Methodological Approaches to Optimize Reproducibility and Power in Clinical Studies of Flow-Mediated Dilation
Methodological Approaches to Optimize Reproducibility and Power in Clinical Studies of Flow-Mediated Dilation Ann E. Donald, Julian P. Halcox, Marietta Charakida, Clare Storry, Sharon M. L. Wallace, Tim J. Cole, Peter Friberg, John E. Deanfield We assessed the reproducibility of components of the fl...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2008-05, Vol.51 (20), p.1959-1964 |
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| creator | Donald, Ann E., AVS Halcox, Julian P., MD, MA, FRCP Charakida, Marietta, MD, PhD Storry, Clare, BSc, AVS Wallace, Sharon M.L., BA, DipHE, RN Cole, Tim J., ScD Friberg, Peter, MD, PhD Deanfield, John E., BA, BChir, MB, FRCP |
| description | Methodological Approaches to Optimize Reproducibility and Power in Clinical Studies of Flow-Mediated Dilation Ann E. Donald, Julian P. Halcox, Marietta Charakida, Clare Storry, Sharon M. L. Wallace, Tim J. Cole, Peter Friberg, John E. Deanfield We assessed the reproducibility of components of the flow-mediated dilation (FMD) response and their ability to discriminate between health and disease. The peak FMD was the most reproducible. All components except the time to peak were significantly lower in subjects with risk factors. Power curves generated from these results can be used to inform on the appropriate number of subjects for clinical trials. |
| doi_str_mv | 10.1016/j.jacc.2008.02.044 |
| format | Article |
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Donald, Julian P. Halcox, Marietta Charakida, Clare Storry, Sharon M. L. Wallace, Tim J. Cole, Peter Friberg, John E. Deanfield We assessed the reproducibility of components of the flow-mediated dilation (FMD) response and their ability to discriminate between health and disease. The peak FMD was the most reproducible. All components except the time to peak were significantly lower in subjects with risk factors. Power curves generated from these results can be used to inform on the appropriate number of subjects for clinical trials.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2008.02.044</identifier><identifier>PMID: 18482664</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Age ; Aged ; Atherosclerosis ; Cardiology ; Cardiovascular ; Clinical Trials as Topic - standards ; Coronary vessels ; Diabetes ; Diabetes Mellitus, Type 2 - diagnostic imaging ; Diabetes Mellitus, Type 2 - physiopathology ; Endothelium, Vascular - diagnostic imaging ; Endothelium, Vascular - physiology ; Endothelium, Vascular - physiopathology ; Female ; Humans ; Hypercholesterolemia - diagnostic imaging ; Hypercholesterolemia - physiopathology ; Internal Medicine ; Male ; Men ; Middle Aged ; Regional Blood Flow ; Reproducibility of Results ; Standard deviation ; Studies ; Ultrasonography - methods ; Vasodilation</subject><ispartof>Journal of the American College of Cardiology, 2008-05, Vol.51 (20), p.1959-1964</ispartof><rights>American College of Cardiology Foundation</rights><rights>2008 American College of Cardiology Foundation</rights><rights>Copyright Elsevier Limited May 20, 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c583t-8198968c0e73c790e78d5cc9d1ec1db6ea684076ecbc65c8e9397faff7520a1f3</citedby><cites>FETCH-LOGICAL-c583t-8198968c0e73c790e78d5cc9d1ec1db6ea684076ecbc65c8e9397faff7520a1f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0735109708008723$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18482664$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Donald, Ann E., AVS</creatorcontrib><creatorcontrib>Halcox, Julian P., MD, MA, FRCP</creatorcontrib><creatorcontrib>Charakida, Marietta, MD, PhD</creatorcontrib><creatorcontrib>Storry, Clare, BSc, AVS</creatorcontrib><creatorcontrib>Wallace, Sharon M.L., BA, DipHE, RN</creatorcontrib><creatorcontrib>Cole, Tim J., ScD</creatorcontrib><creatorcontrib>Friberg, Peter, MD, PhD</creatorcontrib><creatorcontrib>Deanfield, John E., BA, BChir, MB, FRCP</creatorcontrib><title>Methodological Approaches to Optimize Reproducibility and Power in Clinical Studies of Flow-Mediated Dilation</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Methodological Approaches to Optimize Reproducibility and Power in Clinical Studies of Flow-Mediated Dilation Ann E. Donald, Julian P. Halcox, Marietta Charakida, Clare Storry, Sharon M. L. Wallace, Tim J. Cole, Peter Friberg, John E. Deanfield We assessed the reproducibility of components of the flow-mediated dilation (FMD) response and their ability to discriminate between health and disease. The peak FMD was the most reproducible. All components except the time to peak were significantly lower in subjects with risk factors. 