Select paramyxoviral V proteins inhibit IRF3 activation by acting as alternative substrates for inhibitor of kappaB kinase epsilon (IKKe)/TBK1

V accessory proteins from Paramyxoviruses are important in viral evasion of the innate immune response. Here, using a cell survival assay that identifies both inhibitors and activators of interferon regulatory factor 3 (IRF3)-mediated gene induction, we identified select paramyxoviral V proteins tha...

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Veröffentlicht in:The Journal of biological chemistry 2008-05, Vol.283 (21), p.14269-14276
Hauptverfasser: Lu, Lenette L, Puri, Mamta, Horvath, Curt M, Sen, Ganes C
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Sprache:eng
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