Lornoxicam characteristically modulates cerebral pain-processing in human volunteers: a functional magnetic resonance imaging study
Lornoxicam like other non-steroidal anti-inflammatory drugs (NSAIDs) is widely used for postoperative pain therapy. Evaluation of the effect of lornoxicam on cerebral processing of surgical pain was thus the aim of the present functional magnetic resonance imaging (fMRI) study. An fMRI-compatible pa...
Gespeichert in:
Veröffentlicht in: | British journal of anaesthesia : BJA 2008-06, Vol.100 (6), p.827-833 |
---|---|
Hauptverfasser: | , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 833 |
---|---|
container_issue | 6 |
container_start_page | 827 |
container_title | British journal of anaesthesia : BJA |
container_volume | 100 |
creator | Lorenz, I.H. Egger, K. Schubert, H. Schnürer, C. Tiefenthaler, W. Hohlrieder, M. Schocke, M.F. Kremser, C. Esterhammer, R. Ischebeck, A. Moser, P.L. Kolbitsch, C. |
description | Lornoxicam like other non-steroidal anti-inflammatory drugs (NSAIDs) is widely used for postoperative pain therapy. Evaluation of the effect of lornoxicam on cerebral processing of surgical pain was thus the aim of the present functional magnetic resonance imaging (fMRI) study.
An fMRI-compatible pain model that mimics surgical pain was used to induce pain rated 4–5 on a visual analogue scale (VAS) at the anterior margin of the right tibia in volunteers (n=22) after i.v. administration of saline (n=11) or lornoxicam (0.1 mg kg−1) (n=11).
Lornoxicam, which significantly reduced pain sensation [VAS: mean (sd) 4.6 (0.7) vs 1.2 (1.5)], completely suppressed pain-induced activation in the SII/operculum, anterior cingulate cortex, insula, parietal (inferior), prefrontal (inferior, medial), temporal (inferior, medial/superior) lobe, cerebellum, and contralateral (e.g. left-sided) postcentral gyrus (SI). Only the hippocampus and the contralateral superior parietal lobe (BA 7) were activated.
As compared with saline, lornoxicam typically suppressed pain-induced brain activation in all regions except the hippocampus. Furthermore, de novo activation was found in the contralateral, superior parietal lobe (BA 7). |
doi_str_mv | 10.1093/bja/aen082 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70740666</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/bja/aen082</oup_id><els_id>S0007091217343039</els_id><sourcerecordid>1499794081</sourcerecordid><originalsourceid>FETCH-LOGICAL-c494t-73f95fb98b5492d58250677fbe1b1d608ea6c18da87e9d0309e76eb62d88a4803</originalsourceid><addsrcrecordid>eNp90VFr1TAUB_AiirubvvgBJAiKCHVJmzaJbzI2J1xQUIf4EtL0dMu1Te6SZuw--8U9oxcFkT0FDr-c5Jx_UTxj9C2jqj7uNubYgKeyelCsGBesbIVgD4sVpVSUVLHqoDhMaUMpE5VqHhcHTPKaCs5Xxa91iD7cOmsmYq9MNHaG6NKMhXHckSn0eTQzJGIhQhfNSLbG-XIbg4WUnL8kzpOrPBlPbsKY_QwQ0ztiyJC9nV3weGMylx6wI4mQsOAtEIe1u8tpzv3uSfFoMGOCp_vzqPh2dvr15Lxcf_rw8eT9urRc8bkU9aCaoVOya7iq-kZWDcVBhw5Yx_qWSjCtZbI3UoDqaU0ViBa6tuqlNFzS-qh4tfTF319nSLOeXLIwjsZDyEkLXAlt2xbh63sh46qVqq7rCumLf-gm5IhTo1JCUqG4QPRmQTaGlCIMehtxA3GnGdV3EWqMUC8RIn6-75i7Cfq_dJ8ZgpcLCHl7f6NycRgn3P6RJv7UrahFo8-__9Bs_fmsuvjS6Av0fPGAGdw4iDpZB5hW7yLYWffB_e-Z30SGyC0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>197807947</pqid></control><display><type>article</type><title>Lornoxicam characteristically modulates cerebral pain-processing in human volunteers: a functional magnetic resonance imaging study</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Lorenz, I.H. ; Egger, K. ; Schubert, H. ; Schnürer, C. ; Tiefenthaler, W. ; Hohlrieder, M. ; Schocke, M.F. ; Kremser, C. ; Esterhammer, R. ; Ischebeck, A. ; Moser, P.L. ; Kolbitsch, C.</creator><creatorcontrib>Lorenz, I.H. ; Egger, K. ; Schubert, H. ; Schnürer, C. ; Tiefenthaler, W. ; Hohlrieder, M. ; Schocke, M.F. ; Kremser, C. ; Esterhammer, R. ; Ischebeck, A. ; Moser, P.L. ; Kolbitsch, C.</creatorcontrib><description>Lornoxicam like other non-steroidal anti-inflammatory drugs (NSAIDs) is widely used for postoperative pain therapy. Evaluation of the effect of lornoxicam on cerebral processing of surgical pain was thus the aim of the present functional magnetic resonance imaging (fMRI) study.
