Cytokine-mediated FOXO3a phosphorylation suppresses FasL expression in hemopoietic cell lines: Investigations of the role of Fas in apoptosis due to cytokine starvation

We have investigated phosphatidylinositol 3-kinase (PI3K)-dependent survival signalling pathways using several cytokines in three different hemopoietic cell lines, MC/9, FDC-P1, and TF-1. Cytokines caused PI3K- and PKB-dependent phosphorylation of FOXO3a (previously known as FKHRL1) at three distinc...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2007-05, Vol.38 (2), p.74-83
Hauptverfasser:	Behzad, Hayedeh, Jamil, Sarwat, Denny, Trisha A., Duronio, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - physiology Cell Line, Tumor Cytokine Cytokines - deficiency Cytokines - physiology Down-Regulation - physiology Fas Ligand Protein - antagonists & inhibitors Fas Ligand Protein - biosynthesis Fas Ligand Protein - genetics fas Receptor - physiology Forkhead Box Protein O3 Forkhead Transcription Factors - physiology Hematopoiesis - physiology Humans Mice Phosphatidylinositol 3-Kinases - physiology Phosphorylation Protein kinase Proto-Oncogene Proteins c-akt - physiology Signal transduction Transcription factor
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