Lornoxicam characteristically modulates cerebral pain-processing in human volunteers: a functional magnetic resonance imaging study

Lornoxicam like other non-steroidal anti-inflammatory drugs (NSAIDs) is widely used for postoperative pain therapy. Evaluation of the effect of lornoxicam on cerebral processing of surgical pain was thus the aim of the present functional magnetic resonance imaging (fMRI) study. An fMRI-compatible pa...

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Veröffentlicht in:British journal of anaesthesia : BJA 2008-06, Vol.100 (6), p.827-833
Hauptverfasser: Lorenz, I.H., Egger, K., Schubert, H., Schnürer, C., Tiefenthaler, W., Hohlrieder, M., Schocke, M.F., Kremser, C., Esterhammer, R., Ischebeck, A., Moser, P.L., Kolbitsch, C.
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container_issue 6
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container_title British journal of anaesthesia : BJA
container_volume 100
creator Lorenz, I.H.
Egger, K.
Schubert, H.
Schnürer, C.
Tiefenthaler, W.
Hohlrieder, M.
Schocke, M.F.
Kremser, C.
Esterhammer, R.
Ischebeck, A.
Moser, P.L.
Kolbitsch, C.
description Lornoxicam like other non-steroidal anti-inflammatory drugs (NSAIDs) is widely used for postoperative pain therapy. Evaluation of the effect of lornoxicam on cerebral processing of surgical pain was thus the aim of the present functional magnetic resonance imaging (fMRI) study. An fMRI-compatible pain model that mimics surgical pain was used to induce pain rated 4–5 on a visual analogue scale (VAS) at the anterior margin of the right tibia in volunteers (n=22) after i.v. administration of saline (n=11) or lornoxicam (0.1 mg kg−1) (n=11). Lornoxicam, which significantly reduced pain sensation [VAS: mean (sd) 4.6 (0.7) vs 1.2 (1.5)], completely suppressed pain-induced activation in the SII/operculum, anterior cingulate cortex, insula, parietal (inferior), prefrontal (inferior, medial), temporal (inferior, medial/superior) lobe, cerebellum, and contralateral (e.g. left-sided) postcentral gyrus (SI). Only the hippocampus and the contralateral superior parietal lobe (BA 7) were activated. As compared with saline, lornoxicam typically suppressed pain-induced brain activation in all regions except the hippocampus. Furthermore, de novo activation was found in the contralateral, superior parietal lobe (BA 7).
doi_str_mv 10.1093/bja/aen082
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subjects Adult
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
brain
Brain - drug effects
Brain - physiopathology
Brain mapping
Brain Mapping - methods
brain, magnetic resonance imaging
brain, metabolism
brain, oxygen consumption
experimental
Humans
Magnetic Resonance Imaging
Male
metabolism
oxygen consumption
pain
Pain - etiology
Pain - physiopathology
Pain - prevention & control
Pain Measurement - methods
pain, experimental
Physical Stimulation
Piroxicam - analogs & derivatives
Piroxicam - pharmacology
Piroxicam - therapeutic use
Single-Blind Method
title Lornoxicam characteristically modulates cerebral pain-processing in human volunteers: a functional magnetic resonance imaging study
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