An investigation into the relationship between carrier-based dry powder inhalation performance and formulation cohesive–adhesive force balances
The inclusion of different carrier materials in a dry powder inhaler (DPI) system can alter formulation performance, which might be attributable to variation in the adhesion between drug and carrier particles. The aim of this study was, therefore, to further examine the relationship between drug-car...
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Veröffentlicht in: | European journal of pharmaceutics and biopharmaceutics 2008-06, Vol.69 (2), p.496-507 |
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creator | Jones, Matthew D. Harris, Haggis Hooton, Jennifer C. Shur, Jagdeep King, Graeme S. Mathoulin, Camilla A. Nichol, Katrina Smith, Tracey L. Dawson, Michelle L. Ferrie, Alan R. Price, Robert |
description | The inclusion of different carrier materials in a dry powder inhaler (DPI) system can alter formulation performance, which might be attributable to variation in the adhesion between drug and carrier particles. The aim of this study was, therefore, to further examine the relationship between drug-carrier adhesion and performance, by comparing data relating to many different drug-carrier combinations. Four drugs and four carriers were employed, giving a total of 16 combinations. The relative magnitude of the drug-carrier adhesion for each combination was quantified using the cohesion–adhesion balance (CAB) approach to colloidal probe atomic force microscopy. The
in vitro inhalation performance of the 16 formulations (1.5% w/w drug) was investigated and found to vary significantly. Plots of fine particle dose against drug-carrier CAB ratio revealed that performance was optimised when the drug-carrier CAB ratio was slightly cohesive. This trend was found to fit with those from similar previous studies, although due to the smaller number of formulations investigated previously, the full extent of this relationship had not been revealed. It was concluded, therefore, that when developing a carrier-based DPI, the selection of a drug-carrier combination with a slightly cohesive CAB ratio might result in optimal performance. |
doi_str_mv | 10.1016/j.ejpb.2007.11.019 |
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in vitro inhalation performance of the 16 formulations (1.5% w/w drug) was investigated and found to vary significantly. Plots of fine particle dose against drug-carrier CAB ratio revealed that performance was optimised when the drug-carrier CAB ratio was slightly cohesive. This trend was found to fit with those from similar previous studies, although due to the smaller number of formulations investigated previously, the full extent of this relationship had not been revealed. It was concluded, therefore, that when developing a carrier-based DPI, the selection of a drug-carrier combination with a slightly cohesive CAB ratio might result in optimal performance.</description><identifier>ISSN: 0939-6411</identifier><identifier>EISSN: 1873-3441</identifier><identifier>DOI: 10.1016/j.ejpb.2007.11.019</identifier><identifier>PMID: 18191553</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adhesion ; Adhesiveness ; Administration, Inhalation ; Agglomerate ; Albuterol - administration & dosage ; Albuterol - analogs & derivatives ; Albuterol - chemistry ; Androstadienes - administration & dosage ; Androstadienes - chemistry ; Anti-Allergic Agents - administration & dosage ; Anti-Allergic Agents - chemistry ; Atomic force microscopy ; Biological and medical sciences ; Capsules ; Carrier ; Chemistry, Pharmaceutical ; Cohesion ; Crystallization ; Drug Carriers ; Dry powder inhaler ; Excipients ; Fluticasone ; General pharmacology ; Lactose - chemistry ; Medical sciences ; Microscopy, Atomic Force ; Microscopy, Electron, Scanning ; Particle Size ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Powders ; Salmeterol Xinafoate ; X-Ray Diffraction</subject><ispartof>European journal of pharmaceutics and biopharmaceutics, 2008-06, Vol.69 (2), p.496-507</ispartof><rights>2007 Elsevier B.V.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-350f986222a6f162300f2e500f6add5cf2c325667d3ff6c93013012b60bb55fb3</citedby><cites>FETCH-LOGICAL-c384t-350f986222a6f162300f2e500f6add5cf2c325667d3ff6c93013012b60bb55fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S093964110700402X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20383980$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18191553$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jones, Matthew D.</creatorcontrib><creatorcontrib>Harris, Haggis</creatorcontrib><creatorcontrib>Hooton, Jennifer C.</creatorcontrib><creatorcontrib>Shur, Jagdeep</creatorcontrib><creatorcontrib>King, Graeme S.</creatorcontrib><creatorcontrib>Mathoulin, Camilla A.