Study on the association of BoLA-DRB3.2 alleles with clinical mastitis in Norwegian Red cows
Genotyping of bovine leucocyte antigen DRB3.2 (BoLA-DRB3.2) in a total of 523 Norwegian Red (NR) cows from two groups selected for high protein yield and low clinical mastitis, respectively, identified 27 previously reported BoLA-DRB3.2 alleles across the groups. Significant differences in BoLA-DRB3...
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| Veröffentlicht in: | Journal of animal breeding and genetics (1986) 2007-08, Vol.124 (4), p.201-207 |
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| container_title | Journal of animal breeding and genetics (1986) |
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| creator | Kulberg, S Heringstad, B Guttersrud, O.A Olsaker, I |
| description | Genotyping of bovine leucocyte antigen DRB3.2 (BoLA-DRB3.2) in a total of 523 Norwegian Red (NR) cows from two groups selected for high protein yield and low clinical mastitis, respectively, identified 27 previously reported BoLA-DRB3.2 alleles across the groups. Significant differences in BoLA-DRB3.2 allele frequencies were found between the selection groups. Alleles *13, *18, *22 and *27 had a significantly higher frequency in cows selected for low clinical mastitis, while alleles *3, *9, *11 and *26 had a higher frequency in cows selected for high protein yield. Associations between BoLA-DRB3.2 alleles and clinical mastitis were analysed based on mastitis data from 741 072 first-lactation NR cows, of which 452 were genotyped. Alleles *22 and *26 were found to be associated with increased clinical mastitis, while alleles *7, *11, *18 and *24 had a favourable effect on mastitis resistance. Contradictory results from different studies investigating associations between BoLA-DRB3.2 alleles and mastitis indicate that future studies should focus on associations of mastitis with BoLA haplotypes rather than with single BoLA genes. |
| doi_str_mv | 10.1111/j.1439-0388.2007.00662.x |
| format | Article |
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Significant differences in BoLA-DRB3.2 allele frequencies were found between the selection groups. Alleles *13, *18, *22 and *27 had a significantly higher frequency in cows selected for low clinical mastitis, while alleles *3, *9, *11 and *26 had a higher frequency in cows selected for high protein yield. Associations between BoLA-DRB3.2 alleles and clinical mastitis were analysed based on mastitis data from 741 072 first-lactation NR cows, of which 452 were genotyped. Alleles *22 and *26 were found to be associated with increased clinical mastitis, while alleles *7, *11, *18 and *24 had a favourable effect on mastitis resistance. Contradictory results from different studies investigating associations between BoLA-DRB3.2 alleles and mastitis indicate that future studies should focus on associations of mastitis with BoLA haplotypes rather than with single BoLA genes.</description><identifier>ISSN: 0931-2668</identifier><identifier>EISSN: 1439-0388</identifier><identifier>DOI: 10.1111/j.1439-0388.2007.00662.x</identifier><identifier>PMID: 17651322</identifier><language>eng</language><publisher>Oxford, UK: Oxford, UK : Blackwell Publishing Ltd</publisher><subject>Animals ; Bovine leucocyte antigens ; Cattle - genetics ; clinical mastitis ; disease association ; Female ; Gene Frequency ; Genotype ; Histocompatibility Antigens Class II - genetics ; Mastitis, Bovine - epidemiology ; Mastitis, Bovine - genetics ; Models, Statistical ; Norway ; Norwegian Red ; selection experiment ; Species Specificity</subject><ispartof>Journal of animal breeding and genetics (1986), 2007-08, Vol.124 (4), p.201-207</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4592-fd4448a39475a1caa87a031e14b9c2646330c9a41116a1b6a3dc3559d9de7a793</citedby><cites>FETCH-LOGICAL-c4592-fd4448a39475a1caa87a031e14b9c2646330c9a41116a1b6a3dc3559d9de7a793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1439-0388.2007.00662.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1439-0388.2007.00662.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17651322$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kulberg, S</creatorcontrib><creatorcontrib>Heringstad, B</creatorcontrib><creatorcontrib>Guttersrud, O.A</creatorcontrib><creatorcontrib>Olsaker, I</creatorcontrib><title>Study on the association of BoLA-DRB3.2 alleles with clinical mastitis in Norwegian Red cows</title><title>Journal of animal breeding and genetics (1986)</title><addtitle>J Anim Breed Genet</addtitle><description>Genotyping of bovine leucocyte antigen DRB3.2 (BoLA-DRB3.2) in a total of 523 Norwegian Red (NR) cows from two groups selected for high protein yield and low clinical mastitis, respectively, identified 27 previously reported BoLA-DRB3.2 alleles across the groups. Significant differences in BoLA-DRB3.2 allele frequencies were found between the selection groups. Alleles *13, *18, *22 and *27 had a significantly higher frequency in cows selected for low clinical mastitis, while alleles *3, *9, *11 and *26 had a higher frequency in cows selected for high protein yield. Associations between BoLA-DRB3.2 alleles and clinical mastitis were analysed based on mastitis data from 741 072 first-lactation NR cows, of which 452 were genotyped. Alleles *22 and *26 were found to be associated with increased clinical mastitis, while alleles *7, *11, *18 and *24 had a favourable effect on mastitis resistance. Contradictory results from different studies investigating associations between BoLA-DRB3.2 alleles and mastitis indicate that future studies should focus on associations of mastitis with BoLA haplotypes rather than with single BoLA genes.