An fMRI-compatible pain model that mimics surgical pain was used to induce pain rated 4–5 on a visual analogue scale (VAS) at the anterior margin of the right tibia in volunteers (n=22) after i.v. administration of saline (n=11) or lornoxicam (0.1 mg kg−1) (n=11).
Lornoxicam, which significantly reduced pain sensation [VAS: mean (sd) 4.6 (0.7) vs 1.2 (1.5)], completely suppressed pain-induced activation in the SII/operculum, anterior cingulate cortex, insula, parietal (inferior), prefrontal (inferior, medial), temporal (inferior, medial/superior) lobe, cerebellum, and contralateral (e.g. left-sided) postcentral gyrus (SI). Only the hippocampus and the contralateral superior parietal lobe (BA 7) were activated.
As compared with saline, lornoxicam typically suppressed pain-induced brain activation in all regions except the hippocampus. Furthermore, de novo activation was found in the contralateral, superior parietal lobe (BA 7).</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/aen082</identifier><identifier>PMID: 18430744</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; brain ; Brain - drug effects ; Brain - physiopathology ; Brain mapping ; Brain Mapping - methods ; brain, magnetic resonance imaging ; brain, metabolism ; brain, oxygen consumption ; experimental ; Humans ; Magnetic Resonance Imaging ; Male ; metabolism ; oxygen consumption ; pain ; Pain - etiology ; Pain - physiopathology ; Pain - prevention & control ; Pain Measurement - methods ; pain, experimental ; Physical Stimulation ; Piroxicam - analogs & derivatives ; Piroxicam - pharmacology ; Piroxicam - therapeutic use ; Single-Blind Method</subject><ispartof>British journal of anaesthesia : BJA, 2008-06, Vol.100 (6), p.827-833</ispartof><rights>2008 British Journal of Anaesthesia</rights><rights>The Board of Management and Trustees of the British Journal of Anaesthesia 2008. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org 2008</rights><rights>Copyright Oxford Publishing Limited(England) Jun 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-73f95fb98b5492d58250677fbe1b1d608ea6c18da87e9d0309e76eb62d88a4803</citedby><cites>FETCH-LOGICAL-c494t-73f95fb98b5492d58250677fbe1b1d608ea6c18da87e9d0309e76eb62d88a4803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18430744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lorenz, I.H.</creatorcontrib><creatorcontrib>Egger, K.</creatorcontrib><creatorcontrib>Schubert, H.</creatorcontrib><creatorcontrib>Schnürer, C.</creatorcontrib><creatorcontrib>Tiefenthaler, W.</creatorcontrib><creatorcontrib>Hohlrieder, M.</creatorcontrib><creatorcontrib>Schocke, M.F.</creatorcontrib><creatorcontrib>Kremser, C.</creatorcontrib><creatorcontrib>Esterhammer, R.</creatorcontrib><creatorcontrib>Ischebeck, A.</creatorcontrib><creatorcontrib>Moser, P.L.</creatorcontrib><creatorcontrib>Kolbitsch, C.</creatorcontrib><title>Lornoxicam characteristically modulates cerebral pain-processing in human volunteers: a functional magnetic resonance imaging study</title><title>British journal of anaesthesia : BJA</title><addtitle>Br J Anaesth</addtitle><description>Lornoxicam like other non-steroidal anti-inflammatory drugs (NSAIDs) is widely used for postoperative pain therapy. Evaluation of the effect of lornoxicam on cerebral processing of surgical pain was thus the aim of the present functional magnetic resonance imaging (fMRI) study.
An fMRI-compatible pain model that mimics surgical pain was used to induce pain rated 4–5 on a visual analogue scale (VAS) at the anterior margin of the right tibia in volunteers (n=22) after i.v. administration of saline (n=11) or lornoxicam (0.1 mg kg−1) (n=11).
