Advances in the synthesis of amphiphilic block copolymers via RAFT polymerization: Stimuli-responsive drug and gene delivery
Controlled/‘living’ radical polymerization methods, including the versatile reversible addition–fragmentation chain transfer (RAFT) polymerization process, are rapidly moving to the forefront in construction of drug and gene delivery vehicles. The RAFT technique allows an unprecedented latitude in t...
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| Veröffentlicht in: | Advanced drug delivery reviews 2008-06, Vol.60 (9), p.1018-1036 |
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| container_issue | 9 |
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| container_title | Advanced drug delivery reviews |
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| creator | York, Adam W. Kirkland, Stacey E. McCormick, Charles L. |
| description | Controlled/‘living’ radical polymerization methods, including the versatile reversible addition–fragmentation chain transfer (RAFT) polymerization process, are rapidly moving to the forefront in construction of drug and gene delivery vehicles. The RAFT technique allows an unprecedented latitude in the synthesis of water soluble or amphiphilic architectures with precise dimensions and appropriate functionality for attachment and targeted delivery of diagnostic and therapeutic agents. This review focuses on the chemistry of the RAFT process and its potential for preparing well-defined block copolymers and conjugates capable of stimuli-responsive assembly and release of bioactive agents in the physiological environment. Recent examples of block copolymers with designed structures and segmental compositions responsive to changes in pH or temperature are reviewed and hurdles facing further development of these novel systems are discussed. |
| doi_str_mv | 10.1016/j.addr.2008.02.006 |
| format | Article |
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Recent examples of block copolymers with designed structures and segmental compositions responsive to changes in pH or temperature are reviewed and hurdles facing further development of these novel systems are discussed.</description><subject>Bioconjugation</subject><subject>Controlled release</subject><subject>Cross-linked micelles</subject><subject>Delayed-Action Preparations</subject><subject>Drug Delivery Systems</subject><subject>Electrolytes - chemistry</subject><subject>Gene Transfer Techniques</subject><subject>Hydrogen-Ion Concentration</subject><subject>Interpolyelectrolyte complexes</subject><subject>Micelles</subject><subject>Polymers - chemistry</subject><subject>Prodrugs - chemistry</subject><subject>Stimuli-responsive polymers</subject><subject>Targeted delivery</subject><subject>Temperature</subject><subject>Water soluble polymers</subject><issn>0169-409X</issn><issn>1872-8294</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVGL1DAQx4Mo3nr6BXyQPPnWOknTJhVfluNOhQNBT_AtpMn0Lmvb1KRdWPHDm2UXfPNgYJjhN39IfoS8ZlAyYM27XWmciyUHUCXwEqB5QjZMSV4o3oqnZJOhthDQ_rggL1LaATAuG3hOLpgSUIEQG_Jn6_Zmspion-jygDQdptySTzT01Izzg881eEu7Idif1IY5DIcRY6J7b-jX7c0dPW_8b7P4ML2n3xY_roMvIqY5TMnvkbq43lMzOXqPU55wyMt4eEme9WZI-OrcL8n3m-u7q0_F7ZePn6-2t4UVii8F6yxa2ShlGteKJr9BCsfq2oiOtayGjsnKGWlq1ZmqMp2o2hpl32MnBbPAqkvy9pQ7x_BrxbTo0SeLw2AmDGvSEqSoagWPghVXvGnq5lGQtS1wJo8gP4E2hpQi9nqOfjTxoBnoo0W900eL-mhRA9fZYj56c05fuxHdv5Oztgx8OAGYf23vMepkPWaNzke0i3bB_y__L8U5r4U</recordid><startdate>20080610</startdate><enddate>20080610</enddate><creator>York, Adam W.</creator><creator>Kirkland, Stacey E.</creator><creator>McCormick, Charles L.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7U5</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20080610</creationdate><title>Advances in the synthesis of amphiphilic block copolymers via RAFT polymerization: Stimuli-responsive drug and gene delivery</title><author>York, Adam W. ; 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| fulltext | fulltext |
| identifier | ISSN: 0169-409X |
| ispartof | Advanced drug delivery reviews, 2008-06, Vol.60 (9), p.1018-1036 |
| issn | 0169-409X 1872-8294 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Bioconjugation Controlled release Cross-linked micelles Delayed-Action Preparations Drug Delivery Systems Electrolytes - chemistry Gene Transfer Techniques Hydrogen-Ion Concentration Interpolyelectrolyte complexes Micelles Polymers - chemistry Prodrugs - chemistry Stimuli-responsive polymers Targeted delivery Temperature Water soluble polymers |
| title | Advances in the synthesis of amphiphilic block copolymers via RAFT polymerization: Stimuli-responsive drug and gene delivery |
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