</description><subject>Animals</subject><subject>Bovine leucocyte antigens</subject><subject>Cattle - genetics</subject><subject>clinical mastitis</subject><subject>disease association</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Histocompatibility Antigens Class II - genetics</subject><subject>Mastitis, Bovine - epidemiology</subject><subject>Mastitis, Bovine - genetics</subject><subject>Models, Statistical</subject><subject>Norway</subject><subject>Norwegian Red</subject><subject>selection experiment</subject><subject>Species Specificity</subject><issn>0931-2668</issn><issn>1439-0388</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV9v0zAUxS0EYt3gK4CfeEvwv9ixxMs6tg5UDWllGg9I1q3jbC5pPOJUbb_9HFKNx80v9rV_51j3XIQwJTlN6_Mqp4LrjPCyzBkhKidESpbvXqHJ08NrNCGa04xJWR6h4xhXhKR7pd-iI6pkQTljE_R70W-qPQ4t7u8dhhiD9dD7VIcaT8P8NPt6PeU5w9A0rnERb31_j23jW2-hwWuIve99xL7FV6HbujsPLb52FbZhG9-hNzU00b0_7Cfo5uL859llNv8x-3Z2Os-sKDTL6koIUQLXQhVALUCpgHDqqFhqy6SQnBOrQaTOJdClBF5ZXhS60pVToDQ_QZ9G34cu_N242Ju1j9Y1DbQubKJRRInULXkWZEQoVvABLEfQdiHGztXmofNr6PaGEjOMwKzMkLQZkjbDCMy_EZhdkn44_LFZrl31X3jIPAFfRmDrG7d_sbH5Pp2lQ5Jno9zH3u2e5ND9MVJxVZjbq5n5pZnSs8tbs0j8x5GvIRi463w0NwtGKE_emjLF-CMgaqrB</recordid><startdate>200708</startdate><enddate>200708</enddate><creator>Kulberg, S</creator><creator>Heringstad, B</creator><creator>Guttersrud, O.A</creator><creator>Olsaker, I</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200708</creationdate><title>Study on the association of BoLA-DRB3.2 alleles with clinical mastitis in Norwegian Red cows</title><author>Kulberg, S ; Heringstad, B ; Guttersrud, O.A ; Olsaker, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4592-fd4448a39475a1caa87a031e14b9c2646330c9a41116a1b6a3dc3559d9de7a793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Bovine leucocyte antigens</topic><topic>Cattle - genetics</topic><topic>clinical mastitis</topic><topic>disease association</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Histocompatibility Antigens Class II - genetics</topic><topic>Mastitis, Bovine - epidemiology</topic><topic>Mastitis, Bovine - genetics</topic><topic>Models, Statistical</topic><topic>Norway</topic><topic>Norwegian Red</topic><topic>selection experiment</topic><topic>Species Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kulberg, S</creatorcontrib><creatorcontrib>Heringstad, B</creatorcontrib><creatorcontrib>Guttersrud, O.A</creatorcontrib><creatorcontrib>Olsaker, I</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of animal breeding and genetics (1986)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kulberg, S</au><au>Heringstad, B</au><au>Guttersrud, O.A</au><au>Olsaker, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study on the association of BoLA-DRB3.2 alleles with clinical mastitis in Norwegian Red cows</atitle><jtitle>Journal of animal breeding and genetics (1986)</jtitle><addtitle>J Anim Breed Genet</addtitle><date>2007-08</date><risdate>2007</risdate><volume>124</volume><issue>4</issue><spage>201</spage><epage>207</epage><pages>201-207</pages><issn>0931-2668</issn><eissn>1439-0388</eissn><abstract>Genotyping of bovine leucocyte antigen DRB3.2 (BoLA-DRB3.2) in a total of 523 Norwegian Red (NR) cows from two groups selected for high protein yield and low clinical mastitis, respectively, identified 27 previously reported BoLA-DRB3.2 alleles across the groups. Significant differences in BoLA-DRB3.2 allele frequencies were found between the selection groups. Alleles *13, *18, *22 and *27 had a significantly higher frequency in cows selected for low clinical mastitis, while alleles *3, *9, *11 and *26 had a higher frequency in cows selected for high protein yield. Associations between BoLA-DRB3.2 alleles and clinical mastitis were analysed based on mastitis data from 741 072 first-lactation NR cows, of which 452 were genotyped. Alleles *22 and *26 were found to be associated with increased clinical mastitis, while alleles *7, *11, *18 and *24 had a favourable effect on mastitis resistance. Contradictory results from different studies investigating associations between BoLA-DRB3.2 alleles and mastitis indicate that future studies should focus on associations of mastitis with BoLA haplotypes rather than with single BoLA genes.</abstract><cop>Oxford, UK</cop><pub>Oxford, UK : Blackwell Publishing Ltd</pub><pmid>17651322</pmid><doi>10.1111/j.1439-0388.2007.00662.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Bovine leucocyte antigens Cattle - genetics clinical mastitis disease association Female Gene Frequency Genotype Histocompatibility Antigens Class II - genetics Mastitis, Bovine - epidemiology Mastitis, Bovine - genetics Models, Statistical Norway Norwegian Red selection experiment Species Specificity |
| title | Study on the association of BoLA-DRB3.2 alleles with clinical mastitis in Norwegian Red cows |
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