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Halcox, Julian P., MD, MA, FRCP ; Charakida, Marietta, MD, PhD ; Storry, Clare, BSc, AVS ; Wallace, Sharon M.L., BA, DipHE, RN ; Cole, Tim J., ScD ; Friberg, Peter, MD, PhD ; Deanfield, John E., BA, BChir, MB, FRCP</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c583t-8198968c0e73c790e78d5cc9d1ec1db6ea684076ecbc65c8e9397faff7520a1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Atherosclerosis</topic><topic>Cardiology</topic><topic>Cardiovascular</topic><topic>Clinical Trials as Topic - standards</topic><topic>Coronary vessels</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - diagnostic imaging</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Endothelium, Vascular - diagnostic imaging</topic><topic>Endothelium, Vascular - physiology</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypercholesterolemia - diagnostic imaging</topic><topic>Hypercholesterolemia - physiopathology</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Men</topic><topic>Middle Aged</topic><topic>Regional Blood Flow</topic><topic>Reproducibility of Results</topic><topic>Standard deviation</topic><topic>Studies</topic><topic>Ultrasonography - methods</topic><topic>Vasodilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Donald, Ann E., AVS</creatorcontrib><creatorcontrib>Halcox, Julian P., MD, MA, FRCP</creatorcontrib><creatorcontrib>Charakida, Marietta, MD, PhD</creatorcontrib><creatorcontrib>Storry, Clare, BSc, AVS</creatorcontrib><creatorcontrib>Wallace, Sharon M.L., BA, DipHE, RN</creatorcontrib><creatorcontrib>Cole, Tim J., ScD</creatorcontrib><creatorcontrib>Friberg, Peter, MD, PhD</creatorcontrib><creatorcontrib>Deanfield, John E., BA, BChir, MB, FRCP</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Donald, Ann E., AVS</au><au>Halcox, Julian P., MD, MA, FRCP</au><au>Charakida, Marietta, MD, PhD</au><au>Storry, Clare, BSc, AVS</au><au>Wallace, Sharon M.L., BA, DipHE, RN</au><au>Cole, Tim J., ScD</au><au>Friberg, Peter, MD, PhD</au><au>Deanfield, John E., BA, BChir, MB, FRCP</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methodological Approaches to Optimize Reproducibility and Power in Clinical Studies of Flow-Mediated Dilation</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2008-05-20</date><risdate>2008</risdate><volume>51</volume><issue>20</issue><spage>1959</spage><epage>1964</epage><pages>1959-1964</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><abstract>Methodological Approaches to Optimize Reproducibility and Power in Clinical Studies of Flow-Mediated Dilation Ann E. Donald, Julian P. Halcox, Marietta Charakida, Clare Storry, Sharon M. L. Wallace, Tim J. Cole, Peter Friberg, John E. Deanfield We assessed the reproducibility of components of the flow-mediated dilation (FMD) response and their ability to discriminate between health and disease. The peak FMD was the most reproducible. All components except the time to peak were significantly lower in subjects with risk factors. Power curves generated from these results can be used to inform on the appropriate number of subjects for clinical trials.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18482664</pmid><doi>10.1016/j.jacc.2008.02.044</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Aged Atherosclerosis Cardiology Cardiovascular Clinical Trials as Topic - standards Coronary vessels Diabetes Diabetes Mellitus, Type 2 - diagnostic imaging Diabetes Mellitus, Type 2 - physiopathology Endothelium, Vascular - diagnostic imaging Endothelium, Vascular - physiology Endothelium, Vascular - physiopathology Female Humans Hypercholesterolemia - diagnostic imaging Hypercholesterolemia - physiopathology Internal Medicine Male Men Middle Aged Regional Blood Flow Reproducibility of Results Standard deviation Studies Ultrasonography - methods Vasodilation |
| title | Methodological Approaches to Optimize Reproducibility and Power in Clinical Studies of Flow-Mediated Dilation |
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