Lornoxicam, which significantly reduced pain sensation [VAS: mean (sd) 4.6 (0.7) vs 1.2 (1.5)], completely suppressed pain-induced activation in the SII/operculum, anterior cingulate cortex, insula, parietal (inferior), prefrontal (inferior, medial), temporal (inferior, medial/superior) lobe, cerebellum, and contralateral (e.g. left-sided) postcentral gyrus (SI). Only the hippocampus and the contralateral superior parietal lobe (BA 7) were activated.
As compared with saline, lornoxicam typically suppressed pain-induced brain activation in all regions except the hippocampus. Furthermore, de novo activation was found in the contralateral, superior parietal lobe (BA 7).</description><subject>Adult</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>brain</subject><subject>Brain - drug effects</subject><subject>Brain - physiopathology</subject><subject>Brain mapping</subject><subject>Brain Mapping - methods</subject><subject>brain, magnetic resonance imaging</subject><subject>brain, metabolism</subject><subject>brain, oxygen consumption</subject><subject>experimental</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>metabolism</subject><subject>oxygen consumption</subject><subject>pain</subject><subject>Pain - etiology</subject><subject>Pain - physiopathology</subject><subject>Pain - prevention & control</subject><subject>Pain Measurement - methods</subject><subject>pain, experimental</subject><subject>Physical Stimulation</subject><subject>Piroxicam - analogs & derivatives</subject><subject>Piroxicam - pharmacology</subject><subject>Piroxicam - therapeutic use</subject><subject>Single-Blind Method</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90VFr1TAUB_AiirubvvgBJAiKCHVJmzaJbzI2J1xQUIf4EtL0dMu1Te6SZuw--8U9oxcFkT0FDr-c5Jx_UTxj9C2jqj7uNubYgKeyelCsGBesbIVgD4sVpVSUVLHqoDhMaUMpE5VqHhcHTPKaCs5Xxa91iD7cOmsmYq9MNHaG6NKMhXHckSn0eTQzJGIhQhfNSLbG-XIbg4WUnL8kzpOrPBlPbsKY_QwQ0ztiyJC9nV3weGMylx6wI4mQsOAtEIe1u8tpzv3uSfFoMGOCp_vzqPh2dvr15Lxcf_rw8eT9urRc8bkU9aCaoVOya7iq-kZWDcVBhw5Yx_qWSjCtZbI3UoDqaU0ViBa6tuqlNFzS-qh4tfTF319nSLOeXLIwjsZDyEkLXAlt2xbh63sh46qVqq7rCumLf-gm5IhTo1JCUqG4QPRmQTaGlCIMehtxA3GnGdV3EWqMUC8RIn6-75i7Cfq_dJ8ZgpcLCHl7f6NycRgn3P6RJv7UrahFo8-__9Bs_fmsuvjS6Av0fPGAGdw4iDpZB5hW7yLYWffB_e-Z30SGyC0</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>Lorenz, I.H.</creator><creator>Egger, K.</creator><creator>Schubert, H.</creator><creator>Schnürer, C.</creator><creator>Tiefenthaler, W.</creator><creator>Hohlrieder, M.</creator><creator>Schocke, M.F.</creator><creator>Kremser, C.</creator><creator>Esterhammer, R.</creator><creator>Ischebeck, A.</creator><creator>Moser, P.L.</creator><creator>Kolbitsch, C.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>6I.</scope><scope>AAFTH</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20080601</creationdate><title>Lornoxicam characteristically modulates cerebral pain-processing in human volunteers: a functional magnetic resonance imaging study</title><author>Lorenz, I.H. ; Egger, K. ; Schubert, H. ; Schnürer, C. ; Tiefenthaler, W. ; Hohlrieder, M. ; Schocke, M.F. ; Kremser, C. ; Esterhammer, R. ; Ischebeck, A. ; Moser, P.L. ; Kolbitsch, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-73f95fb98b5492d58250677fbe1b1d608ea6c18da87e9d0309e76eb62d88a4803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>brain</topic><topic>Brain - drug effects</topic><topic>Brain - physiopathology</topic><topic>Brain mapping</topic><topic>Brain Mapping - methods</topic><topic>brain, magnetic resonance imaging</topic><topic>brain, metabolism</topic><topic>brain, oxygen consumption</topic><topic>experimental</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>metabolism</topic><topic>oxygen consumption</topic><topic>pain</topic><topic>Pain - etiology</topic><topic>Pain - physiopathology</topic><topic>Pain - prevention & control</topic><topic>Pain Measurement - methods</topic><topic>pain, experimental</topic><topic>Physical Stimulation</topic><topic>Piroxicam - analogs & derivatives</topic><topic>Piroxicam - pharmacology</topic><topic>Piroxicam - therapeutic use</topic><topic>Single-Blind Method</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lorenz, I.H.</creatorcontrib><creatorcontrib>Egger, K.</creatorcontrib><creatorcontrib>Schubert, H.