Transdermal and dermal delivery of adefovir: Effects of pH and permeation enhancers

The objective of this work was to investigate feasibility of transdermal and dermal delivery of adefovir (9-(2-phosphonomethoxyethyl)adenine), a broad-spectrum antiviral from the class of acyclic nucleoside phosphonates. Transport of 2% adefovir through and into porcine skin and effects of various s...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2008-06, Vol.69 (2), p.597-604
Hauptverfasser:	VAVROVA, Katerina, LORENCOVA, Katerina, KLIMENTOVA, Jana, NOVOTNY, Jakub, HOLY, Antoinin, HRABALEK, Alexandr
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclic nucleoside phosphonates Adefovir Adenine - administration & dosage Adenine - analogs & derivatives Adenine - pharmacokinetics Administration, Cutaneous Antiviral Agents - administration & dosage Antiviral Agents - pharmacokinetics Biological and medical sciences Chromatography, High Pressure Liquid Drug Delivery Systems Excipients General pharmacology Humans Hydrogen-Ion Concentration In Vitro Techniques Medical sciences Organophosphonates - administration & dosage Organophosphonates - pharmacokinetics Permeability Permeation enhancer Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Skin absorption Skin Absorption - drug effects Solvents Transdermal drug delivery
Online-Zugang:	Volltext
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