Antagonism of p66shc by melanoma inhibitory activity

The p66shc protein governs oxidant stress and mammalian lifespan. Here, we identify melanoma inhibitory activity (MIA), a protein secreted by melanoma cells, as a novel binding partner and antagonist of p66shc. The N-terminal collagen homology-2 (CH2) domain of p66shc binds to the Src Homology-3 (SH...

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Veröffentlicht in:	Cell death and differentiation 2007-08, Vol.14 (8), p.1414-1421
Hauptverfasser:	Kasuno, K, Naqvi, A, DeRicco, J, Yamamori, T, Santhanam, L, Mattagajasingh, I, Yang, S, Meyskens, F L, Bosserhoff, A-K, Irani, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapter proteins Adaptor Proteins, Signal Transducing - antagonists & inhibitors Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - metabolism Animals Apoptosis Binding Sites Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Cell death Cell Line, Tumor Cercopithecus aethiops Collagen COS Cells Endoplasmic reticulum Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Growth factors Humans Hydrogen Peroxide - metabolism Kinases Life Sciences Melanoma Melanoma - genetics Melanoma - metabolism Melanoma - pathology Metastasis Mice Neoplasm Proteins - genetics Neoplasm Proteins - metabolism original-paper Oxidative Stress Phosphorylation Protein Binding Shc Signaling Adaptor Proteins Skin cancer Src Homology 2 Domain-Containing, Transforming Protein 1 Stem Cells Ultraviolet radiation
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