</creatorcontrib><creatorcontrib>Nichol, Katrina</creatorcontrib><creatorcontrib>Smith, Tracey L.</creatorcontrib><creatorcontrib>Dawson, Michelle L.</creatorcontrib><creatorcontrib>Ferrie, Alan R.</creatorcontrib><creatorcontrib>Price, Robert</creatorcontrib><title>An investigation into the relationship between carrier-based dry powder inhalation performance and formulation cohesive–adhesive force balances</title><title>European journal of pharmaceutics and biopharmaceutics</title><addtitle>Eur J Pharm Biopharm</addtitle><description>The inclusion of different carrier materials in a dry powder inhaler (DPI) system can alter formulation performance, which might be attributable to variation in the adhesion between drug and carrier particles. The aim of this study was, therefore, to further examine the relationship between drug-carrier adhesion and performance, by comparing data relating to many different drug-carrier combinations. Four drugs and four carriers were employed, giving a total of 16 combinations. The relative magnitude of the drug-carrier adhesion for each combination was quantified using the cohesion–adhesion balance (CAB) approach to colloidal probe atomic force microscopy. The
in vitro inhalation performance of the 16 formulations (1.5% w/w drug) was investigated and found to vary significantly. Plots of fine particle dose against drug-carrier CAB ratio revealed that performance was optimised when the drug-carrier CAB ratio was slightly cohesive. This trend was found to fit with those from similar previous studies, although due to the smaller number of formulations investigated previously, the full extent of this relationship had not been revealed. It was concluded, therefore, that when developing a carrier-based DPI, the selection of a drug-carrier combination with a slightly cohesive CAB ratio might result in optimal performance.</description><subject>Adhesion</subject><subject>Adhesiveness</subject><subject>Administration, Inhalation</subject><subject>Agglomerate</subject><subject>Albuterol - administration & dosage</subject><subject>Albuterol - analogs & derivatives</subject><subject>Albuterol - chemistry</subject><subject>Androstadienes - administration & dosage</subject><subject>Androstadienes - chemistry</subject><subject>Anti-Allergic Agents - administration & dosage</subject><subject>Anti-Allergic Agents - chemistry</subject><subject>Atomic force microscopy</subject><subject>Biological and medical sciences</subject><subject>Capsules</subject><subject>Carrier</subject><subject>Chemistry, Pharmaceutical</subject><subject>Cohesion</subject><subject>Crystallization</subject><subject>Drug Carriers</subject><subject>Dry powder inhaler</subject><subject>Excipients</subject><subject>Fluticasone</subject><subject>General pharmacology</subject><subject>Lactose - chemistry</subject><subject>Medical sciences</subject><subject>Microscopy, Atomic Force</subject><subject>Microscopy, Electron, Scanning</subject><subject>Particle Size</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Powders</subject><subject>Salmeterol Xinafoate</subject><subject>X-Ray Diffraction</subject><issn>0939-6411</issn><issn>1873-3441</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhi0EokvLC3BAvsAtqcdOnETiUlUUkCr1Qs-WY49Zr3bjYGe36o1XQLwhT1KHRHBDsmyP5_tH438IeQOsBAbyclfibuxLzlhTApQMumdkA20jClFV8JxsWCe6QlYAZ-RVSjvGWNXU7UtyBi10UNdiQ35eDdQPJ0yT_6YnH-ZoCnTaIo24__OStn6kPU4PiAM1OkaPseh1QkttfKRjeLAYs2yrF56OGF2IBz0YpHqwdA6Oa86ELSZ_wt8_fmm7XOd8Jvssz4p0QV44vU_4ej3Pyf3Nx6_Xn4vbu09frq9uCyPaaipEzVzXSs65lg4kF4w5jnXepba2No4bwWspGyuck6YTDPLivWR9X9euF-fk_VJ3jOH7MRugDj4Z3OcuMByTaliTnWsgg3wBTQwpRXRqjP6g46MCpuZBqJ2aB6HmQSgAlQeRRW_X6sf-gPafZHU-A-9WQCej9y7mz_v0l-NMtKJrWeY-LBxmL07ZepWMx2yU9RHNpGzw_-vjCV2XqvU</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>Jones, Matthew D.</creator><creator>Harris, Haggis</creator><creator>Hooton, Jennifer C.</creator><creator>Shur, Jagdeep</creator><creator>King, Graeme S.</creator><creator>Mathoulin, Camilla A.</creator><creator>Nichol, Katrina</creator><creator>Smith, Tracey L.</creator><creator>Dawson, Michelle L.</creator><creator>Ferrie, Alan R.</creator><creator>Price, Robert</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080601</creationdate><title>An investigation into the relationship between carrier-based dry powder inhalation performance and formulation cohesive–adhesive force balances</title><author>Jones, Matthew D. ; Harris, Haggis ; Hooton, Jennifer C. ; Shur, Jagdeep ; King, Graeme S. ; Mathoulin, Camilla A. ; Nichol, Katrina ; Smith, Tracey L. ; Dawson, Michelle L. ; Ferrie, Alan R. ; Price, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-350f986222a6f162300f2e500f6add5cf2c325667d3ff6c93013012b60bb55fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adhesion</topic><topic>Adhesiveness</topic><topic>Administration, Inhalation</topic><topic>Agglomerate</topic><topic>Albuterol - administration & dosage</topic><topic>Albuterol - analogs & derivatives</topic><topic>Albuterol - chemistry</topic><topic>Androstadienes - administration & dosage</topic><topic>Androstadienes - chemistry</topic><topic>Anti-Allergic Agents - administration & dosage</topic><topic>Anti-Allergic Agents - chemistry</topic><topic>Atomic force microscopy</topic><topic>Biological and medical sciences</topic><topic>Capsules</topic><topic>Carrier</topic><topic>Chemistry, Pharmaceutical</topic><topic>Cohesion</topic><topic>Crystallization</topic><topic>Drug Carriers</topic><topic>Dry powder inhaler</topic><topic>Excipients</topic><topic>Fluticasone</topic><topic>General pharmacology</topic><topic>Lactose - chemistry</topic><topic>Medical sciences</topic><topic>Microscopy, Atomic Force</topic><topic>Microscopy, Electron, Scanning</topic><topic>Particle Size</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Powders</topic><topic>Salmeterol Xinafoate</topic><topic>X-Ray Diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jones, Matthew D.</creatorcontrib><creatorcontrib>Harris, Haggis</creatorcontrib><creatorcontrib>Hooton, Jennifer C.</creatorcontrib><creatorcontrib>Shur, Jagdeep</creatorcontrib><creatorcontrib>King, Graeme S.</creatorcontrib><creatorcontrib>Mathoulin, Camilla A.</creatorcontrib><creatorcontrib>Nichol, Katrina</creatorcontrib><creatorcontrib>Smith, Tracey L.</creatorcontrib><creatorcontrib>Dawson, Michelle L.</creatorcontrib><creatorcontrib>Ferrie, Alan R.</creatorcontrib><creatorcontrib>Price, Robert</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmaceutics and biopharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jones, Matthew D.</au><au>Harris, Haggis</au><au>Hooton, Jennifer C.</au><au>Shur, Jagdeep</au><au>King, Graeme S.</au><au>Mathoulin, Camilla A.</au><au>Nichol, Katrina</au><au>Smith, Tracey L.</au><au>Dawson, Michelle L.</au><au>Ferrie, Alan R.</au><au>Price, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An investigation into the relationship between carrier-based dry powder inhalation performance and formulation cohesive–adhesive force balances</atitle><jtitle>European journal of pharmaceutics and biopharmaceutics</jtitle><addtitle>Eur J Pharm Biopharm</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>69</volume><issue>2</issue><spage>496</spage><epage>507</epage><pages>496-507</pages><issn>0939-6411</issn><eissn>1873-3441</eissn><abstract>The inclusion of different carrier materials in a dry powder inhaler (DPI) system can alter formulation performance, which might be attributable to variation in the adhesion between drug and carrier particles. The aim of this study was, therefore, to further examine the relationship between drug-carrier adhesion and performance, by comparing data relating to many different drug-carrier combinations. Four drugs and four carriers were employed, giving a total of 16 combinations. The relative magnitude of the drug-carrier adhesion for each combination was quantified using the cohesion–adhesion balance (CAB) approach to colloidal probe atomic force microscopy. The
in vitro inhalation performance of the 16 formulations (1.5% w/w drug) was investigated and found to vary significantly. Plots of fine particle dose against drug-carrier CAB ratio revealed that performance was optimised when the drug-carrier CAB ratio was slightly cohesive. This trend was found to fit with those from similar previous studies, although due to the smaller number of formulations investigated previously, the full extent of this relationship had not been revealed. It was concluded, therefore, that when developing a carrier-based DPI, the selection of a drug-carrier combination with a slightly cohesive CAB ratio might result in optimal performance.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>18191553</pmid><doi>10.1016/j.ejpb.2007.11.019</doi><tpages>12</tpages></addata></record> |
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subjects | Adhesion Adhesiveness Administration, Inhalation Agglomerate Albuterol - administration & dosage Albuterol - analogs & derivatives Albuterol - chemistry Androstadienes - administration & dosage Androstadienes - chemistry Anti-Allergic Agents - administration & dosage Anti-Allergic Agents - chemistry Atomic force microscopy Biological and medical sciences Capsules Carrier Chemistry, Pharmaceutical Cohesion Crystallization Drug Carriers Dry powder inhaler Excipients Fluticasone General pharmacology Lactose - chemistry Medical sciences Microscopy, Atomic Force Microscopy, Electron, Scanning Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Powders Salmeterol Xinafoate X-Ray Diffraction |
title | An investigation into the relationship between carrier-based dry powder inhalation performance and formulation cohesive–adhesive force balances |
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