</creatorcontrib><creatorcontrib>Schnürer, C.</creatorcontrib><creatorcontrib>Tiefenthaler, W.</creatorcontrib><creatorcontrib>Hohlrieder, M.</creatorcontrib><creatorcontrib>Schocke, M.F.</creatorcontrib><creatorcontrib>Kremser, C.</creatorcontrib><creatorcontrib>Esterhammer, R.</creatorcontrib><creatorcontrib>Ischebeck, A.</creatorcontrib><creatorcontrib>Moser, P.L.</creatorcontrib><creatorcontrib>Kolbitsch, C.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lorenz, I.H.</au><au>Egger, K.</au><au>Schubert, H.</au><au>Schnürer, C.</au><au>Tiefenthaler, W.</au><au>Hohlrieder, M.</au><au>Schocke, M.F.</au><au>Kremser, C.</au><au>Esterhammer, R.</au><au>Ischebeck, A.</au><au>Moser, P.L.</au><au>Kolbitsch, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lornoxicam characteristically modulates cerebral pain-processing in human volunteers: a functional magnetic resonance imaging study</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><addtitle>Br J Anaesth</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>100</volume><issue>6</issue><spage>827</spage><epage>833</epage><pages>827-833</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>Lornoxicam like other non-steroidal anti-inflammatory drugs (NSAIDs) is widely used for postoperative pain therapy. Evaluation of the effect of lornoxicam on cerebral processing of surgical pain was thus the aim of the present functional magnetic resonance imaging (fMRI) study.
An fMRI-compatible pain model that mimics surgical pain was used to induce pain rated 4–5 on a visual analogue scale (VAS) at the anterior margin of the right tibia in volunteers (n=22) after i.v. administration of saline (n=11) or lornoxicam (0.1 mg kg−1) (n=11).
Lornoxicam, which significantly reduced pain sensation [VAS: mean (sd) 4.6 (0.7) vs 1.2 (1.5)], completely suppressed pain-induced activation in the SII/operculum, anterior cingulate cortex, insula, parietal (inferior), prefrontal (inferior, medial), temporal (inferior, medial/superior) lobe, cerebellum, and contralateral (e.g. left-sided) postcentral gyrus (SI). Only the hippocampus and the contralateral superior parietal lobe (BA 7) were activated.
As compared with saline, lornoxicam typically suppressed pain-induced brain activation in all regions except the hippocampus. Furthermore, de novo activation was found in the contralateral, superior parietal lobe (BA 7).</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>18430744</pmid><doi>10.1093/bja/aen082</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0007-0912 |
ispartof | British journal of anaesthesia : BJA, 2008-06, Vol.100 (6), p.827-833 |
issn | 0007-0912 1471-6771 |
language | eng |
recordid | cdi_proquest_miscellaneous_70740666 |
source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
subjects | Adult Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use brain Brain - drug effects Brain - physiopathology Brain mapping Brain Mapping - methods brain, magnetic resonance imaging brain, metabolism brain, oxygen consumption experimental Humans Magnetic Resonance Imaging Male metabolism oxygen consumption pain Pain - etiology Pain - physiopathology Pain - prevention & control Pain Measurement - methods pain, experimental Physical Stimulation Piroxicam - analogs & derivatives Piroxicam - pharmacology Piroxicam - therapeutic use Single-Blind Method |
title | Lornoxicam characteristically modulates cerebral pain-processing in human volunteers: a functional magnetic resonance imaging study |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T01%3A02%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lornoxicam%20characteristically%20modulates%20cerebral%20pain-processing%20in%20human%20volunteers:%20a%20functional%20magnetic%20resonance%20imaging%20study&rft.jtitle=British%20journal%20of%20anaesthesia%20:%20BJA&rft.au=Lorenz,%20I.H.&rft.date=2008-06-01&rft.volume=100&rft.issue=6&rft.spage=827&rft.epage=833&rft.pages=827-833&rft.issn=0007-0912&rft.eissn=1471-6771&rft.coden=BJANAD&rft_id=info:doi/10.1093/bja/aen082&rft_dat=%3Cproquest_cross%3E1499794081%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=197807947&rft_id=info:pmid/18430744&rft_oup_id=10.1093/bja/aen082&rft_els_id=S0007091217343039&rfr_iscdi=true |