title>Journal of sleep research</title><addtitle>J Sleep Res</addtitle><description>Summary
This study compared shape, size and length of the pharyngeal airway in individuals with and without obstructive sleep apnoea (OSA) using a novel endoscopic imaging technique, anatomical optical coherence tomography (aOCT). The study population comprised a preliminary study group of 20 OSA patients and a subsequent controlled study group of 10 OSA patients and 10 body mass index (BMI)‐, gender‐ and age‐matched control subjects without OSA. All subjects were scanned using aOCT while awake, supine and breathing quietly. Measurements of airway cross‐sectional area (CSA) and anteroposterior (A‐P) and lateral diameters were obtained from the hypo‐, oro‐ and velopharyngeal regions. A‐P : lateral diameter ratios were calculated to provide an index of regional airway shape. In all subjects, pharyngeal CSA was lowest in the velopharynx. Patients with OSA had a smaller velopharyngeal CSA than controls (maximum CSA 91 ± 40 versus 153 ± 84 mm2; P < 0.05) but comparable oro‐ (318 ± 80 versus 279 ± 129 mm2; P = 0.48) and hypopharyngeal CSA (250 ± 105 versus 303 ± 112 mm2; P = 0.36). In each pharyngeal region, the long axis of the airway was oriented in the lateral diameter. Airway shape was not different between the groups. Pharyngeal airway length was similar in both groups, although the OSA group had longer uvulae than the control group (16.8 ± 6.2 versus 11.2 ± 5.2 mm; P < 0.05). This study has shown that individuals with OSA have a smaller velopharyngeal CSA than BMI‐, gender‐ and age‐matched control volunteers, but comparable shape: a laterally oriented ellipse. These findings suggest that it is an abnormality in size rather than shape that is the more important anatomical predictor of OSA.</description><subject>Adult</subject><subject>Aged</subject><subject>Airway Resistance - physiology</subject><subject>Anthropometry</subject><subject>Endoscopes</subject><subject>Female</subject><subject>Humans</subject><subject>Hypopharynx - pathology</subject><subject>Hypopharynx - physiopathology</subject><subject>Image Processing, Computer-Assisted</subject><subject>imaging</subject><subject>Male</subject><subject>Matched-Pair Analysis</subject><subject>Middle Aged</subject><subject>obstructive sleep apnoea</subject><subject>optical coherence tomography</subject><subject>Oropharynx - pathology</subject><subject>Oropharynx - physiopathology</subject><subject>pharyngeal</subject><subject>pharynx</subject><subject>Pharynx - pathology</subject><subject>Pharynx - physiopathology</subject><subject>Pulmonary Ventilation - physiology</subject><subject>Reference Values</subject><subject>Sensitivity and Specificity</subject><subject>Sleep Apnea, Obstructive - pathology</subject><subject>Sleep Apnea, Obstructive - physiopathology</subject><subject>Tomography, Optical Coherence - instrumentation</subject><subject>Velopharyngeal Insufficiency - pathology</subject><subject>Velopharyngeal Insufficiency - physiopathology</subject><subject>Wakefulness - physiology</subject><issn>0962-1105</issn><issn>1365-2869</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUctq3DAUFaWhmab9haJVd3YlS7Jk6KaEPFoChaRdC1m6HmvwWK5lTzL9iHxz5Jmh3UYI7hXnITgHIUxJTtP5sskpK0VWqLLKC0JUTkjJZf70Bq3-AW_RilRlkVFKxDl6H-OGECoFq96hc6p4UQiiVuj5ame62Uw-9Dg0eGjNuO_XYDocWzMANr3D0f8FPEffr9PTTGHrbcLDMB2mDS2M0FvACQnr0QztHvs-Xed33s2mi_jRT-3BalnCPOFQx2mc7eR3gGMHMGAz9AHMB3TWJAF8PM0L9Pv66tflbXb38-b75be7zLKylFnNpVSMWyqVFVVVu9oJaBJGXMlpI3gtnKXOcGgaKqRxqlSMFbbijtcFq9kF-nz0HcbwZ4Y46a2PFrrO9BDmqCWRnIuCJKI6Eu0YYhyh0cPotykkTYleutAbvUSul8j10oU-dKGfkvTT6Y-53oL7LzyFnwhfj4RH38H-1cb6x8N9WtgLOw-cGQ</recordid><startdate>200806</startdate><enddate>200806</enddate><creator>WALSH, JENNIFER H.</creator><creator>LEIGH, MATTHEW S.</creator><creator>PADUCH, ALEXANDRE</creator><creator>MADDISON, KATHLEEN J.</creator><creator>PHILIPPE, DANIELLE L.</creator><creator>ARMSTRONG, JULIAN J.</creator><creator>SAMPSON, DAVID D.</creator><creator>HILLMAN, DAVID R.</creator><creator>EASTWOOD, PETER R.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200806</creationdate><title>Evaluation of pharyngeal shape and size using anatomical optical coherence tomography in individuals with and without obstructive sleep apnoea</title><author>WALSH, JENNIFER H. ; LEIGH, MATTHEW S. ; PADUCH, ALEXANDRE ; MADDISON, KATHLEEN J. ; PHILIPPE, DANIELLE L. ; ARMSTRONG, JULIAN J. ; SAMPSON, DAVID D. ; HILLMAN, DAVID R. ; EASTWOOD, PETER R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3667-b477834c178c599bdbd5efc360d641f54b5dc1da4eff157ad868332c94d4b23b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Airway Resistance - physiology</topic><topic>Anthropometry</topic><topic>Endoscopes</topic><topic>Female</topic><topic>Humans</topic><topic>Hypopharynx - pathology</topic><topic>Hypopharynx - physiopathology</topic><topic>Image