Long-term culture of multibacillary leprosy macrophages isolated from skin lesions: a new model to study Mycobacterium leprae-human cell interaction

Summary Background Leprosy is characterized by a disease spectrum having two polar clinical forms dependent on the presence or not of cell‐mediated immunity. In the tuberculoid forms, granuloma‐activated macrophages kill Mycobacterium leprae in conjunction with a Th1 response while, in multibacilla...

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Veröffentlicht in:	British journal of dermatology (1951) 2007-08, Vol.157 (2), p.273-283
Hauptverfasser:	Moura, D.F., Teles, R.M.B., Ribeiro-Carvalho, M.M., Teles, R.B., Santos, I.M.C.F., Ferreira, H., Fulco, T.O., Nery, J.A.C., Sampaio, E.P., Sarno, E.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Bacterial diseases Biological and medical sciences Cell Count Cells, Cultured cytokines Cytokines - biosynthesis Cytokines - genetics Dermatology Feasibility Studies Female Gene Expression Human bacterial diseases Humans infection Infectious diseases Leprosy Leprosy - immunology Leprosy, Borderline - immunology Leprosy, Lepromatous - immunology Leprosy, Tuberculoid - immunology macrophages Macrophages - immunology Macrophages - parasitology Male Medical sciences Middle Aged Models, Biological Mycobacterium Mycobacterium leprae Mycobacterium leprae - physiology Nitrites - metabolism Phagocytosis - immunology RNA, Messenger - genetics Skin - immunology Skin - parasitology Tropical bacterial diseases
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