Prognostic value of lymphovascular invasion in women with lymph node negative invasive breast carcinoma
This study aimed to test the hypothesis that lymphovascular invasion adds prognostic information to histological grade and tumour size in node-negative invasive carcinoma of the breast. Lymphovascular invasion was assessed in haematoxylin and eosin tumour sections from 2760 patients with node-negati...
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| Veröffentlicht in: | European journal of cancer (1990) 2006-02, Vol.42 (3), p.357-362 |
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| container_title | European journal of cancer (1990) |
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| creator | Lee, A.H.S. Pinder, S.E. Macmillan, R.D. Mitchell, M. Ellis, I.O. Elston, C.W. Blamey, R.W. |
| description | This study aimed to test the hypothesis that lymphovascular invasion adds prognostic information to histological grade and tumour size in node-negative invasive carcinoma of the breast. Lymphovascular invasion was assessed in haematoxylin and eosin tumour sections from 2760 patients with node-negative invasive breast carcinoma treated with definitive surgery. Patients were divided into two groups: 990 in the no adjuvant therapy series (diagnosed in 1974–1988) with median follow-up of 13 years; and 1765 in the selective adjuvant therapy series (1988–2000) with median follow-up of 6.8 years. Lymphovascular invasion was identified in 19% of tumours and was associated with larger tumour size, higher histological grade and younger age. Overall, survival was associated on multivariate analysis with lymphovascular invasion, histological grade and tumour size in both patient series, and with histological type in the no adjuvant therapy series. In conclusion, lymphovascular invasion is an independent prognostic factor in node-negative breast cancer and should be considered in decisions about adjuvant treatment in this group of women. |
| doi_str_mv | 10.1016/j.ejca.2005.10.021 |
| format | Article |
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Lymphovascular invasion was assessed in haematoxylin and eosin tumour sections from 2760 patients with node-negative invasive breast carcinoma treated with definitive surgery. Patients were divided into two groups: 990 in the no adjuvant therapy series (diagnosed in 1974–1988) with median follow-up of 13 years; and 1765 in the selective adjuvant therapy series (1988–2000) with median follow-up of 6.8 years. Lymphovascular invasion was identified in 19% of tumours and was associated with larger tumour size, higher histological grade and younger age. Overall, survival was associated on multivariate analysis with lymphovascular invasion, histological grade and tumour size in both patient series, and with histological type in the no adjuvant therapy series. In conclusion, lymphovascular invasion is an independent prognostic factor in node-negative breast cancer and should be considered in decisions about adjuvant treatment in this group of women.</description><identifier>ISSN: 0959-8049</identifier><identifier>EISSN: 1879-0852</identifier><identifier>DOI: 10.1016/j.ejca.2005.10.021</identifier><identifier>PMID: 16377180</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Breast carcinoma ; Breast Neoplasms - pathology ; Female ; Follow-Up Studies ; Histological grade ; Histological type ; Humans ; Lymph Nodes - pathology ; Lymphatic Metastasis - pathology ; Lymphovascular invasion ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Neoplasm Invasiveness - pathology ; Neoplasm Staging ; Node-negative ; Pharmacology. Drug treatments ; Prognosis ; Tumors</subject><ispartof>European journal of cancer (1990), 2006-02, Vol.42 (3), p.357-362</ispartof><rights>2005 Elsevier Ltd</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-33bd22ada3a32e8fc234b8e6494edfdc1ff0f51012dc7a9ccc563d2fe0cfc4163</citedby><cites>FETCH-LOGICAL-c384t-33bd22ada3a32e8fc234b8e6494edfdc1ff0f51012dc7a9ccc563d2fe0cfc4163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0959804905010038$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17485410$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16377180$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, A.H.S.</creatorcontrib><creatorcontrib>Pinder, S.E.</creatorcontrib><creatorcontrib>Macmillan, R.D.</creatorcontrib><creatorcontrib>Mitchell, M.</creatorcontrib><creatorcontrib>Ellis, I.O.</creatorcontrib><creatorcontrib>Elston, C.W.</creatorcontrib><creatorcontrib>Blamey, R.W.</creatorcontrib><title>Prognostic value of lymphovascular invasion in women with lymph node negative invasive breast carcinoma</title><title>European journal of cancer (1990)</title><addtitle>Eur J Cancer</addtitle><description>This study aimed to test the hypothesis that lymphovascular invasion adds prognostic information to histological grade and tumour size in node-negative invasive carcinoma of the breast. Lymphovascular invasion was assessed in haematoxylin and eosin tumour sections from 2760 patients with node-negative invasive breast carcinoma treated with definitive surgery. Patients were divided into two groups: 990 in the no adjuvant therapy series (diagnosed in 1974–1988) with median follow-up of 13 years; and 1765 in the selective adjuvant therapy series (1988–2000) with median follow-up of 6.8 years. Lymphovascular invasion was identified in 19% of tumours and was associated with larger tumour size, higher histological grade and younger age. Overall, survival was associated on multivariate analysis with lymphovascular invasion, histological grade and tumour size in both patient series, and with histological type in the no adjuvant therapy series. In conclusion, lymphovascular invasion is an independent prognostic factor in node-negative breast cancer and should be considered in decisions about adjuvant treatment in this group of women.