Processing, Computer-Assisted</topic><topic>imaging</topic><topic>Male</topic><topic>Matched-Pair Analysis</topic><topic>Middle Aged</topic><topic>obstructive sleep apnoea</topic><topic>optical coherence tomography</topic><topic>Oropharynx - pathology</topic><topic>Oropharynx - physiopathology</topic><topic>pharyngeal</topic><topic>pharynx</topic><topic>Pharynx - pathology</topic><topic>Pharynx - physiopathology</topic><topic>Pulmonary Ventilation - physiology</topic><topic>Reference Values</topic><topic>Sensitivity and Specificity</topic><topic>Sleep Apnea, Obstructive - pathology</topic><topic>Sleep Apnea, Obstructive - physiopathology</topic><topic>Tomography, Optical Coherence - instrumentation</topic><topic>Velopharyngeal Insufficiency - pathology</topic><topic>Velopharyngeal Insufficiency - physiopathology</topic><topic>Wakefulness - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WALSH, JENNIFER H.</creatorcontrib><creatorcontrib>LEIGH, MATTHEW S.</creatorcontrib><creatorcontrib>PADUCH, ALEXANDRE</creatorcontrib><creatorcontrib>MADDISON, KATHLEEN J.</creatorcontrib><creatorcontrib>PHILIPPE, DANIELLE L.</creatorcontrib><creatorcontrib>ARMSTRONG, JULIAN J.</creatorcontrib><creatorcontrib>SAMPSON, DAVID D.</creatorcontrib><creatorcontrib>HILLMAN, DAVID R.</creatorcontrib><creatorcontrib>EASTWOOD, PETER R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of sleep research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WALSH, JENNIFER H.</au><au>LEIGH, MATTHEW S.</au><au>PADUCH, ALEXANDRE</au><au>MADDISON, KATHLEEN J.</au><au>PHILIPPE, DANIELLE L.</au><au>ARMSTRONG, JULIAN J.</au><au>SAMPSON, DAVID D.</au><au>HILLMAN, DAVID R.</au><au>EASTWOOD, PETER R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of pharyngeal shape and size using anatomical optical coherence tomography in individuals with and without obstructive sleep apnoea</atitle><jtitle>Journal of sleep research</jtitle><addtitle>J Sleep Res</addtitle><date>2008-06</date><risdate>2008</risdate><volume>17</volume><issue>2</issue><spage>230</spage><epage>238</epage><pages>230-238</pages><issn>0962-1105</issn><eissn>1365-2869</eissn><abstract>Summary
This study compared shape, size and length of the pharyngeal airway in individuals with and without obstructive sleep apnoea (OSA) using a novel endoscopic imaging technique, anatomical optical coherence tomography (aOCT). The study population comprised a preliminary study group of 20 OSA patients and a subsequent controlled study group of 10 OSA patients and 10 body mass index (BMI)‐, gender‐ and age‐matched control subjects without OSA. All subjects were scanned using aOCT while awake, supine and breathing quietly. Measurements of airway cross‐sectional area (CSA) and anteroposterior (A‐P) and lateral diameters were obtained from the hypo‐, oro‐ and velopharyngeal regions. A‐P : lateral diameter ratios were calculated to provide an index of regional airway shape. In all subjects, pharyngeal CSA was lowest in the velopharynx. Patients with OSA had a smaller velopharyngeal CSA than controls (maximum CSA 91 ± 40 versus 153 ± 84 mm2; P < 0.05) but comparable oro‐ (318 ± 80 versus 279 ± 129 mm2; P = 0.48) and hypopharyngeal CSA (250 ± 105 versus 303 ± 112 mm2; P = 0.36). In each pharyngeal region, the long axis of the airway was oriented in the lateral diameter. Airway shape was not different between the groups. Pharyngeal airway length was similar in both groups, although the OSA group had longer uvulae than the control group (16.8 ± 6.2 versus 11.2 ± 5.2 mm; P < 0.05). This study has shown that individuals with OSA have a smaller velopharyngeal CSA than BMI‐, gender‐ and age‐matched control volunteers, but comparable shape: a laterally oriented ellipse. These findings suggest that it is an abnormality in size rather than shape that is the more important anatomical predictor of OSA.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18422508</pmid><doi>10.1111/j.1365-2869.2008.00647.x</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection) |
| subjects | Adult Aged Airway Resistance - physiology Anthropometry Endoscopes Female Humans Hypopharynx - pathology Hypopharynx - physiopathology Image Processing, Computer-Assisted imaging Male Matched-Pair Analysis Middle Aged obstructive sleep apnoea optical coherence tomography Oropharynx - pathology Oropharynx - physiopathology pharyngeal pharynx Pharynx - pathology Pharynx - physiopathology Pulmonary Ventilation - physiology Reference Values Sensitivity and Specificity Sleep Apnea, Obstructive - pathology Sleep Apnea, Obstructive - physiopathology Tomography, Optical Coherence - instrumentation Velopharyngeal Insufficiency - pathology Velopharyngeal Insufficiency - physiopathology Wakefulness - physiology |
| title | Evaluation of pharyngeal shape and size using anatomical optical coherence tomography in individuals with and without obstructive sleep apnoea |
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