An investigation into the relationship between carrier-based dry powder inhalation performance and formulation cohesive–adhesive force balances

The inclusion of different carrier materials in a dry powder inhaler (DPI) system can alter formulation performance, which might be attributable to variation in the adhesion between drug and carrier particles. The aim of this study was, therefore, to further examine the relationship between drug-car...

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Veröffentlicht in:European journal of pharmaceutics and biopharmaceutics 2008-06, Vol.69 (2), p.496-507
Hauptverfasser: Jones, Matthew D., Harris, Haggis, Hooton, Jennifer C., Shur, Jagdeep, King, Graeme S., Mathoulin, Camilla A., Nichol, Katrina, Smith, Tracey L., Dawson, Michelle L., Ferrie, Alan R., Price, Robert
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container_issue 2
container_start_page 496
container_title European journal of pharmaceutics and biopharmaceutics
container_volume 69
creator Jones, Matthew D.
Harris, Haggis
Hooton, Jennifer C.
Shur, Jagdeep
King, Graeme S.
Mathoulin, Camilla A.
Nichol, Katrina
Smith, Tracey L.
Dawson, Michelle L.
Ferrie, Alan R.
Price, Robert
description The inclusion of different carrier materials in a dry powder inhaler (DPI) system can alter formulation performance, which might be attributable to variation in the adhesion between drug and carrier particles. The aim of this study was, therefore, to further examine the relationship between drug-carrier adhesion and performance, by comparing data relating to many different drug-carrier combinations. Four drugs and four carriers were employed, giving a total of 16 combinations. The relative magnitude of the drug-carrier adhesion for each combination was quantified using the cohesion–adhesion balance (CAB) approach to colloidal probe atomic force microscopy. The in vitro inhalation performance of the 16 formulations (1.5% w/w drug) was investigated and found to vary significantly. Plots of fine particle dose against drug-carrier CAB ratio revealed that performance was optimised when the drug-carrier CAB ratio was slightly cohesive. This trend was found to fit with those from similar previous studies, although due to the smaller number of formulations investigated previously, the full extent of this relationship had not been revealed. It was concluded, therefore, that when developing a carrier-based DPI, the selection of a drug-carrier combination with a slightly cohesive CAB ratio might result in optimal performance.
doi_str_mv 10.1016/j.ejpb.2007.11.019
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The aim of this study was, therefore, to further examine the relationship between drug-carrier adhesion and performance, by comparing data relating to many different drug-carrier combinations. Four drugs and four carriers were employed, giving a total of 16 combinations. The relative magnitude of the drug-carrier adhesion for each combination was quantified using the cohesion–adhesion balance (CAB) approach to colloidal probe atomic force microscopy. The in vitro inhalation performance of the 16 formulations (1.5% w/w drug) was investigated and found to vary significantly. Plots of fine particle dose against drug-carrier CAB ratio revealed that performance was optimised when the drug-carrier CAB ratio was slightly cohesive. This trend was found to fit with those from similar previous studies, although due to the smaller number of formulations investigated previously, the full extent of this relationship had not been revealed. 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Pharmaceutical industry</subject><subject>Pharmacology. 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Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Powders</topic><topic>Salmeterol Xinafoate</topic><topic>X-Ray Diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jones, Matthew D.</creatorcontrib><creatorcontrib>Harris, Haggis</creatorcontrib><creatorcontrib>Hooton, Jennifer C.</creatorcontrib><creatorcontrib>Shur, Jagdeep</creatorcontrib><creatorcontrib>King, Graeme S.</creatorcontrib><creatorcontrib>Mathoulin, Camilla A.</creatorcontrib><creatorcontrib>Nichol, Katrina</creatorcontrib><creatorcontrib>Smith, Tracey L.</creatorcontrib><creatorcontrib>Dawson, Michelle L.</creatorcontrib><creatorcontrib>Ferrie, Alan R.</creatorcontrib><creatorcontrib>Price, Robert</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmaceutics and biopharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jones, Matthew D.</au><au>Harris, Haggis</au><au>Hooton, Jennifer C.</au><au>Shur, Jagdeep</au><au>King, Graeme S.</au><au>Mathoulin, Camilla A.</au><au>Nichol, Katrina</au><au>Smith, Tracey L.</au><au>Dawson, Michelle L.</au><au>Ferrie, Alan R.</au><au>Price, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An investigation into the relationship between carrier-based dry powder inhalation performance and formulation cohesive–adhesive force balances</atitle><jtitle>European journal of pharmaceutics and biopharmaceutics</jtitle><addtitle>Eur J Pharm Biopharm</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>69</volume><issue>2</issue><spage>496</spage><epage>507</epage><pages>496-507</pages><issn>0939-6411</issn><eissn>1873-3441</eissn><abstract>The inclusion of different carrier materials in a dry powder inhaler (DPI) system can alter formulation performance, which might be attributable to variation in the adhesion between drug and carrier particles. The aim of this study was, therefore, to further examine the relationship between drug-carrier adhesion and performance, by comparing data relating to many different drug-carrier combinations. Four drugs and four carriers were employed, giving a total of 16 combinations. The relative magnitude of the drug-carrier adhesion for each combination was quantified using the cohesion–adhesion balance (CAB) approach to colloidal probe atomic force microscopy. The in vitro inhalation performance of the 16 formulations (1.5% w/w drug) was investigated and found to vary significantly. Plots of fine particle dose against drug-carrier CAB ratio revealed that performance was optimised when the drug-carrier CAB ratio was slightly cohesive. This trend was found to fit with those from similar previous studies, although due to the smaller number of formulations investigated previously, the full extent of this relationship had not been revealed. It was concluded, therefore, that when developing a carrier-based DPI, the selection of a drug-carrier combination with a slightly cohesive CAB ratio might result in optimal performance.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>18191553</pmid><doi>10.1016/j.ejpb.2007.11.019</doi><tpages>12</tpages></addata></record>
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source MEDLINE; Elsevier ScienceDirect Journals
subjects Adhesion
Adhesiveness
Administration, Inhalation
Agglomerate
Albuterol - administration & dosage
Albuterol - analogs & derivatives
Albuterol - chemistry
Androstadienes - administration & dosage
Androstadienes - chemistry
Anti-Allergic Agents - administration & dosage
Anti-Allergic Agents - chemistry
Atomic force microscopy
Biological and medical sciences
Capsules
Carrier
Chemistry, Pharmaceutical
Cohesion
Crystallization
Drug Carriers
Dry powder inhaler
Excipients
Fluticasone
General pharmacology
Lactose - chemistry
Medical sciences
Microscopy, Atomic Force
Microscopy, Electron, Scanning
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Powders
Salmeterol Xinafoate
X-Ray Diffraction
title An investigation into the relationship between carrier-based dry powder inhalation performance and formulation cohesive–adhesive force balances
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