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Breast carcinoma</subject><subject>Breast Neoplasms - pathology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Histological grade</subject><subject>Histological type</subject><subject>Humans</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Lymphovascular invasion</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Neoplasm Staging</subject><subject>Node-negative</subject><subject>Pharmacology. Drug treatments</subject><subject>Prognosis</subject><subject>Tumors</subject><issn>0959-8049</issn><issn>1879-0852</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0EotvCH-CAcoFblvFHNonEBVVAkSrBAc6WdzzeepXYi51s1X-Po43UGxf71eiZ0czD2DsOWw589-m4pSOarQBoSmELgr9gG961fQ1dI16yDfRNX3eg-it2nfMRANpOwWt2xXeybXkHG3b4leIhxDx5rM5mmKmKrhqextNDPJuM82BS5UOJPoYSqsc4Unn99HChqhAtVYEOZvJnWtES9olMnio0CX2Io3nDXjkzZHq7_jfsz7evv2_v6vuf33_cfrmvUXZqqqXcWyGMNdJIQZ1DIdW-o53qFVlnkTsHrinXC4ut6RGx2UkrHAE6VOWsG_bxMveU4t-Z8qRHn5GGwQSKc9YttAqkgAKKC4gp5pzI6VPyo0lPmoNe9OqjXvTqRe9SK3pL0_t1-rwfyT63rD4L8GEFijwzuGQC-vzMtaprFF-4zxeOiouzp6QzegpI1ifCSdvo_7fHP5B5m4M</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>Lee, A.H.S.</creator><creator>Pinder, S.E.</creator><creator>Macmillan, R.D.</creator><creator>Mitchell, M.</creator><creator>Ellis, I.O.</creator><creator>Elston, C.W.</creator><creator>Blamey, R.W.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060201</creationdate><title>Prognostic value of lymphovascular invasion in women with lymph node negative invasive breast carcinoma</title><author>Lee, A.H.S. ; Pinder, S.E. ; Macmillan, R.D. ; Mitchell, M. ; Ellis, I.O. ; Elston, C.W. ; Blamey, R.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-33bd22ada3a32e8fc234b8e6494edfdc1ff0f51012dc7a9ccc563d2fe0cfc4163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Breast carcinoma</topic><topic>Breast Neoplasms - pathology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Histological grade</topic><topic>Histological type</topic><topic>Humans</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Lymphovascular invasion</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Staging</topic><topic>Node-negative</topic><topic>Pharmacology. Drug treatments</topic><topic>Prognosis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, A.H.S.</creatorcontrib><creatorcontrib>Pinder, S.E.</creatorcontrib><creatorcontrib>Macmillan, R.D.</creatorcontrib><creatorcontrib>Mitchell, M.</creatorcontrib><creatorcontrib>Ellis, I.O.</creatorcontrib><creatorcontrib>Elston, C.W.</creatorcontrib><creatorcontrib>Blamey, R.W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cancer (1990)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, A.H.S.</au><au>Pinder, S.E.</au><au>Macmillan, R.D.</au><au>Mitchell, M.</au><au>Ellis, I.O.</au><au>Elston, C.W.</au><au>Blamey, R.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value of lymphovascular invasion in women with lymph node negative invasive breast carcinoma</atitle><jtitle>European journal of cancer (1990)</jtitle><addtitle>Eur J Cancer</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>42</volume><issue>3</issue><spage>357</spage><epage>362</epage><pages>357-362</pages><issn>0959-8049</issn><eissn>1879-0852</eissn><abstract>This study aimed to test the hypothesis that lymphovascular invasion adds prognostic information to histological grade and tumour size in node-negative invasive carcinoma of the breast. Lymphovascular invasion was assessed in haematoxylin and eosin tumour sections from 2760 patients with node-negative invasive breast carcinoma treated with definitive surgery. Patients were divided into two groups: 990 in the no adjuvant therapy series (diagnosed in 1974–1988) with median follow-up of 13 years; and 1765 in the selective adjuvant therapy series (1988–2000) with median follow-up of 6.8 years. Lymphovascular invasion was identified in 19% of tumours and was associated with larger tumour size, higher histological grade and younger age. Overall, survival was associated on multivariate analysis with lymphovascular invasion, histological grade and tumour size in both patient series, and with histological type in the no adjuvant therapy series. In conclusion, lymphovascular invasion is an independent prognostic factor in node-negative breast cancer and should be considered in decisions about adjuvant treatment in this group of women.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16377180</pmid><doi>10.1016/j.ejca.2005.10.021</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Breast carcinoma Breast Neoplasms - pathology Female Follow-Up Studies Histological grade Histological type Humans Lymph Nodes - pathology Lymphatic Metastasis - pathology Lymphovascular invasion Medical sciences Middle Aged Multivariate Analysis Neoplasm Invasiveness - pathology Neoplasm Staging Node-negative Pharmacology. Drug treatments Prognosis Tumors |
| title | Prognostic value of lymphovascular invasion in women with lymph node negative invasive breast carcinoma |
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