Increased mucosal matrix metalloproteinase-1, -2, -3 and -9 activity in patients with inflammatory bowel disease and the relation with Crohn's disease phenotype

Abstract Background and objective Matrix metalloproteinases are associated with matrix turnover in both physiological and pathological conditions. We postulate an association between aberrant matrix metalloproteinases proteolytic activity and the intestinal tissue destruction, seen in patients with...

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Veröffentlicht in:	Digestive and liver disease 2007-08, Vol.39 (8), p.733-739
Hauptverfasser:	Meijer, M.J.W, Mieremet-Ooms, M.A.C, van der Zon, A.M, van Duijn, W, van Hogezand, R.A, Sier, C.F.M, Hommes, D.W, Lamers, C.B.H.W, Verspaget, H.W
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers - metabolism Colitis, Ulcerative - enzymology Colitis, Ulcerative - genetics Colitis, Ulcerative - pathology Crohn Disease - enzymology Crohn Disease - genetics Crohn Disease - pathology Enzyme-Linked Immunosorbent Assay Female Fibrosis Fistulae Follow-Up Studies Gastroenterology and Hepatology Humans IBD Intestinal Mucosa - enzymology Intestinal Mucosa - pathology Male Matrix Metalloproteinase 1 - biosynthesis Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 3 - biosynthesis Matrix Metalloproteinase 9 - biosynthesis MMP Phenotype Prognosis Prospective Studies Severity of Illness Index TIMP
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