Prostate cancer and Hedgehog signalling pathway

The Hedgehog (Hh) family of intercellular signalling proteins have come to be recognised as key mediators in many fundamental processes in embryonic development. Their activities are central to the growth, patterning and morphogenesis of many different regions within the bodies of vertebrates. In so...

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Veröffentlicht in:Clinical & translational oncology 2007-07, Vol.9 (7), p.420-428
Hauptverfasser: Antón Aparicio, L M, García Campelo, R, Cassinello Espinosa, J, Valladares Ayerbes, M, Reboredo López, M, Díaz Prado, S, Aparicio Gallego, G
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container_end_page 428
container_issue 7
container_start_page 420
container_title Clinical & translational oncology
container_volume 9
creator Antón Aparicio, L M
García Campelo, R
Cassinello Espinosa, J
Valladares Ayerbes, M
Reboredo López, M
Díaz Prado, S
Aparicio Gallego, G
description The Hedgehog (Hh) family of intercellular signalling proteins have come to be recognised as key mediators in many fundamental processes in embryonic development. Their activities are central to the growth, patterning and morphogenesis of many different regions within the bodies of vertebrates. In some contexts, Hh signals act as morphogens in the dose-dependent induction of distinct cell fates within a target field, in others as mitogens in the regulation of cell proliferation or as inducing factors controlling the form of a developing organ. These diverse functions of Hh proteins raise many intriguing questions about their mode of action. Various studies have now demonstrated the function of Hh signalling in the control of cell proliferation, especially for stem cells and stem-like progenitors. Abnormal activation of the Hh pathway has been demonstrated in a variety of human tumours. Hh pathway activity in these tumours is required for cancer cell proliferation and tumour growth. Recent studies have uncovered the role for Hh signalling in advanced prostate cancer and demonstrated that autocrine signalling by tumour cells is required for proliferation, viability and invasive behaviour. Thus, Hh signalling represents a novel pathway in prostate cancer that offers opportunities for prognostic biomarker development, drug targeting and therapeutic response monitoring.
doi_str_mv 10.1007/s12094-007-0080-x
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subjects Animals
Epithelial Cells - metabolism
Hedgehog Proteins - genetics
Hedgehog Proteins - metabolism
Humans
Male
Mesoderm - metabolism
Models, Biological
Prostate - metabolism
Prostatic Neoplasms - metabolism
Signal Transduction
title Prostate cancer and Hedgehog signalling pathway
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